The Use of Alternate-Day Lovastatin in Hypercholesterolemic Men

Dennis, Vincent C.; Britton, Mark L.; Sirmans, Susan M.; Letassy, Nancy A.; Freeman, Dale A.

doi:10.1177/106002809703100607

Cited by 18 publications

(12 citation statements)

References 9 publications

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“…Many previous studies have attempted to use the alternate-day dosing regimen of statin administration in patients with hypercholesterolemia (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Results, however, have been controversial; being discouraging for short-half-life statins: lovastatin, fluvastatin, pravastatin, and simvastatin (12-14, 19, 20).…”

Section: Discussionmentioning

confidence: 99%

Alternate-day versus daily atorvastatin in coronary artery disease: a randomized study

Rifaie¹,

Ahmed²,

Nammas³

2012

Anadolu Kardiyol Derg

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Objective: We sought to compare the effect of alternate-day versus daily atorvastatin 10 mg, on serum low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hs-CRP) in patients with coronary artery disease (CAD) and controlled serum LDL-C by daily atorvastatin. Methods: The study was prospective, randomized, single-blinded, two-armed. Randomization was performed by a computer-generated randomization list. We randomized 60 patients with CAD and controlled serum LDL-C to receive either atorvastatin in the standard-dose of 10 mg daily (Group A=30 patients), or the same medication every other day (Group B=30 patients). Primary efficacy criterion included changes in serum LDL-C and hs-CRP from the initial to the 6-week follow-up values.

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Section: Discussionmentioning

confidence: 99%

Alternate-day versus daily atorvastatin in coronary artery disease: a randomized study

Rifaie¹,

Ahmed²,

Nammas³

2012

Anadolu Kardiyol Derg

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“…Some have tested rapidly metabolized statins, such as lovastatin48,49 fluvastatin,50 or simvastatin 51. However, this approach has been based on the concept that statins with a longer half-life may maintain their lipid lowering effect over a longer period of time.…”

Section: Alternate-day Statin Dosingmentioning

confidence: 99%

Treating statin-intolerant patients

Arca¹,

Pigna²

2011

DMSO

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Statins are effective in reducing cardiovascular events and are safe for almost all patients. Nevertheless, intolerance to statins is frequently faced in clinical practice. This is mostly due to muscular symptoms (myalgia with or without increase of plasma creatinine kinase) and/or elevation of hepatic aminotransferases, which overall constitutes approximately two-thirds of reported adverse events during statin therapy. These side effects raise concerns in patients as well as in doctors and are likely to reduce patients’ adherence and, as a consequence, the cardiovascular benefit. Therefore, it is mandatory that clinicians improve their knowledge on the clinical aspects of muscular and hepatic side effects of statin therapy as well as their ability to manage patients with statin intolerance. Besides briefly examining the clinical aspects and the mechanisms that are proposed to be responsible for the most common statin-associated side effects, the main purpose of this article is to review the available approaches to manage statin-intolerant patients. The first step is to determine whether the adverse events are indeed related to statin therapy. If so, lowering the dosage or changing statin, alternate dosing options, or the use of nonstatin compounds may be practical strategies. The cholesterol-lowering potency as well as the usefulness of these different approaches in treating statin-intolerant patients will be examined based on currently available data. However, the cardiovascular benefit of these strategies has not been well established, so their use has to be guided by a careful clinical assessment of each patient.

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“…Evidence indicates that HMG-CoA reductase inhibitors given every other day are as effective at lowering LDL as daily dosing. [11][12][13] One study evaluated the effects of alternate-day lovastatin dosing on serum lipoprotein levels. 11 Twenty-one patients with an LDL level greater than 160 mg/dl were given lovastatin 20 mg every other day.…”

mentioning

confidence: 99%

Daily Dosing versus Alternate‐Day Dosing of Simvastatin in Patients with Hypercholesterolemia

Copher

Stewart

2002

Pharmacotherapy

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The Use of Alternate-Day Lovastatin in Hypercholesterolemic Men

Abstract: Lovastatin 20 mg every other day may effectively lower LDL-C in some elderly men, and target LDL-C concentrations may be obtained in some patients.

Cited by 18 publications

References 9 publications

Alternate-day versus daily atorvastatin in coronary artery disease: a randomized study

Alternate-day versus daily atorvastatin in coronary artery disease: a randomized study

Treating statin-intolerant patients

Daily Dosing versus Alternate‐Day Dosing of Simvastatin in Patients with Hypercholesterolemia

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