The use of bovine serum albumin-glutaraldehyde tissue adhesive (BioGlue ® ) for tumor bed closure following open partial nephrectomy

Bahouth, Zaher; Halachmi, Sarel; Shprits, Sagi; Burbara, Y.; Avitan, Ofir; Masarwa, Ismael; Moskovitz, Boaz; Nativ, Ofer

doi:10.1016/j.acuroe.2017.07.005

Cited by 2 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the natural-based surgical glues, albumin is a globular protein found in blood plasma and is obtained from different animal sources. Various commercialized albumin glues (e.g., BioGlue ® ) have been FDA-approved and are used as hemostats in vascular and cardiac surgeries [12][13][14]. These products are generally composed of glutaraldehyde (GA) and bovine albumin available in a dual-chambered syringe.…”

Section: Introductionmentioning

confidence: 99%

Fermentation-Derived Albumin-Based Hydrogels for Tissue Adhesion Applications

et al. 2023

View full text Add to dashboard Cite

Currently, most of the clinically available surgical glues and sealants lack elasticity, good adhesion and biocompatibility properties. Hydrogels as tissue adhesives have received extensive attention for their tissue-mimicking features. Here, a novel surgical glue hydrogel based on a fermentation-derived human albumin (rAlb) and biocompatible crosslinker for tissue-sealant applications has been developed. In order to reduce the risks of viral transmission diseases and an immune response, Animal-Free Recombinant Human Albumin from the saccharomyces yeast strain was used. A more biocompatible crosslinking agent, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), was used and compared with glutaraldehyde (GA). The design of crosslinked albumin-based adhesive gels was optimized by varying the albumin concentration, the mass ratio between albumin and the crosslinking agent as well as the crosslinker type. Tissue sealants were characterized in terms of mechanical (tensile and shear), adhesive and in vitro biocompatibility properties. The results indicated that the mechanical and adhesive properties improved as the albumin concentration increased and the mass ratio between albumin and crosslinker decreased. Moreover, the EDC-crosslinked albumin gels have better biocompatibility properties than GA-crosslinked glues.

show abstract

Section: Introductionmentioning

confidence: 99%

Fermentation-Derived Albumin-Based Hydrogels for Tissue Adhesion Applications

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Recently, some novel suture methods have included staplers, zips, 2 and tissue adhesives. 3 For example, Chen et al reported that a surgical zipper technique achieved similar incidence of postoperative complications, less time for incision closure, and perfect aesthetic results compared with intracutaneous sutures. 2 Bahouth et al proved that bovine serum albumin–glutaraldehyde tissue adhesive (BioGlue (R) ) for tumor bed closure enabled satisfactory functional outcome and could potentially reduce ischemia time.…”

Section: Introductionmentioning

confidence: 99%

“…2 Bahouth et al proved that bovine serum albumin–glutaraldehyde tissue adhesive (BioGlue (R) ) for tumor bed closure enabled satisfactory functional outcome and could potentially reduce ischemia time. 3 Staplers are used in some medical surgeries. For example, skin staplers are used for skin sutures such as neck or belly wounds, whereas rectal anastomosis staplers are used for gastrointestinal tract sutures.…”

Section: Introductionmentioning

confidence: 99%

In vivo evaluation of bending strengths and degradation rates of different magnesium pin designs for oral stapler

Yuan

Bai

et al. 2020

Journal of Applied Biomaterials & Functional Materials

View full text Add to dashboard Cite

Magnesium alloys have been potential biodegradable implants in the areas of bone, cardiovascular system, gastrointestinal tract, and so on. The purpose of this study is to evaluate Mg–2Zn alloy degradation as a potential suture material. The study included Sprague–Dawley (SD) rats in vivo. In 24 male SD rats, tests in the leg muscle were conducted using traditional surgical incision and insertion of magnesium alloys of different designs into the tissue. The material degradation topography, elemental composition, and strength of the pins were analyzed. This paper explores magnesium pins with different cross-sectional shapes and diameters to establish a suitable pin diameter and shape for use as an oral stapler, which must have a good balance of degradation rate and strength. The results showed there were good bending strengths over different degradation periods in groups with diameters of 0.8 mm and 0.5 mm, and no significantly different bending strength between the groups of triangle and round cross-section shapes with same diameter of 0.3 mm, although the degradation rate still needs to be improved.

show abstract

The use of bovine serum albumin-glutaraldehyde tissue adhesive (BioGlue ® ) for tumor bed closure following open partial nephrectomy

Cited by 2 publications

References 12 publications

Fermentation-Derived Albumin-Based Hydrogels for Tissue Adhesion Applications

Fermentation-Derived Albumin-Based Hydrogels for Tissue Adhesion Applications

In vivo evaluation of bending strengths and degradation rates of different magnesium pin designs for oral stapler

Contact Info

Product

Resources

About