The use of additional imaging increased specificity and decreased sensitivity in screening mammography

Geller, Berta M.; Vacek, Pamela M.; Skelly, Joan M.; Harvey, Susan C.

doi:10.1016/j.jclinepi.2005.02.009

Cited by 11 publications

(6 citation statements)

References 45 publications

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“…and the details on the excluded studies are presented in Additional file 1[32-47]. Six cohort studies conforming to the inclusion criteria are discussed in detail (Additional file 2, Part 1; Additional file 3, Part II).…”

Section: Resultsmentioning

confidence: 99%

Early detection of breast cancer: benefits and risks of supplemental breast ultrasound in asymptomatic women with mammographically dense breast tissue. A systematic review

et al. 2009

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BackgroundMammographic screening alone will miss a certain fraction of malignancies, as evidenced by retrospective reviews of mammograms following a subsequent screening. Mammographic breast density is a marker for increased breast cancer risk and is associated with a higher risk of interval breast cancer, i.e. cancer detected between screening tests. The purpose of this review is to estimate risks and benefits of supplemental breast ultrasound in women with negative mammographic screening with dense breast tissue.MethodsA systematic search and review of studies involving mammography and breast ultrasound for screening of breast cancer was conducted. The search was performed for the period 1/2000-8/2008 within the data source of PubMed, DARE, and Cochrane databases. Inclusion and exclusion criteria were determined prospectively, and the Oxford evidence classification system for diagnostic studies was used for evidence level. The parameters biopsy rate, positive predictive value (PPV) for biopsy, cancer yield for breast ultrasound alone, and carcinoma detection rate by breast density were extracted or constructed.ResultsThe systematic search identified no randomized controlled trials or systematic reviews, six cohort studies of intermediate level of evidence (3b) were found. Only two of the studies included adequate follow-up of subjects with negative or benign findings. Supplemental breast ultrasound after negative mammographic screening permitted diagnosis of primarily invasive carcinomas in 0.32% of women in breast density type categories 2-4 of the American College of Radiology (ACR); mean tumor size for those identified was 9.9 mm, 90% with negative lymph node status. Most detected cancers occurred in mammographically dense breast ACR types 3 and 4. Biopsy rates were in the range 2.3%-4.7%, with PPV of 8.4-13.7% for those biopsied due to positive ultrasound, or about one third of the PPV of biopsies due to mammography. Limitations: The study populations included wide age ranges, and the application to women age 50-69 years as proposed for mammographic screening could result in less striking benefit. Further validation studies should employ a uniform assessment system such as BI-RADS and report not only PPV, but also negative predictive value, sensitivity and specificity.ConclusionSupplemental breast ultrasound in the population of women with mammographically dense breast tissue (ACR 3 and 4) permits detection of small, otherwise occult, breast cancers. Potential adverse impacts for women in this intermediate risk group are associated with an increased biopsy rate.

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Section: Resultsmentioning

confidence: 99%

Early detection of breast cancer: benefits and risks of supplemental breast ultrasound in asymptomatic women with mammographically dense breast tissue. A systematic review

et al. 2009

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“…The analytic dataset included the radiologist's initial interpretation based on two mammographic views and the final interpretation after completion of additional breast imaging within 6 months. Tumors are most commonly missed at the initial interpretation, and scarring after a biopsy could affect the likelihood of the radiologist recommending additional imaging (recall) (20). Therefore, the initial interpretation was used to calculate sensitivity, specificity, PPV1, and overall accuracy (AUC).…”

Section: Measurementsmentioning

confidence: 99%

Effect of Previous Benign Breast Biopsy on the Interpretive Performance of Subsequent Screening Mammography

Taplin

Abraham

Geller

et al. 2010

JNCI: Journal of the National Cancer Institute

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“…Analysis of 2D US data indicated that there was a strong correlation between malignant tumor growth and two specific 2D criteria: lesion margin and effect of the lesion on adjacent breast tissue Einleitung Zur besseren Detektion von Mammabefunden stehen neben Inspektion und Palpation mehrere diagnostische Standardverfahren zur Verfügung. Laut Literatur zeigt die Mammographie dabei in der heutigen Form eine Sensitivität von 78 -92 % und eine Spezifität von 75 -99 % [1 -3], wobei die Sensitivität durch den Einfluss der Gewebedichte, diffuser Tumorausbreitung und des Alters signifikant bis auf 48 % herabgesetzt werden kann [2,4,5]. Bei dem gleichzeitigen Einsatz der Mammasonographie (US) erzielt man einen Anstieg der Sensitivität von bis zu 97 % [2,6].…”

Section: Zusammenfassungunclassified

Dignitätsbeurteilung mammasonographischer Herde mittels dreidimensionaler Darstellung

Fischer

Filimonow²,

Hamm³

et al. 2006

Fortschr Röntgenstr

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The use of additional imaging increased specificity and decreased sensitivity in screening mammography

Cited by 11 publications

References 45 publications

Early detection of breast cancer: benefits and risks of supplemental breast ultrasound in asymptomatic women with mammographically dense breast tissue. A systematic review

Early detection of breast cancer: benefits and risks of supplemental breast ultrasound in asymptomatic women with mammographically dense breast tissue. A systematic review

Effect of Previous Benign Breast Biopsy on the Interpretive Performance of Subsequent Screening Mammography

Dignitätsbeurteilung mammasonographischer Herde mittels dreidimensionaler Darstellung

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