The use of blood products in paediatric oncology units in the UK

Nathan, Martina; Selwood, Karen

doi:10.7748/paed.18.7.14.s20

Cited by 2 publications

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“…[6][7][8][9] This survey is unique in revealing both interinstitutional differences and intrainstitutional differences in transfusion thresholds for HSCT versus general oncology patients.…”

Section: Discussionmentioning

confidence: 99%

“…Other specialties with limited evidence-based guidelines have shown variation in transfusion practices; surveys of neonatologists, pediatric intensivists, and pediatric oncologists illustrate these diverse practices. [6][7][8][9] In 2005, Wong et al 9 published a survey of members of the American Society of Pediatric Hematology and Oncology (ASPHO) with respect to the transfusion practices of pediatric oncologists. That survey, although comprehensive in its scope, was directed at individual clinicians and may not have accurately represented institutional differences.…”

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confidence: 99%

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A Survey of Transfusion Practices in Pediatric Hematopoietic Stem Cell Transplant Patients

Bercovitz

Quinones

2013

Journal of Pediatric Hematology/Oncology

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Until recovery of hematopoiesis, pediatric hematopoietic stem cell transplant (HSCT) patients are dependent on red blood cell and platelet transfusions to avoid the complications associated with anemia and thrombocytopenia, respectively. Despite the fact that these patients are high utilizers of blood components, there are no evidence-based guidelines regarding optimal transfusion practices in this patient population. A web-based survey was designed to examine current transfusion thresholds used by institutions that perform pediatric HSCT. This survey was sent to department directors identified through the Children's Oncology Group directory with a response rate of 69%. The majority of institutions use 8 g/dL as the hemoglobin threshold for red blood cell transfusions (60%), but a significant minority use 7 g/dL (25%). With respect to platelet transfusion thresholds, 47% of respondents report using 20×10/L and 44% use 10×10/L. Respondents were also asked about specific clinical scenarios that would prompt an increase in a patient's threshold. This survey revealed that there is variation in transfusion practices among pediatric HSCT institutions with respect to both baseline transfusion threshold and what prompts an increase in threshold. Future clinical trials are needed to determine optimal transfusion thresholds in pediatric HSCT patients, which can lead to improved standardization in practices.

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“…[6][7][8][9] This survey is unique in revealing both interinstitutional differences and intrainstitutional differences in transfusion thresholds for HSCT versus general oncology patients.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%