The use of autologous mesenchymal stem cells to improve the functional state of the liver after its resection (clinical observation)

Abstract

The article provides a clinical observation with an assessment of biochemical indicators and changes in liver volume in the patient after liver resection. A peculiarity of this clinical observation is that intraoperative (during liver resection) administration of autologous mesenchymal stem cells was performed on this patient. In the postoperative period, the patient was not given protein and hepatotropic preparations. As a result of the use of cellular technologies, on the 15th day after the operation, the patient recovered protein function of the liver; 10 days after the operation, the level of prothrombin time and transaminases normalized; on day 5 after the operation, alkaline phosphatase and GGTP were normalized. Previously, we proved that autologous mesenchymal stem cells introduced through the portal vein of the liver are fixed directly in the liver tissue. These results were confirmed by magnetic resonance imaging. The introduced cell structures were visualized by pre-labeling them with iron oxide nanoparticles. The search for new ways to restore liver function after resections is a significant task in liver surgery, which in the future will help to improve the postoperative results of treatment of patients and reduce the bed-day.