The use of an immunohistochemical diagnostic panel to determine the primary site of cervical lymph node metastases of occult squamous cell carcinoma

Park, Jung Mee; Jung, Chan Kwon; Choi, Yeong Jin; Lee, Kyo Young; Kang, Jin Hyoung; Kim, Min‐Sik; Hu, Hae Jin

doi:10.1016/j.humpath.2009.09.001

Cited by 32 publications

(23 citation statements)

References 23 publications

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“…As previously described,7 areas rich in tumour cells were identified in each sample by light microscopy of H&E stained sections and used in the TMAs. Tissue cylinders with a diameter of 2 mm were punched from a previously marked area of each donor block and transferred to the recipient block.…”

Section: Methodsmentioning

confidence: 99%

Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast

et al. 2013

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Section: Methodsmentioning

confidence: 99%

Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast

et al. 2013

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“…As described,12 areas of each sample rich in tumour cells were identified by light microscopy of haematoxylin eosin-stained sections and used in the tissue microarrays. Tissue cylinders with a diameter of 2 mm were punched from the previously marked area of each block (donor block) and transferred to a recipient block.…”

Section: Methodsmentioning

confidence: 99%

Clinicopathological significance of CADM4 expression, and its correlation with expression of E-cadherin and Ki-67 in colorectal adenocarcinomas

et al. 2012

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“…Park et al [24] evaluated the expression profi les of cytokeratins 5/6, 8/18, 10, 13, 14, 19, p16 and pRb in 101 patients with SCC of head and neck cancer. They found that cytokeratin 10 was more frequently expressed in oral cavity primary tumours, whereas cytokeratin 19 staining was more frequently observed in tumours originated from the pharynx and larynx.…”

Section: Answers To the Questions Proposedmentioning

confidence: 99%

Unknown primary cancer of the head and neck: a multidisciplinary approach

2011

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The management of patients with cervical lymph node metastases from an unknown primary cancer (CUP) remains a matter of controversy. Although new advanced diagnostic tools, such as positron emission tomography, have recently been introduced in oncology, the frequency of this tumour entity in clinical practice means it is still relevant. Recently introduced molecular profiling platforms may provide biological classification for the primary tissue of origin as well as insights into the pathophysiology of this clinical entity, including the characterisation of the Epstein-Barr virus and human papilloma virus genomas in the metastatic cervical nodes. Due to the lack of randomised trials, a standard therapy has not been identified yet. Although neck dissection followed by post-operative radiotherapy is the most generally accepted approach, there are other curative options that can be used in some patients: neck dissection alone, nodal excision followed by post-operative radiotherapy or radiotherapy alone. A major controversy remains in the target radiation volumes that range from ipsilateral neck irradiation to prophylactic irradiation of all potential mucosal sites and both sides of the neck. Finally, the administration of concurrent chemotherapy is currently being advised for patients with adverse prognostic factors.

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The use of an immunohistochemical diagnostic panel to determine the primary site of cervical lymph node metastases of occult squamous cell carcinoma

Cited by 32 publications

References 23 publications

Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast

Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast

Clinicopathological significance of CADM4 expression, and its correlation with expression of E-cadherin and Ki-67 in colorectal adenocarcinomas

Unknown primary cancer of the head and neck: a multidisciplinary approach

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