“…47 Studies included a variety of interventions. Thirteen studies included surgical interventions, 22,25,26,30,32,34,36,37,39,42,44,46,48 9 studies included primarily medical interventions, 21,24,27,31,40,41,43,45,47 1 study included both medical and surgical interventions, 23 and 6 were observational. 28,29,33,35,38,49 Among the randomized interventions, 4 were placebo controlled.…”