The use of autologous fibronectin in the surgical repair of through‐and‐through furcation lesions in man A pilot study

Yeung, Stephen; Boyatzis, S.

doi:10.1111/j.1600-051x.1990.tb01097.x

Cited by 7 publications

(9 citation statements)

References 21 publications

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“…Thirty‐four articles were excluded after full‐text review (Table 3). 10‐12,16,30‐59 A final selection of 150 articles was made, of which six were systematic reviews, 2,60‐64 109 were clinical trials, 53,65‐172 27 were case series, 173‐199 and eight were case reports 200‐207 . No cohort studies were identified.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 24 clinical trials 149‐172 and 13 case series 185‐197 were non‐classifiable, as defined in Materials and Methods (Tables 4 and 5). Of the 85 remaining clinical trials, 53,65‐148 eight reported outcomes after applying regenerative therapy on maxillary facial/interproximal Class II furcation defects, 76,87,92,100,105,140,148,208 68 on mandibular facial/lingual Class II furcation defects, 65‐68,70‐72,75,77,78,80‐85,87‐90,93‐99,101‐104,106,107,110‐112,114‐122,124‐139,141‐147 one on maxillary Class III furcation defects, 91 nine on mandibular Class III furcation defects, 69,73,74,77,86,108,109,113,123 and one on maxillary premolars presenting Class I and Class II furcation defects 79 . Of the 14 selected case series, two reported on the treatment of maxillary facial/interproximal Class II furcation defects, 177,180 11 on mandibular facial/lingual Class II furcation defects, 173‐176,178‐184 and two on mandibular Class III furcation defects 198,199 .…”

Section: Resultsmentioning

confidence: 99%

“…All of the six selected studies that compared the effectiveness of regenerative therapy with non‐regenerative approaches reported on clinical outcomes 69,73,74,77,108,113 . Interestingly, only one study included the use of a membrane in the test group 69 .…”

Section: Resultsmentioning

confidence: 99%

“…The results in these studies are conflicting, because two of them reported significantly superior outcomes in the test group, 77,108 whereas the other two clinical trials showed no benefit associated with the use of a bone graft 74,113 . In the remaining clinical trial, OFD was compared with OFD in combination with citric acid for root conditioning and autologous fibronectin 73 . Both groups were associated with a moderately positive response, with no differences among groups.…”

Section: Resultsmentioning

confidence: 99%

“…A total of nine articles reporting clinical trials aimed at assessing the effectiveness of regenerative therapies in the treatment of mandibular Class III furcation defects were identified (see supplementary Table 8 in online Journal of Periodontology). 69,73,74,77,86,108,109,113,123 Six studies compared a regenerative approach (test) with one non-regenerative surgical intervention consisting of OFD or CPF (control). 69,73,74,77,108,113 The other three studies compared at least two different regenerative approaches with each other.…”

Section: Available Evidence On Specific Clinical Scenariosmentioning

confidence: 99%

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Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop

