The use of a lateral patellar autologous graft for the repair of a large osteochondral defect in the knee.

Outerbridge, H. K.; Outerbridge, A R; Outerbridge, R. E.

doi:10.2106/00004623-199501000-00009

Cited by 244 publications

(120 citation statements)

References 18 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…Many methods of treatment have been used to decrease pain and improve the level of M function of affected individuals. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] These procedures, however, have numerous shortcomings such as the formation of fibrocartilaginous repair tissue, which lacks the mechanical properties of normal articular cartilage, limited tissue availability, donor-site morbidity with autografts, the possibility of transmission of disease, and handling difficulties with allografts. Consequently, recent research has focused on laboratory-engineered osteochondral tissue.…”

mentioning

confidence: 99%

Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads

Dragoo¹,

Samimi

Zhu

et al. 2003

The Journal of Bone and Joint Surgery. British volume

267

198

View full text Add to dashboard Cite

ultipotential processed lipoaspirate (PLA) cells extracted from five human infrapatellar fat pads and embedded into fibrin glue nodules, were induced into the chondrogenic phenotype using chondrogenic media. The remaining cells were placed in osteogenic media and were transfected with an adenovirus carrying the cDNA for bone morphogenetic protein-2 (BMP-2). We evaluated the tissue-engineered cartilage and bone using in vitro techniques and by placing cells into the hind legs of five severe combined immunodeficient mice.After six weeks, radiological and histological analysis indicated that the PLA cells induced into the chondrogenic phenotype had the histological appearance of hyaline cartilage. Cells transfected with the BMP-2 gene media produced abundant bone, which was beginning to establish a marrow cavity. Tissueengineered cartilage and bone from infrapatellar fat pads may prove to be useful for the treatment of osteochondral defects. [Br] 2003;85-B:740-7. J Bone Joint Surg

show abstract

mentioning

confidence: 99%

Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads

Dragoo¹,

Samimi

Zhu

et al. 2003

The Journal of Bone and Joint Surgery. British volume

267

198

View full text Add to dashboard Cite

show abstract

“…A lot of basic research in articular cartilage repair has been conducted [16,21,22] . The purpose of this study was to evaluate and compare three options when restoring osteochondral defects with OATS (mosaicplasty) in a rabbit model.…”

Section: Discussionmentioning

confidence: 99%

Donor’s site evaluation after restoration with autografts or synthetic plugs in rabbits

Intzoglou

Mastrokalos

Korres

et al. 2014

WJO

View full text Add to dashboard Cite

AIM:To investigate donor site's area histological and immunohistochemical knee cartilage appearances after resurfacing iatrogenic defects with biosynthetic plugs orautografts. METHODS:Thirty New Zealand White rabbits were used in this study. A full-thickness cylindrical defect of 4.5 mm (diameter) × 7 mm (depth) was created with a hand drill in the femoral groove of every animal. In Group A (n = 10) the defect of the donor site was repaired with a biosynthetic osteochondral plug, in Group B (n = 10) with an osteochondral autograft, while in Group C (control group of 10) rabbits were left untreated. RESULTS:Twenty-four weeks postoperatively, smooth articular cartilage was found macroscopically in some trocleas' surfaces; in all others, an articular surface with discontinuities was observed. Twenty-eight out of 30 animals were found with predominantly viable chondrocytes leaving the remaining two -which were found only in the control group-with partially viable chondrocytes. However, histology revealed many statistical differences between the groups as far as the International Cartilage Repair Society (ICRS) categories are concerned. Immunofluoresence also revealed the presence of collagen Ⅱ in all specimens of Group B, whereas in Group A collagen Ⅱ was found in less specimens. In Group C collagen Ⅱwas not found. CONCLUSION:The matrix, cell distribution, subchondral bone and cartilage mineralization ICRS categories showed statistically differences between the three groups. Group A was second, while group B received the best scores; the control group got the worst ICRS scores in these categories. So, the donor site area, when repairing osteochondral lesions with autografting systems, is better amended with osteochondral autograft rather than bone graft substitute implant.

show abstract

“…Outerbridge [Outerbridge 1995] demonstrated an improvement in knee function and symptoms at an average of 6.5 years following osteochondral grafts for defects of the femoral condyle. The procedure does not seem to disturb the main nutritional pattern of articular cartilage.…”

Section: Arthroscopic Osteochondral Autograft Transplantation System mentioning

confidence: 99%

Surgery for Osteoarthritis of the Knee

Lewis¹,

Smith²

2012

Osteoarthritis - Diagnosis, Treatment and Surgery

View full text Add to dashboard Cite

The use of a lateral patellar autologous graft for the repair of a large osteochondral defect in the knee.

Cited by 244 publications

References 18 publications

Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads

Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads

Donor’s site evaluation after restoration with autografts or synthetic plugs in rabbits

Surgery for Osteoarthritis of the Knee

Contact Info

Product

Resources

About