The Use of Autologous Platelet-Rich Plasma (Platelet Gel) and Autologous Platelet-Poor Plasma (Fibrin Glue) in Cosmetic Surgery

Man, Daniel; Plosker, Harvey; Winland-Brown, Jill E.

doi:10.1097/00006534-200101000-00038

Cited by 116 publications

(153 citation statements)

References 4 publications

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“…Peripheral blood PLTs are a well known starting material to obtain PG, a blood component that can be used in several regenerative treatments including chronic wound, skin and soft tissue repair [21]. More recently, PG has been considered also for breast cosmetic augmentation and in anti-aging medicine [22]. Several methods for PG preparation have been reported in the literature, some based on commercially available kits and some on local laboratory procedures.…”

Section: Discussionmentioning

confidence: 99%

Platelet gel from cord blood: A novel tool for tissue engineering

2010

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Recent findings show that growth factors (GF) play a relevant role in regenerative medicine. Platelets (PLT) may be used as “drug-stores” of GF that can be released upon activation by PLT granules. In this context, PLT gel (PG) from peripheral blood is currently used to improve tissue healing in orthopedic, oral maxillofacial and dermatologic surgery. Recent findings on multiple biological properties of human umbilical cord blood (CB) and its high level of viral safety prompted us to investigate the characteristics of its PLTs and the possibility to produce PLT gel from cord blood. Our study shows that CB PG releases high levels of vascular endothelial growth factor (VEGF) and platelet-derived growth factor-BB (PDGF-BB), substantial amounts of fibroblast growth factor (FGF), hepatocyte growth factor (HGF) and transforming growth factor-beta 1 (TGFbeta1), and minimal amounts of PDGF-AB. These findings suggest that CB PG can be a preferable tool for tissue engineering applications where high levels of VEGF and PDGF may be desirable.

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Section: Discussionmentioning

confidence: 99%

Platelet gel from cord blood: A novel tool for tissue engineering

2010

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“…A combined spray of PRP or PPP and activation solution is commonly directed at the wound bed to cover and seal the wound surface as the gel is forming. 4,13 It is important that appropriate hemostasis occurs during surgery to minimize risk to the patient and to help ensure a favorable clinical outcome. Although PRP, PPP, and related commercially available fibrin sealants are often applied to seal surgical wounds to help reduce bleeding, this ability has not been well quantified.…”

mentioning

confidence: 99%

Platelet-Rich and Platelet-Poor Plasma

Pietrzak¹,

Kang

et al. 2007

Journal of Craniofacial Surgery

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Hemostasis is important for any surgical procedure. One method uses autologous platelet-rich and/or platelet-poor plasma sprayed on the wound site. Although effective, there are little quantitative data available to fully document the extent to which these autologous products function as hemostats. Also, limitations in current animal models make quantitative study of topical hemostats difficult. A porcine partial-thickness skin wound model was developed to compare the hemostatic ability of these treatments with untreated control wounds. Rectangular partial-thickness dermal wounds were created in the back of a pig, which was then sprayed with activated platelet-rich plasma, activated platelet-poor plasma, or left untreated. Bleeding was quantified by two methods: 1) gravimetric measurement of exudate transfer to a sponge over a 15-minute interval, and 2) iron assay of the exudate over this same interval. Values for treated wounds were normalized to those of control wounds to minimize interanimal variability. Both gravimetric and iron assay measurements demonstrated that platelet-rich plasma was effective within 5 minutes after application with normalized bleeding values of approximately 35% and 20%, respectively, of the untreated controls. Corresponding values for platelet-poor plasma were approximately 90% and 65%, respectively, with differences only significant for the iron assay method measured on 10- and 15-minute wound exudate. Although both platelet-rich and platelet-poor plasma demonstrated hemostatic potential, the effect was more robust with the former. Iron assay was a more accurate method of measuring bleeding than gravimetric analysis.

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“…PRP is a natural source of GFs, with PDGFs, TGFs, FGFs, VEGFs, and EGF stored in the a-granules of platelets. Platelets activated by factors such as thrombin and calcium release those GFs from the a-granules of platelet [6,7]. The integration of a wide variety of GFs may be important in tissue engineering strategy in an effort to mimic the natural environments of tissue formation [24].…”

Section: Discussionmentioning

confidence: 99%

“…More recent works have demonstrated the role of PRP in bone graft, teeth osteosynthesis, and wound healing [4,5]. Clinical studies have also documented the efficacy and safety of using PRP in hard-and soft-tissue argumentation by stimulating and enhancing native repair and regeneration processes [6][7][8]. However, GFs in PRP are diffusive in vivo, and half-life times of their biological activities are short [9].…”

Section: Introductionmentioning

confidence: 99%