The Use of a Thermally Reversible Bond for Molecular Imprinting of Silica Spheres

Abstract

A silica monomer-estrone complex (EstSi) having a thermally cleavable urethane bond and a cross-linkable triethoxysilane group was synthesized. From EstSi and TEOS, spherical silica particles with sizes of 1.5-3 mum were prepared. The template molecules were removed from the silica matrix by heating at 180 degrees C in DMSO in the presence of water, generating a cavity with an amino group. The control silica particles that had the same sizes and shapes were obtained with aminopropyl triethoxysilane and TEOS. When ethylene glycol was added in place of H2O, an ethyl alcoholic group was formed in the cavity. Their recognition ability and specific binding for estrone were characterized by uptake experiments. The estrone-imprinted silica particles showed a much higher recognition ability than the control silica particles and higher selectivity for estrone than testosterone propionate.

Novel Hg2+-imprinted polymers based on thymine–Hg2+–thymine interaction for highly selective preconcentration of Hg2+ in water samples

“…T-IPTS was synthesized through the coupling reaction between the isocyanato group of IPTS and the hydroxyl moiety of T-OH, forming a urethane bond. This method was similar to the semi-covalent imprinting technique reported in references [31,33,34]. The formation of the urethane bonds had been confirmed by the MS, 1 H NMR and 13 C NMR measurements.…”

“…Then the residue was crystallized from dichloromethane to give T-OH as white solid. Characterization data of T-OH were as follows: 1 And then T-IPTS was synthesized by virtue of semi-covalent imprinting technique [31]. Briefly, T-OH (0.85 g, 5 mmol) was dissolved in 50 mL of dried THF.…”

A synthetic nanomaterial for virus recognition produced by surface imprinting

“…It is based on the formation of a supramolecular complex of organic monomers together with a template molecule before polymerization. This procedure enables the threedimensional positioning of the recognition units in the produced organic polymer 15,16 . Inorganic molecularly imprinted materials have also been developed.…”

Molecularly imprinted TiO2hybridized magnetic Fe3O4nanoparticles for selective photocatalytic degradation and removal of estrone

“…In this work, LPD method involved in aqueous solution was employed for estrone imprinting, and the obtained MIPs were used to remove organic pollutants in aqueous environment. In order to achieve ideal molecular imprinting in aqueous environment, semi-covalent approach 23 Fig. 1), which resulted in low binding capacity and mass transfer rate.…”