Ávila‐Ortiz

Buitrago

Reddy

2015

Journal of Periodontology

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Background: The aim of this review is to present the available evidence regarding the effectiveness of different regenerative approaches for the treatment of furcation defects in specific clinical scenarios compared with conventional surgical therapy to provide clinical guidelines for the therapeutic management of furcation defects and to identify priorities for future research that may advance the understanding of periodontal regenerative medicine.Methods: A comprehensive search based on predetermined eligibility criteria was conducted to identify human original studies and systematic reviews on the topic of periodontal regeneration of furcation defects. Two reviewers independently screened the title and abstract of the entries yielded from the initial search. Subsequently, both reviewers read the full-text version of potentially eligible studies, made a final article selection, and extracted the data of the selected studies considering specific clinical scenarios. The clinical scenarios contemplated in this review included the following: 1) facial and interproximal Class I defects in maxillary molars; 2) facial and lingual Class I defects in mandibular molars; 3) facial and interproximal Class II furcation defects in maxillary molars; 4) facial and lingual Class II furcation defects in mandibular molars; 5) Class III furcation defects in maxillary molars; 6) Class III furcation defects in mandibular molars; and 7) Class I, II, or III furcation defects in maxillary premolars. Endpoints of interest included different clinical, radiographic, microbiologic, histologic, and patient-reported outcomes.Results: The initial search yielded a total of 1,500 entries. The final selection consisted of 150 articles, of which six were systematic reviews, 109 were clinical trials, 27 were case series, and eight were case reports. A summary of the main findings of previously published systematic reviews and the available evidence relative to the indication of regenerative approaches for the treatment of furcation defects compared with conventional surgical therapy are presented. Given the marked methodologic heterogeneity and the wide variety of materials and techniques applied in the selected clinical trials, the conduction of a meta-analysis was not viable.Conclusions: On the basis of the reviewed evidence, the following conclusions can be drawn. 1) Periodontal regeneration has been demonstrated histologically and clinically for the treatment of maxillary facial or interproximal and mandibular facial or lingual Class II furcation defects. 2) Although periodontal regeneration has been demonstrated histologically for the treatment of mandibular Class III defects, the evidence is limited to one case report. 3) Evidence supporting regenerative therapy in maxillary Class III furcation defects in maxillary molars is limited to clinical case reports. 4) In Class I furcation defects, regenerative therapy may be beneficial in certain clinical scenarios, although most Class I furcation defects may be successfully treated with non-regen...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Available Evidence On Specific Clinical Scenariosmentioning

confidence: 99%

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Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop

Ávila‐Ortiz

Buitrago

Reddy

2015

Journal of Periodontology

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Osteopontin and bone sialoprotein expression in regenerating rat periodontal ligament and alveolar bone

1996

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Background Osteopontin (OPN) and bone sialoprotein (BSP) are differentially expressed over time in bone formation and remodelling. We have examined the expression of these proteins as phenotypic markers in studies of periodontal ligament (PL) and alveolar bone (AB) regeneration. Methods Window wounds (0.6 mm in diameter through alveolar bone) with either preservation or extirpation of PL were prepared under general anaesthesia in 30 Wistar male rats. Animals were killed on days 1, 3, 7, 14, and 28 after surgery, and OPN and BSP were detected with mouse monoclonal antirat antibodies. Results In regenerating alveolar bone, OPN was first detected on day 3, prior to the expression of BSP. However, only OPN could be detected in the PL where it localized to the border with the AB. Compared to wounds with PL extirpation, wounds with preservation of PL exhibited BSP staining within the AB compartment of the wound site in a significantly shorter period of time (day 7) and exhibited intense OPN and B P staining by day 28. Conclusions These studies show that early OPN and BSP expression and bone regeneration are enhanced by preservation of the PL and that during wound healing the PL contains cells that transiently express some osteoblastic protein markers but not mineralization. © 1996 Wiley‐Liss, Inc.

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Report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Jendresen¹,

Allen²,

Klooster³

et al. 1991

The Journal of Prosthetic Dentistry

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Subjects of the past decade in the dental literature are reflected in this year's Committee report. We note the decrease in the prevalence of caries, the influence of dental implants, the advancements in dental materials, and the continued efforts to control adhesive events in the oral cavity. This year we included comments from and about many significant review articles published this past year. The Committee continues to be concerned about the quality of some of the work reported and the quality of the reporting. We have attempted to select the distinguished work, that which provides new information to our profession. The subjects covered include pulp biology, caries prevention, periodontics, implants, craniomandibular function and dysfunction, occlusion, and dental materials.

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The use of autologous fibronectin in the surgical repair of through‐and‐through furcation lesions in man A pilot study

Cited by 7 publications

References 21 publications

Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop

Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop

Osteopontin and bone sialoprotein expression in regenerating rat periodontal ligament and alveolar bone

Report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

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