The use of a muscle graft to repair a segmentary nerve defect

Oliveira, E.F.; Mazzer, Nílton; Barbieri, Cláudio Henrique; Del‐Bel, Elaine

doi:10.1016/j.jneumeth.2003.09.010

Cited by 24 publications

(3 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the parameters of axons, axon diameter and thickness of myelin sheath were greater in the PANI/RC group compared with the corresponding parameters in the RC group and lower than those noted in the sham group. The histological data were similar with the findings reported in previous studies ( 17 – 19 ).…”

Section: Discussionsupporting

confidence: 91%

Polyaniline promotes peripheral nerve regeneration by enhancement of the brain-derived neurotrophic factor and ciliary neurotrophic factor expression and activation of the ERK1/2/MAPK signaling pathway

Fan

Xiong

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

A previous study has demonstrated a progression in the nerve regeneration by polyaniline/cellulose (PANI/RC), although the underlying mechanism was not elucidated. In the present study, regenerated nerves were investigated, using histological techniques, functional assays and western blot analysis. The triceps surae muscle weight ratio percentages of the sham, regenerated cellulose (RC) and the PANI/RC groups were 38.88±4.76 and 76.32±7.11%, respectively. The thickness of the myelin sheath for the aforementioned groups were as follows: 1.2±0.27; 0.49±0.21 and 0.93±0.28 µl. Western blot analysis demonstrated that the ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) were highly expressed in the regenerated nerve in the presence of polyaniline. Phosphorylated extracellular kinase (p-ERK)1/2 expression in the PANI/RC group was significantly elevated compared with the RC group (1.83-fold) and the sham group (4.92-fold). The expression of the axon sprout-associated proteins, such as Tau, α-tubulin and growth associated protein-43, were increased (1.64, 1.59 and 1.24-fold, respectively) compared with the RC group. The results demonstrated that PANI enhances the expression and secretion of BDNF and CNTF, activates the ERK1/2 signaling pathway and increases the expression levels of the GAP-43, Tau and α-tubulin, suggesting an insight into nerve regeneration and possible clinical interventions in nerve injury.

show abstract

Section: Discussionsupporting

confidence: 91%

Polyaniline promotes peripheral nerve regeneration by enhancement of the brain-derived neurotrophic factor and ciliary neurotrophic factor expression and activation of the ERK1/2/MAPK signaling pathway

Fan

Xiong

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

“…It has been reported that administration of NGF resulted in an increase in average number of myelinated axons and improved EMG signals . In addition to NGF, previous studies have found that systemic administration of IGF‐1 promoted neuronal survival following crush injury and improved muscle reinnervation . Locally delivered IGF‐1 following crush injury can improve sensory function and improve muscle function in rats .…”

Section: Discussionmentioning

confidence: 99%

Ketogenic Diet Potentiates Electrical Stimulation–Induced Peripheral Nerve Regeneration after Sciatic Nerve Crush Injury in Rats

Liu

et al. 2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope: Recent findings indicate that the ketogenic diet (KD) is neuroprotective and electrical stimulation (ES) can improve functional recovery from peripheral nerve injury. However, it is not clear whether KD and ES play a synergistical role in the peripheral nerve recovery following injury. Methods and results: A KD consisting of a 3:1 ratio of fat to carbohydrate + protein is used and is coupled with ES treatment in a rat model of peripheral nerve crush injury. Neuromuscular recovery is evaluated by electromyography, and axonal regeneration and myelination by histological methods. The effects on insulin-like growth factor 1 (IGF-1) and IGF-1 receptor expression in peripheral nerve tissue, pre-and post-nerve injury, are also investigated. The combination of KD and ES synergistically increases muscle force in biceps femoris and gluteus maximus and prevents development of hypersensitivity in biceps femoris. It promotes peripheral nerve regeneration by increasing total axons, axon density, and axonal diameter, as well as myelin thickness and axon/fiber ratio. These effects are due to modulation of the IGF system as the treatment expression of IGF-1 and IGF-1 receptor in regenerated nerve tissue. Conclusion: The results establish that KD and ES promote peripheral nerve regeneration. Patients recovering from peripheral nerve injury may benefit from this combinational approach.

show abstract

“… 33 Along with these results, it has been suggested that bridging is the best type of peripheral nerve repair. 34 But what is the molecular mechanism behind this bridging? Another explanation for the effect of ES in our study could be that gene expression of nerve growth factors is increased.…”

Section: Discussionmentioning

confidence: 99%

Effect of electrical stimulation on motor nerve regeneration in sciatic nerve ligated-mice

Samiee¹,

Zarrindast²

2017

Eur J Transl Myol

View full text Add to dashboard Cite

The purpose of this study was to investigate the effect of electrical stimulation on sciatic nerve regeneration and functional recovery of target muscles. Mice were randomly divided into 3 groups: ligated without electrical stimulation, ligated with electrical stimulation and control (non-ligated). The unilateral peripheral mononeuropathy was produced on the right hind limb. Sciatic nerve was then electrically stimulated daily for a period of 2 weeks (duration: 0.2 msec, frequency: 100Hz, amplitude: 15mA). Evoked surface EMG was recorded from biceps femoris (BF) and gluteus maximus (GM) muscles on the 3rd, 7th, 10th and 14th day after sciatic nerve ligation. Muscle force and sensitivity was determined by processing of the recorded EMG signals in time and frequency domains respectively. The results showed electrical stimulation (ES) produced a significant increase in the EMG response of BF, and muscle force significantly increased on the 14th day (p<0.001), however no significant difference was found in GM muscle force between experimental groups. This may be due to possible innervation by inferior gluteal nerve. Frequency analysis of BF signals indicates that hyperalgesia remained after 14 days in both ligated groups. On the 14th day no difference in GM muscle sensitivity was found between groups. In conclusion, the results of this study have shown that the electrical stimulation of sciatic nerve accelerates nerve repair and indirectly improves BF muscle force to a comparable level with control without effect on muscle sensitivity. However, ES had no effect on GM muscle force and sensitivity.

show abstract

The use of a muscle graft to repair a segmentary nerve defect

Cited by 24 publications

References 45 publications

Polyaniline promotes peripheral nerve regeneration by enhancement of the brain-derived neurotrophic factor and ciliary neurotrophic factor expression and activation of the ERK1/2/MAPK signaling pathway

Polyaniline promotes peripheral nerve regeneration by enhancement of the brain-derived neurotrophic factor and ciliary neurotrophic factor expression and activation of the ERK1/2/MAPK signaling pathway

Ketogenic Diet Potentiates Electrical Stimulation–Induced Peripheral Nerve Regeneration after Sciatic Nerve Crush Injury in Rats

Effect of electrical stimulation on motor nerve regeneration in sciatic nerve ligated-mice

Contact Info

Product

Resources

About