The Use of Autofluorescent Stomatoscopy as a Screening Method of Diagnostics of Precancer States and Oncological Diseases of Mucous Membrane of the Mouth at a Stomatological Attendance

FILIMONOVA, L.B.; Mezhevikina, G.S.; Marshuba, L.O.

doi:10.23888/hmj20208180-85

Cited by 4 publications

(2 citation statements)

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“…Since cancer screening has high sensitivity (98%), against the background of relative specificity (75%), the issues related to the differential diagnosis of the pathology are still debatable [27][28][29][30][31]. The use of cytological methods at the stages of diagnosis reduces the risk of possible false positive and false negative results, and is the basis for further research for effective diagnostic methods [32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Minimally Invasive Optical and Cytological Technologies in the Diagnostic Algorithm for Pathological Processes of the Oral Mucosa

Гажва¹,

Kalinkin²,

Ibragimova³

et al. 2023

ArveMED

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Despite scientific and technological progress and the emergence of modern diagnostic methods, the number of neglected cases of oncopathology has been increasing annually, and its mortality rate has been also increasing. Thus, over the past five years in Russia it increased by 12.4%. Moreover, the one-year mortality of patients with oral mucosa oncological pathology (OMC) is over 50 %, the 5-year survival rate is 24 % for men and 37 % for women. One of the demanded areas of effective medicine is the use of minimally invasive organ-preserving diagnostic tests, which unfortunately have not been widely used in practical dentistry. The purpose of the study is to improve early diagnostic efficiency for detecting pathological processes in the oral mucosa through the combined use of optical and cytological methods for its study. We examined 350 patients of both sexes aged from 20 to 67 years within consultation appointments with the aim of specifying the diagnosis and determining the algorithm of treatment. Methods: clinical, analytical, physical (autofluorescence dentistry), laboratory (liquid cytology), statistical. Conclusion: combined use of methods of autofluorescence stomatoscopy and liquid cytology increases efficiency of diagnostic stage, reduces risk of neglected stages of pathological processes, improves quality of patient's life.

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Section: Introductionmentioning

confidence: 99%

Minimally Invasive Optical and Cytological Technologies in the Diagnostic Algorithm for Pathological Processes of the Oral Mucosa

Гажва¹,

Kalinkin²,

Ibragimova³

et al. 2023

ArveMED

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“…The current literature witnesses that clinical examination still remains a major method employed in case of suspected malignancy [16,17]. This method, however, does not allow delivering a final diagnosis, while most patients with suspected OM cancer are referred to an oncologist for a biopsy, which, in turn, may result in excessive diagnostics [18,19]. OM neoplasms biopsy is an invasive method, which involves obtaining tissue samples for histological examination, thus trying to ensure differential diagnostics and establishing a reliable diagnosis [20,27,28].…”

Section: Introductionmentioning

confidence: 99%

Improved Diagnosisfor Oral Mucosal Tumorsin the Dentist’s Office

Postnikov¹,

Gabrielyan²,

Trunin³

et al. 2021

AREM

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Based on currently available literature, clinical examination remains the major method when handling cases of suspected malignancy. However, this method does not allow diagnosing cancer, due to which a large group of patients with possible oral mucosa cancer are referred to an oncologist. The search and use of affordable non-invasive methods for early diagnosis of oral mucosa tumors is an urgent issue facing the health system. The study involved analyzing 134 records of outpatients examined at the Samara Regional Oncological Clinic who were referred by dentists within 2014-2019 from the local polyclinic in Samara due to detection of tumors in oral mucosa and who underwent a biopsy. The patients were divided into two groups according to the examination methods. The inclusion criteria were: detection of various superficial oral mucosa neoplasms; referral from the dentist. The exclusion criteria were as follows: patients with submucosal oral cavity neoplasms referred to the oncologist by other medical specialists or self-referred patients. The control group included 63 patients who, after a conventional examination (including interview, examination, palpation), underwent an incisional biopsy followed by morphological examination at the oncologist’s office. In the major group, in 71 patients at their respective initial dental appointments a special examination algorithm was applied. This algorithm entailed an assessment of the identified risk factors. Indications for biopsy were identified using the histological verification index (HVI). Apart from the conventional examination methods (interview, examination, palpation), autofluorescence stomatoscopy was used, this being done for the purpose of differential diagnostics of inflammation, precancerous and malignant issues, depending on the glow type. In the main group, the initial stages of oral mucosa cancer were detected in 17 patients after biopsy; in the control group – in 4 patients (p=0.004). The developed algorithm used for scoring the patient’s clinical examination data combined with autofluorescence stomatoscopy allowed diagnosing accurately (90% of reliability) precancerous and cancerous diseases, as well as to use invasive research methods (biopsy) strictly following the indications. Aim of study: to improve diagnosis of oral mucosa neoplasms through improvement of the examination algorithm.

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The Effectiveness of Autofluorescence Stomatoscopy as the Main Method of Early Diagnosis of Precancerous Diseases of the Oral Mucosa

Popov,

Karyakin,

Karyakina

et al. 2024

Actual Problems in Dentistry

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Importance Currently, the prevalence of various diseases of the oral mucosa in the world has increased significantly (from 15.2% to 49.1%). Oncological pathology should be attributed to a separate group of diseases. In order to actively identify precancerous processes of the oral cavity, along with traditional methods of examination of the maxillofacial region, oncoscreening of the mucous membrane and organs of the oral cavity is mandatory. One of the possible methods of oncoscreening is autofluorescence stomatoscopy. Objectives To clarify the effectiveness of autofluorescence stomatoscopy as the main method of early diagnosis of precancerous diseases of the oral mucosa, its advantages and disadvantages. Methods In the process of investigating the effectiveness of autofluorescence stomatoscopy, methods of qualitative analysis and synthesis of available scientific literature on autofluorescence stomatoscopy were used. Conclusions It is concluded that the use of autofluorescence stomatoscopy for the early diagnosis of precancerous diseases of the oral mucosa remains controversial. Some clinicians believe that the introduction of autofluorescence stomatoscopy into the practice of a dentist as an additional method of oncoscreening of the oral mucosa is not only relevant, but also necessary; and the analysis of the light glow corresponds to the results of a biopsy. However, other researchers have concluded that the AFS-method will not replace the gold standard of histological examination, due to the low specificity of the method, the study can lead to overdiagnosis, and it can only be used by experienced clinicians to find the boundaries of precancerous lesions of the oral cavity for taking a biopsy in an altered mucous membrane.

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The Use of Autofluorescent Stomatoscopy as a Screening Method of Diagnostics of Precancer States and Oncological Diseases of Mucous Membrane of the Mouth at a Stomatological Attendance

Abstract: To cite this article: Filimonova LB, Mezhevikina GS, Marshuba LO. The use of autofluorescent stomatoscopy as a screening method of diagnostics of precancer states and oncological diseases of mucous membrane of the mouth at a stomatological attendance.

Cited by 4 publications

References 1 publication

Minimally Invasive Optical and Cytological Technologies in the Diagnostic Algorithm for Pathological Processes of the Oral Mucosa

Minimally Invasive Optical and Cytological Technologies in the Diagnostic Algorithm for Pathological Processes of the Oral Mucosa

Improved Diagnosisfor Oral Mucosal Tumorsin the Dentist’s Office

The Effectiveness of Autofluorescence Stomatoscopy as the Main Method of Early Diagnosis of Precancerous Diseases of the Oral Mucosa

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