1988
DOI: 10.1097/00132586-198810000-00050
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The Use of Caffeine in the Control of Post-Anesthetic Apnea in Former Premature Infants

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Cited by 6 publications
(5 citation statements)
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“…Caffeine is usually preferred as it has been proposed to have lesser haemodynamic consequences, a greater therapeutic index and a longer half‐life. Three studies have shown a significant prophylactic effect of intravenous caffeine (31–33) and a Cochrane review concluded that caffeine was effective even although the number of patients was small (3). A dose of 10 mg/kg intravenous caffeine seems to be effective and safe but further dose–response studies are needed to determine the effective dosing regime.…”
Section: Anaesthetic Managementmentioning
confidence: 99%
“…Caffeine is usually preferred as it has been proposed to have lesser haemodynamic consequences, a greater therapeutic index and a longer half‐life. Three studies have shown a significant prophylactic effect of intravenous caffeine (31–33) and a Cochrane review concluded that caffeine was effective even although the number of patients was small (3). A dose of 10 mg/kg intravenous caffeine seems to be effective and safe but further dose–response studies are needed to determine the effective dosing regime.…”
Section: Anaesthetic Managementmentioning
confidence: 99%
“…Administration of 5/10 mg/kg caffeine IV preoperatively significantly reduces postoperative apnoea. [19] Caffeine stimulates the respiratory center and cardiovascular system, enhances responsiveness to CO 2, increases diaphragmatic contractility, minute ventilation oxygen consumption and metabolic rate. [20] A reduction in duration of CPAP has been observed.…”
Section: American Association Of Pediatrics (Aap) Definitionmentioning
confidence: 99%
“…The methylxanthines have been used to treat postoperative apnea for over 20 years (92–95). A systematic review (96) of prophylactic caffeine to prevent postoperative apnea found three good‐quality randomized‐controlled trials enrolling a total of 78 infants born prematurely (92,97,98). The infants were 35–44 weeks PMA and doses of 5–10 mg·kg −1 caffeine base were used.…”
Section: Evidence For the Use Of Caffeine In Anesthesiamentioning
confidence: 99%