Earth-to-air heat exchangers (EAHEs) can be used in the ventilation systems of various types of buildings. Multipipe structures can be found in large-volume buildings, yet scientific analysis of such systems is rare. Annual energy gains and electricity consumption for equivalent single-pipe and multipipe systems are typically not available. This paper bridges this gap, presenting the results of experimental studies on pressure losses in three-, five- and seven-pipe EAHEs and analysis for the annual energy gains and electric energy consumption as compared to a single-pipe exchanger. The results showed that the multipipe EAHE can be successfully replaced by a single-pipe structure with the same thermal performance and similar pressure losses if a tube with the appropriate diameter is used. However, multipipe heat exchangers can also use pipes of larger diameter (manifolds and/or branches), which improves their energy efficiency and may then make them more advantageous than single-pipe structures. From this reason, ultimately, the final selection of exchanger geometry should take into account economic and environmental issues and also user preferences and their importance in the hierarchy.