The Use of a Novel Reverse Thermosensitive Polymer to Prevent Ureteral Stone Retropulsion During Intracorporeal Lithotripsy: A Randomized, Controlled Trial

Rané, Abhay; Bradoo, Anil; Rao, Pradeep; Shivde, Subodh R.; Elhilali, Mostafa; Anidjar, Maurice; Pace, Kenneth T.; Honey, John

doi:10.1016/j.juro.2009.12.023

Cited by 55 publications

(32 citation statements)

References 14 publications

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“…The first, a RCT, looked at URS with and without a backstop device [60]. SFRs were high in both groups (93.9% with backstop device compared to 87.8% without, p-value = 0.7).…”

Section: Urs With and Without Methods For Preventing Retrograde Stonementioning

confidence: 99%

What are the Benefits and Harms of Ureteroscopy Compared with Shock-wave Lithotripsy in the Treatment of Upper Ureteral Stones? A Systematic Review

et al. 2017

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“…The first, a RCT, looked at URS with and without a backstop device [60]. SFRs were high in both groups (93.9% with backstop device compared to 87.8% without, p-value = 0.7).…”

Section: Urs With and Without Methods For Preventing Retrograde Stonementioning

confidence: 99%

What are the Benefits and Harms of Ureteroscopy Compared with Shock-wave Lithotripsy in the Treatment of Upper Ureteral Stones? A Systematic Review

et al. 2017

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“…It is currently used clinically to decrease stone retropulsion during ureteroscopic stone fragmentation and was approved for this indication by the Food and Drug Administration in 2009. 8 RTP's ability to completely occlude the ureter and prevent stone migration appears to translate well to increase MMC dwell time. We chose to investigate an ureteroscopic model, because this is the least invasive method of endoscopic treatment of UUC.…”

Section: Discussionmentioning

confidence: 99%

“…RTP is viscous at body temperature and a liquid below 16°C, so injection of room temperature saline through the ureteral catheter changed it to liquid. 8 Data were analyzed with JMP version 9.0, SASÒ Inc (Cary, NC).…”

Section: Methodsmentioning

confidence: 99%

Third Place: Increasing Dwell Time of Mitomycin C in the Upper Tract with a Reverse Thermosensitive Polymer

Wang

Goldsmith²,

Neisius³

et al. 2013

Journal of Endourology

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Background and Purpose: Topical chemotherapy for urothelial cancer is dependent on adequate contact time of the chemotherapeutic agent with the urothelium. To date, there has not been a reliable method of maintaining this contact for renal or ureteral urothelial carcinoma. We evaluated the safety and feasibility of using a reverse thermosensitive polymer to improve dwell times of mitomycin C (MMC) in the upper tract. Materials and Methods: Using a porcine model, four animals were treated ureteroscopically with both upper urinary tracts receiving MMC mixed with iodinated contrast. One additional animal received MMC percutaneously. The treatment side had ureteral outflow blocked with a reverse thermosensitive polymer plug. MMC dwell time was monitored fluoroscopically and intrarenal pressures measured. Two animals were euthanized immediately, and three animals were euthanized 5 days afterward. Results: In control kidneys, drainage occurred at a mean of 5.3 -0.58 minutes. Intrarenal pressures stayed fairly stable: 9.7 -14.0 cm H 2 0. In treatment kidneys, dwell time was extended to 60 minutes, when the polymer was washed out. Intrarenal pressures in the treatment kidneys peaked at 75.0 -14.7 cm H 2 0 and reached steady state at 60 cm H 2 0. Pressures normalized after washout of the polymer with cool saline. Average washout time was 11.8 -9.6 minutes. No histopathologic differences were seen between the control and treatment kidneys, or with immediate compared with delayed euthanasia. Conclusions: A reverse thermosensitive polymer can retain MMC in the upper urinary tract and appears to be safe from our examination of intrarenal pressures and histopathology. This technique may improve the efficacy of topical chemotherapy in the management of upper tract urothelial carcinoma.

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“…Rane and colleagues reported the use of a thermosensitive polymer, Backstop, to prevent stone retropulsion [Rane et al 2010]. The polymer is Therapeutic Advances in Urology 3 (3) deployed proximal to the stone to occlude the ureter.…”

Section: Muesmentioning

confidence: 99%

Instrumentation in endourology

Khanna

Monga²

2011

Therapeutic Advances in Urology

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The Use of a Novel Reverse Thermosensitive Polymer to Prevent Ureteral Stone Retropulsion During Intracorporeal Lithotripsy: A Randomized, Controlled Trial

Abstract: BackStop appears to be a novel, safe and effective means of preventing stone fragment retropulsion during ureteroscopic lithotripsy for the management of ureteral stones.

Cited by 55 publications

References 14 publications

What are the Benefits and Harms of Ureteroscopy Compared with Shock-wave Lithotripsy in the Treatment of Upper Ureteral Stones? A Systematic Review

What are the Benefits and Harms of Ureteroscopy Compared with Shock-wave Lithotripsy in the Treatment of Upper Ureteral Stones? A Systematic Review

Third Place: Increasing Dwell Time of Mitomycin C in the Upper Tract with a Reverse Thermosensitive Polymer

Instrumentation in endourology

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