The Use of Aromatherapy to Reduce Chemotherapy-Induced Nausea in Children With Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial

Evans, Anna; Malvar, Jemily; Garretson, Cassie; Kolovos, Eliza Pedroja; Nelson, Mary Baron

doi:10.1177/1043454218782133

Cited by 37 publications

(45 citation statements)

References 15 publications

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“…Pharmacokinetic studies are needed to validate the safety and efficacy of EOs and their bioactive compounds. In fact, even if several papers indicated EOs and their components as safe and not toxic [258][259][260], hepatotoxicity described for monoterpenes and sesquiterpenes, major components of many EOs, should be also considered and should deserve more attention [264]. Further studies on terpene metabolism and toxicity need to be performed to avoid the risk of eventual liver injury.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies also reported the lack of effect of aromatherapy in improving sleep quality in cancer patients or in reducing chemotherapy side effects. In this regard, while non-toxic, non-invasive and well received and tolerated, the inhaled Zingiber officinale EO was not an effective complementary therapy for chemotherapy-induced nausea and vomiting and health-related quality of life neither in children with cancer [258] nor in women with breast cancer [259]. While not showing any harm or adverse events, the study by Sasano's group evidenced no effects of aromatherapy on quality of life, sleep quality, and vital sign during perioperative periods of breast cancer patients [260].…”

Section: Clinical Use Of Eos For Cancer Patientsmentioning

confidence: 97%

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Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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The last two decades have seen the development of effective therapies, which have saved the lives of a large number of melanoma patients. However, therapeutic options are still limited for patients without BRAF mutations or in relapse from current treatments, and severe side effects often occur during therapy. Thus, additional insights to improve treatment efficacy with the aim to decrease the likelihood of chemoresistance, as well as reducing side effects of current therapies, are required. Natural products offer great opportunities for the discovery of antineoplastic drugs, and still represent a useful source of novel molecules. Among them, essential oils, representing the volatile fraction of aromatic plants, are always being actively investigated by several research groups and show promising biological activities for their use as complementary or alternative medicine for several diseases, including cancer. In this review, we focused on studies reporting the mechanism through which essential oils exert antitumor action in preclinical wild type or mutant BRAF melanoma models. We also discussed the latest use of essential oils in improving cancer patients’ quality of life. As evidenced by the many studies listed in this review, through their effect on apoptosis and tumor progression-associated properties, essential oils can therefore be considered as potential natural pharmaceutical resources for cancer management.

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Section: Discussionmentioning

confidence: 99%

Section: Clinical Use Of Eos For Cancer Patientsmentioning

confidence: 97%

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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“…During the past few decades, different complementary and alternative therapies have been applied to manage nausea and vomiting associated with active treatment among children with cancer 26 29–36. Nevertheless, no systematic review has yet been performed to compare the effectiveness of these therapies.…”

Section: Discussionmentioning

confidence: 99%

“…According to the National Institutes of Health,28 CAM refers to medical products and practices that are not regarded as part of standard medical care. The types of CAM most commonly used to control nausea and vomiting among children with cancer include acupressure,26 29 30 acupuncture,31 hypnotherapy,32 33 aromatherapy34 35 and creative arts therapy 36…”

Section: Introductionmentioning

confidence: 99%

Systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer: a study protocol

Lam

Chung

et al. 2019

BMJ Open

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IntroductionNausea and vomiting are two most common symptoms reported by children with cancer when they undergo active treatment. However, pharmacological treatment is not sufficient to manage these two symptoms, with over 40% of children still experience nausea and vomiting after receiving antiemetics. There has been an exponential growth of studies to demonstrate the effectiveness of different complementary complementary medicine (CAM) to control nausea and vomiting during cancer treatment. Appropriate application of CAM enhances the effectiveness of antiemetics, thus reducing the symptom burden on children as well as improving their general condition and quality of life during cancer treatment. Nevertheless, it remains unclear which CAM is the best approach to help children to prevent or reduce nausea and vomiting during and after cancer treatment. This paper describes a protocol for identifying, analysing and synthesising research evidence on the effectiveness of CAM on nausea and vomiting in children with cancer.Methods and analysisA total of 10 databases will be searched to identify appropriate literature: MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, CINAHL, PsycINFO, LILACS, OpenSIGLE, the Chinese Biomedical Literature Database, the Chinese Medical Current Contents and the Chinese National Knowledge Infrastructure. All randomised controlled trials which meet the inclusion criteria will be included. The primary outcome is the changes in nausea and vomiting either assessed by self-reported and/or objective measures. Review Manager 5.3 will be used to synthesise the data, calculate the treatment effects, perform any subgroup analysis and assess the risk of bias.Ethical and disseminationThe results will be presented at international conferences and published in peer-reviewed journals. As no individual data will be involved in this review, ethical approval is not required.PROSPERO registration numberCRD42019135404.

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“…In a small pediatric double-blind study of ginger aromatherapy for the prevention of chemotherapy-induced nausea (CIN), there was no difference observed among patients who did and did not receive aromatherapy. However, it is one of few studies to have used a standardized nausea tool, the PeNAT [51]. Ginger aromatherapy was reported to be well-tolerated and enjoyed by patients and caregivers alike.…”

Section: Integrative Medicine Options For Cinv Prophylaxis In Childrenmentioning

confidence: 99%

Latest Update on Prevention of Acute Chemotherapy-Induced Nausea and Vomiting in Pediatric Cancer Patients

2019

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Purpose of Review Chemotherapy-induced nausea and vomiting (CINV) is a common cause of acute morbidity that impacts quality of life in children receiving cancer treatment. Here, we review the evolution of CINV prophylaxis guidelines in children, with an emphasis on the literature published in the last 5 years, to bring the reader up to date. Recent Findings Recent studies have led to the adoption of the "triple therapy" regimen of antiemetic prophylaxis (a 5-HT3 antagonist, dexamethasone, and a neurokinin-1 antagonist) as the backbone of recommendations for the prevention of CINV in children. Areas of new data include the addition of aprepitant and inclusion of palonosetron as a non-inferior 5-HT3 antagonist. In addition, there are emerging pediatric data informing patient-derived risk factors associated with CINV risk and classification of antineoplastic drugs based on emetogenicity. Summary Several recent pediatric studies have shaped published guidelines for CINV prophylaxis in children. Keywords Nausea. Vomiting. Antiemetic. Chemotherapy-induced nausea and vomiting. CINV. Supportive care. Guidelines Classification of Drugs by Emetogenicity The inherent emetogenicity of a drug regimen is the basis of current guidelines addressing CINV prophylaxis in children. Cancer drugs are classified as either minimal, low, medium, or This article is part of the Topical Collection on Pediatric Oncology

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The Use of Aromatherapy to Reduce Chemotherapy-Induced Nausea in Children With Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 37 publications

References 15 publications

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer: a study protocol

Latest Update on Prevention of Acute Chemotherapy-Induced Nausea and Vomiting in Pediatric Cancer Patients

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