The Use of Biomaterials in Internal Radiation Therapy

Milborne, Ben; Arafat, Abul; Layfield, Rob; Thompson, Alexander; Ahmed, Ifty

doi:10.21926/rpm.2002012

Cited by 4 publications

(4 citation statements)

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“…Radiation can directly damage DNA or indirectly damage it through the generation of reactive oxygen species (ROS). (c) DNA damage can occur as a result of single-strand breaks (SSB), double-strand breaks (DSB), or other interactions with DNA and proteins (Reproduced with permission from ref . Copyright 2020, LIDSEN Publishing Inc. published under a Creative Common CC-BY-NC License).…”

Section: Radioactive Microspheresmentioning

confidence: 99%

“…112 Figure 13 illustrates the interaction of different types of particulate radiation with DNA and the LET values influenced by the amount of particulate radiation that passes to the material. 112,114 Yttrium ( 90 Y) is the most widely used radioactive moiety in several targeted radioimmunotherapies to treat a variety of solid organs and hematological malignancies. This βemitter forms the premise for radioembolization as it enables the radiation exposure zone to the vicinity of the local tumor tissue with tolerable levels of nontumorous exposure.…”

Section: Radionuclides and Doping Techniques 221 Radionuclidementioning

confidence: 99%

“…In contrast, the most extensively used radionuclides for a broad series of radiotherapeutic applications are radionuclides emitting β-particles due to their availability and suitability to treat large tumor volumes. , In contrast with α-particle emitters, β-particle emitters produce a nearly homogeneous radiation dose distribution Figure illustrates the interaction of different types of particulate radiation with DNA and the LET values influenced by the amount of particulate radiation that passes to the material. , Yttrium ( 90 Y) is the most widely used radioactive moiety in several targeted radioimmunotherapies to treat a variety of solid organs and hematological malignancies. This β-emitter forms the premise for radioembolization as it enables the radiation exposure zone to the vicinity of the local tumor tissue with tolerable levels of nontumorous exposure …”

Section: Radioactive Microspheresmentioning

confidence: 99%

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The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

Nuzulia,

Mart,

Ahmed

et al. 2024

ACS Biomater. Sci. Eng.

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Embolization therapy involving biomaterials has improved the therapeutic strategy for most liver cancer treatments. Developing biomaterials as embolic agents has significantly improved patients' survival rates. Various embolic agents are present in liquid agents, foam, particulates, and particles. Some of the most applied embolic agents are microparticles, such as microspheres (3D micrometer-sized spherical particles). Microspheres with added functionalities are currently being developed for effective therapeutic embolization. Their excellent properties of high surface area and capacity for being loaded with radionuclides and alternate active or therapeutic agents provide an additional advantage to overcome limitations from traditional cancer treatments. Microspheres (nonradioactive and radioactive) have been widely used and explored for localized cancer treatment. Non-radioactive microspheres exhibit improved clinical performance as drug delivery vehicles in chemotherapy due to their controlled and sustained drug release to the target site. They offer better flow properties and are beneficial for the ease of delivery via injection procedures. In addition, radioactive microspheres have also been exploited for use as an embolic platform in internal radiotherapy as an alternative to cancer treatment. This short review summarizes the progressive development of non-radioactive and radioactive embolic microspheres, emphasizing material characteristics. The use of embolic microspheres for various modalities of therapeutic arterial embolization and their impact on therapeutic performance are also discussed.

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Section: Radioactive Microspheresmentioning

confidence: 99%

Section: Radionuclides and Doping Techniques 221 Radionuclidementioning

confidence: 99%

Section: Radioactive Microspheresmentioning

confidence: 99%

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The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

Nuzulia,

Mart,

Ahmed

et al. 2024

ACS Biomater. Sci. Eng.

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“…In the case of polymer-based microspheres, applications have included targeted drug delivery, tissue engineering and regenerative medicine [ 21 , 22 ]. Whilst ceramic and glass-based microspheres are more commonly associated with tissue regeneration applications, e.g., bone repair [ 23 , 24 ], orthopaedics [ 25 ], dental [ 26 ] and cancer therapeutics (radiotherapy) [ 27 ], along with magnetic hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

Optimisation of the Flame Spheroidisation Process for the Rapid Manufacture of Fe3O4-Based Porous and Dense Microspheres

et al. 2023

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The rapid, single-stage, flame-spheroidisation process, as applied to varying Fe3O4:CaCO3 powder combinations, provides for the rapid production of a mixture of dense and porous ferromagnetic microspheres with homogeneous composition, high levels of interconnected porosity and microsphere size control. This study describes the production of dense (35–80 µm) and highly porous (125–180 µm) Ca2Fe2O5 ferromagnetic microspheres. Correlated backscattered electron imaging and mineral liberation analysis investigations provide insight into the microsphere formation mechanisms, as a function of Fe3O4/porogen mass ratios and gas flow settings. Optimised conditions for the processing of highly homogeneous Ca2Fe2O5 porous and dense microspheres are identified. Induction heating studies of the materials produced delivered a controlled temperature increase to 43.7 °C, indicating that these flame-spheroidised Ca2Fe2O5 ferromagnetic microspheres could be highly promising candidates for magnetic induced hyperthermia and other biomedical applications.

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Development of samarium-doped phosphate glass microspheres for internal radiotheranostic applications

Arjuna,

Milborne,

Putra

et al. 2024

International Journal of Pharmaceutics

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The Use of Biomaterials in Internal Radiation Therapy

Cited by 4 publications

References 0 publications

The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

Optimisation of the Flame Spheroidisation Process for the Rapid Manufacture of Fe3O4-Based Porous and Dense Microspheres

Development of samarium-doped phosphate glass microspheres for internal radiotheranostic applications

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