The use of a radial basis neural network and genetic algorithm for improving the efficiency of laccase-mediated dye decolourization

Schubert, Mark; Muffler, A.; Mourad, Safer

doi:10.1016/j.jbiotec.2012.08.003

Cited by 19 publications

(14 citation statements)

References 40 publications

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“…It is likely that yields can be further increased by optimizing laccase and mediator concentrations, e.g. with a neural network approach [32]. Fed-batch type biotransformations with continuous addition of phenolic educts, iodide and laccase may also facilitate even higher volumetric yields.…”

Section: Discussionmentioning

confidence: 99%

Laccase Catalyzed Synthesis of Iodinated Phenolic Compounds with Antifungal Activity

et al. 2014

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Iodine is a well known antimicrobial compound. Laccase, an oxidoreductase which couples the one electron oxidation of diverse phenolic and non-phenolic substrates to the reduction of oxygen to water, is capable of oxidizing unreactive iodide to reactive iodine. We have shown previously that laccase-iodide treatment of spruce wood results in a wash-out resistant antimicrobial surface. In this study, we investigated whether phenolic compounds such as vanillin, which resembles sub-structures of softwood lignin, can be directly iodinated by reacting with laccase and iodide, resulting in compounds with antifungal activity. HPLC-MS analysis showed that vanillin was converted to iodovanillin by laccase catalysis at an excess of potassium iodide. No conversion of vanillin occurred in the absence of enzyme. The addition of redox mediators in catalytic concentrations increased the rate of iodide oxidation ten-fold and the yield of iodovanillin by 50%. Iodinated phenolic products were also detected when o-vanillin, ethyl vanillin, acetovanillone and methyl vanillate were incubated with laccase and iodide. At an increased educt concentration of 0.1 M an almost one to one molar ratio of iodide to vanillin could be used without compromising conversion rate, and the insoluble iodovanillin product could be recovered by simple centrifugation. The novel enzymatic synthesis procedure fulfills key criteria of green chemistry. Biocatalytically produced iodovanillin and iodo-ethyl vanillin had significant growth inhibitory effects on several wood degrading fungal species. For Trametes versicolor, a species causing white rot of wood, almost complete growth inhibition and a partial biocidal effect was observed on agar plates. Enzymatic tests indicated that the iodinated compounds acted as enzyme responsive, antimicrobial materials.

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Section: Discussionmentioning

confidence: 99%

Laccase Catalyzed Synthesis of Iodinated Phenolic Compounds with Antifungal Activity

et al. 2014

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“…Hybrid models employ a combination of ANNs and GAs (Franco-Lara et al, 2006;Yuan et al, 2014). A hybrid ANN model optimized by GA (Gupta et al, 2012) was constructed and applied in some areas of wastewater treatment (Badrnezhad and Mirza, 2013;Schubert et al, 2012;SUDARSANA RAO and SUBBA REDDY, 2012). GA was used to optimize the weights M a n u s c r i p t 10 and thresholds of ANN for minimizing the error between the actual and target outputs.…”

Section: Page 6 Of 47mentioning

confidence: 99%

Modeling and optimization of activated sludge bulking for a real wastewater treatment plant using hybrid artificial neural networks-genetic algorithm approach

Bagheri

Mirbagheri

Bagheri

et al. 2015

Process Safety and Environmental Protection

126

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“…The calculated models can only be used within the chosen range of experimental conditions, but not for extrapolation which is a drawback for both methodologies. Nevertheless, the results of this study demonstrate that modeling approaches, particularly the ANN neural network, combined with genetic algorithm, represent a significant advance for the analysis and optimization of biocatalytical processes (Schubert et al, 2012b;Witek-Krowiak et al, 2014).…”

Section: Resultsmentioning

confidence: 92%

Prediction and optimization of the laccase-mediated synthesis of the antimicrobial compound iodine (I2)

Schubert

Fey

Ihssen

et al. 2015

Journal of Biotechnology

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The use of a radial basis neural network and genetic algorithm for improving the efficiency of laccase-mediated dye decolourization

Cited by 19 publications

References 40 publications

Laccase Catalyzed Synthesis of Iodinated Phenolic Compounds with Antifungal Activity

Laccase Catalyzed Synthesis of Iodinated Phenolic Compounds with Antifungal Activity

Modeling and optimization of activated sludge bulking for a real wastewater treatment plant using hybrid artificial neural networks-genetic algorithm approach

Prediction and optimization of the laccase-mediated synthesis of the antimicrobial compound iodine (I2)

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