The Use of Artificial Respiration in Pulmonary Emphysema Accompanied by High Carbon Dioxide Levels 1

Boutourline-Young, Harben; Whittenberger, James L.

doi:10.1172/jci102498

Cited by 83 publications

(12 citation statements)

References 17 publications

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“…A tracheotomy was done in addition in three of those cases. Several reports have related good results with this kind of management of patients with carbon dioxide narcosis (7,34,37). Other authors state that the use of respirators has been unsuccessful (13,61,79).…”

Section: Mechanical Respiratorsmentioning

confidence: 97%

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Carbon Dioxide Intoxication: The Clinical Syndrome, Its Etiology and Management With Particular Reference to the Use of Mechanical Respirators

Sieker¹

1971

Arch Intern Med

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Section: Mechanical Respiratorsmentioning

confidence: 97%

“…Carbon dioxide intoxication is now recognized as a syndrome that can occur in persons with disorders which greatly reduce alveolar ventilation (3,7,13,14,33,37,42,61,63,70,79). The symptoms and clinical findings in this condition vary in character and severity and may simulate other disease entities.…”

Section: Introductionmentioning

confidence: 99%

Carbon Dioxide Intoxication: The Clinical Syndrome, Its Etiology and Management With Particular Reference to the Use of Mechanical Respirators

Sieker¹

1971

Arch Intern Med

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“…NIV for CRF was first described in 1951 [17] and later in 1977 [18]. The positive impact on resting blood gas levels has been extensively described for obstructive [2,3,4, 19, 20] and restrictive [2,3,4, 8, 21] pulmonary disease.…”

Section: Discussionmentioning

confidence: 99%

Exercise Endurance before and after Long-Term Noninvasive Ventilation in Patients with Chronic Respiratory Failure

Schönhofer

Dellweg²,

Suchi³

et al. 2007

Respiration

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Background: Noninvasive mechanical ventilation (NIV) is known to reduce hypoventilation and improves respiratory and peripheral muscle endurance in patients with chronic respiratory failure (CRF) due to thoracic restriction. Objectives: To compare the effect of short-term NIV on endurance in patients with CRF due to thoracorestriction and chronic obstructive pulmonary disease (COPD) and to evaluate differences in spiroergometric data during exercise testing. Methods: Thirty-five patients with CRF due to COPD and 24 patients with CRF due to thoracorestriction entered the trial. Constant work rate exercise testing at 75% of the maximal workload, pulmonary function and arterial blood gas testing were performed before and after 3 months of NIV. Measurements were compared between and within groups. Results: The non-COPD group increased their exercise time significantly from 4.7 ± 1.81 to 6.59 ± 3.15 min (p = 0.0032). There was no change in the COPD group (4.57 ± 2.19 min before and 5.39 ± 3.09 min after NIV, p = 0.09). CO₂ levels at rest fell in both groups (COPD 52.30 ± 7.77 to 46.06 ± 4.61 mm Hg and non-COPD 47.82 ± 5.19 to 43.79 ± 4.15 mm Hg). While COPD patients increased their minute ventilation (13.47 ± 2.73 to 14.88 ± 2.67 l/min), non-COPD patients decreased their oxygen uptake from 6.27 ± 1.61 to 5.54 ± 1.35 ml/kg. Conclusions: NIV improved endurance only in the non-COPD group. This and the reduction in CO₂ are achieved by lowering energetic requirements. COPD patients though decreased their resting CO₂ by increased minute ventilation.

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“…BOUTOURLINE-YOUNG and WHITTENBERGER [72] described two cases of pulmonary emphysema with hypercapnia and hypoxaemia treated in a body respirator; one patient died and the other survived and was able to return to his former occupation. STONE et al [73] successfully treated by iron lung three patients with chronic pulmonary disease during ARF.…”

Section: Arf In Copd With Chronic Respiratory Insufficiencymentioning

confidence: 99%

Negative pressure ventilation in the treatment of acute respiratory failure: an old noninvasive technique reconsidered

Corrado¹,

Gorini²,

Villella³

et al. 1996

European Respiratory Journal

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Negative pressure ventilation in the treatment of acute respiratory failure: an old noninvasive technique reconsidered. A. Corrado, M. Gorini, G. Villella, E. De Paola. ©ERS Journals Ltd 1996. ABSTRACT: Noninvasive mechanical ventilatory techniques include the use of negative and positive pressure ventilators. Negative pressure ventilators, such as the "iron lung", support ventilation by exposing the surface of the chest wall to subatmospheric pressure during inspiration; whereas, expiration occurs when the pressure around the chest wall increases and becomes atmospheric or greater than atmospheric.In this review, after a description of the more advanced models of tank ventilators and the physiological effects of negative pressure ventilation (NPV), we summarize the recent application of this old technique in the treatment of acute respiratory failure (ARF). Several uncontrolled studies suggest that NPV may have a potential therapeutic role in the treatment of acute on chronic respiratory failure in patients with chronic obstructive pulmonary disease and restrictive thoracic disorders, reducing the need for endotracheal intubation. In the paediatric field, after substantial technical improvement, NPV has been successfully reintroduced for the treatment of ARF due to neonatal distress syndrome and bronchopulmonary dysplasia, and for the weaning from positive pressure ventilation in intubated patients.The positive results of these reports need to be formally confirmed by further prospective and controlled studies before recommending the generalized use of negative pressure ventilation in acute respiratory failure as a standard of care.

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The Use of Artificial Respiration in Pulmonary Emphysema Accompanied by High Carbon Dioxide Levels 1

Cited by 83 publications

References 17 publications

Carbon Dioxide Intoxication: The Clinical Syndrome, Its Etiology and Management With Particular Reference to the Use of Mechanical Respirators

Carbon Dioxide Intoxication: The Clinical Syndrome, Its Etiology and Management With Particular Reference to the Use of Mechanical Respirators

Exercise Endurance before and after Long-Term Noninvasive Ventilation in Patients with Chronic Respiratory Failure

Negative pressure ventilation in the treatment of acute respiratory failure: an old noninvasive technique reconsidered

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