The use of CA125, human epididymis protein 4 (HE4), risk of ovarian malignancy algorithm (ROMA), risk of malignancy index (RMI) and subjective assessment (SA) in preoperative diagnosing of ovarian tumors

Abstract

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Sensitivity and Specificity of Selected Biomarkers and Their Combinations in the Diagnosis of Ovarian Cancer

“…According to the researchers, RMI was better at identifying malignant cases than any other single factor in the diagnosis of OC [35]. The usefulness of CA125, HE4, ROMA, RMI, and subjective assessment (SA) in the preoperative diagnosis of ovarian tumors was compared by Janas Ł et al [36], who obtained AUCs for CA125, HE4, ROMA, RMI, and SA of 0.819, 0.909, 0.911, 0.895, and 0.895, respectively. According to the authors, ultrasound methods are very useful in the diagnosis of ovarian tumors, RMI and SA have a similar overall diagnostic value, while, in their opinion, HE4 and ROMA were the most useful [36].…”

“…The usefulness of CA125, HE4, ROMA, RMI, and subjective assessment (SA) in the preoperative diagnosis of ovarian tumors was compared by Janas Ł et al [36], who obtained AUCs for CA125, HE4, ROMA, RMI, and SA of 0.819, 0.909, 0.911, 0.895, and 0.895, respectively. According to the authors, ultrasound methods are very useful in the diagnosis of ovarian tumors, RMI and SA have a similar overall diagnostic value, while, in their opinion, HE4 and ROMA were the most useful [36]. Van Gorp et al [37] found that RMI was more helpful than the ROMA algorithm in the diagnosis of ovarian tumors.…”

“…Comparison of sensitivity and specificity of algorithms used in the diagnosis of ovarian cancer[6,31,33,35,36,39,40].…”