The use of antivirals in the treatment of human monkeypox outbreaks: a systematic review

Shamim, Muhammad Aaqib; Padhi, Bijaya Kumar; Satapathy, Prakasini; Veeramachaneni, Sai D; Chatterjee, Chandrima; Tripathy, Snehasish; Akhtar, Naushaba; Pradhan, Anindita; Dwivedi, Pradeep; Mohanty, Aroop; Rodríguez-Morales, Alfonso J.; Sah, Ranjit; Al-Tammemi, Ala’a B.; Al‐Tawfiq, Jaffar A.; Nowrouzi‐Kia, Behdin; Chattu, Vijay Kumar

doi:10.1016/j.ijid.2022.11.040

Cited by 43 publications

(23 citation statements)

References 42 publications

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“…In a study from the United Kingdom, rectal or perianal pain resulted in the hospitalization of 44 (28%) of 156 Mpox cases and 38 (24%) were treated with tecovirimat [24] . Tecovirimat was the most commonly used antiviral with no major safety concerns [25] .…”

Section: Discussionmentioning

confidence: 99%

Clinical features and outcome of human Mpox (Monkeypox) in Saudi Arabia: An observational study of travel-related cases

Assiri

Al‐Tawfiq

Jokhdar

et al. 2023

Journal of Infection and Public Health

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Section: Discussionmentioning

confidence: 99%

Clinical features and outcome of human Mpox (Monkeypox) in Saudi Arabia: An observational study of travel-related cases

Assiri

Al‐Tawfiq

Jokhdar

et al. 2023

Journal of Infection and Public Health

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“…Although vaccines and treatments are available for MPOX management and prevention [ 16 , 17 ], the WHO highlighted the importance of effective public health control measures to halt the spread of MPXV [ 18 ]. This involves enhancing the capacity of healthcare workers (HCWs) to identify cases through implementing early diagnosis and providing systematic effective medical care [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude and Conspiracy Beliefs of Healthcare Workers in Lebanon towards Monkeypox

et al. 2023

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The emergence of a monkeypox (MPOX) outbreak in 2022 represented the most recent recognizable public health emergency at a global level. Improving knowledge and attitude towards MPOX, particularly among healthcare workers (HCWs), can be a valuable approach in public health preventive efforts aiming to halt MPOX virus spread. The aim of the current study was to evaluate the knowledge and attitude of HCWs in Lebanon towards MPOX and to assess their conspiratorial attitude towards emerging virus infections (EVIs). The current study was based on a cross-sectional online survey distributed via Google Forms during September–December 2022 implementing a convenience sampling approach. The final study sample comprised a total of 646 HCWs: physicians (n = 171, 26.5%), pharmacists (n = 283, 43.8%), and nurses (n = 168, 26.0%), among others (n = 24, 3.7%). Variable defects in MPOX knowledge were detected, with a third of the participants having MPOX knowledge above the 75th percentile (n = 218, 33.7%). Satisfactory attitude towards MPOX (>75th percentile) was observed in less than a third of the participants (n = 198, 30.7%), while a quarter of the study sample endorsed conspiracy beliefs towards EVIs at a high level (>75th percentile, n = 164, 25.4%). Slightly more than two thirds of the participants agreed that MPOX vaccination should be used in disease prevention (n = 440, 68.1%). Better levels of MPOX knowledge and attitude were significantly associated with postgraduate education and older age. Physicians had significantly higher MPOX knowledge compared to other occupational categories. Less endorsement of conspiracies towards EVIs was significantly associated with male sex, occupation as a physician, and postgraduate education. Higher MPOX knowledge was associated with better attitude towards the disease. The current study showed unsatisfactory MPOX knowledge among Lebanese HCWs. Educational efforts can be valuable to improve the attitude towards the disease. Despite the relatively low level of embracing conspiracy beliefs regarding EVIs among HCWs in this study compared to previous studies, this area should be considered based on its potential impact on health-seeking behavior.

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“…Corneal ulcerations, in combination with secondary bacterial infections, have been associated with severe ocular complications, including blindness [ 29 ]. Topical trifluridine, when administered together with tecovirimat for mpox patients with varying ophthalmic lesions, has improved the condition without complications [ 30 ]. Vision loss as a complication was reported only among endemic African countries, which could be due to the lack of adequate and appropriate treatment.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic Manifestations of the Monkeypox Virus: A Systematic Review and Meta-Analysis

Gupta

Padhi

et al. 2023

Pathogens

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Background: The accurate estimation of the prevalence of mpox-induced ophthalmic lesions will enable health departments to allocate resources more effectively during the ongoing mpox pandemic. The aim of this meta-analysis was to estimate the global prevalence of ophthalmic manifestations in mpox patients. Methods: A systematic search was carried out in seven databases—Pub Med, Scopus, Web of Science, EMBASE, ProQuest, EBSCOHost, and Cochrane—for studies published on or before 12 December 2022. The pooled prevalence of ophthalmic manifestations was estimated by the random effects model. Risk of bias assessment of the studies and sub-group analysis to explain heterogeneity were undertaken. Results: Overall, 12 studies were included, with 3239 confirmed mpox cases, among which 755 patients reported ophthalmic manifestations. The pooled prevalence of ophthalmic manifestations was 9% (95% confidence interval (CI), 3–24). Studies from Europe reported a very low prevalence of ocular manifestations of 0.98% (95% CI 0.14–2.31), compared to studies from Africa with a substantially higher prevalence of 27.22% (95% CI 13.69–43.26). Conclusions: A wide variation in the prevalence of ocular manifestations among mpox patients was observed globally. Healthcare workers involved in mpox-endemic African countries should be aware of ocular manifestations for early detection and management.

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The use of antivirals in the treatment of human monkeypox outbreaks: a systematic review

Cited by 43 publications

References 42 publications

Clinical features and outcome of human Mpox (Monkeypox) in Saudi Arabia: An observational study of travel-related cases

Clinical features and outcome of human Mpox (Monkeypox) in Saudi Arabia: An observational study of travel-related cases

Knowledge, Attitude and Conspiracy Beliefs of Healthcare Workers in Lebanon towards Monkeypox

Ophthalmic Manifestations of the Monkeypox Virus: A Systematic Review and Meta-Analysis

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