The use of cannabinoids in chronic pain

Reynolds, Timothy D.; Osborn, Hannah L.

doi:10.1136/bcr-2013-010417

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…The International Pain Research Society has stated that pain is the fifth vital sign after blood pressure, pulse, respiration, and body temperature. As a long-term symptom, cancer pain has affected patients and their family members in terms of physiology, psychology, spirit, and quality of life (11). Studying the genes associated with PDAC cancer pain will therefore have significant clinical implications and will help to provide a foundation for PDAC patients' pain management.…”

Section: Protein Interaction Network Construction and Module Analysis...mentioning

confidence: 99%

Screening of potential pain genes in pancreatic ductal adenocarcinoma (PDAC) based on bioinformatics methods

Xu¹,

Wang²,

Hu³

et al. 2023

J Gastrointest Oncol

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Background: We aimed to identify cancer pain genes in pancreatic ductal adenocarcinoma (PDAC) using bioinformatic tools to provide evidence for pain treatment in PDAC patients.Methods: The GSE50570 data were obtained from the high-throughput Gene Expression Omnibus (GEO) database and subsequently analyzed. A volcano map, principal component analysis (PCA) map, box plot, and heat map were drawn, and a Venn diagram was constructed by comparison with human secreted histone genes. The differentially expressed secreted histone genes in PDAC were obtained. Then, Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed, followed by protein-protein interaction (PPI) network analysis and key genetic screening.Results: In comparison to normal samples, the expression of 81 secreted protein-related genes was downregulated, and the expression of 12 secreted protein-related genes was upregulated in PDAC.According to the GO and KEGG enrichment analysis results, these differentially expressed genes are mainly involved in the PI3K-Akt signaling pathway, protein digestion and absorption, extracellular matrix (ECM) receptor interaction, AGE-RAGE (advanced glycation endproducts-the Receptor of Advanced Glycation Endproducts) signaling pathway, relaxin signaling pathway, interleukin-17 (IL-17) signaling pathway, and transforming growth factor-β (TGF-β) signaling pathway, affecting the different manifestations of PDAC cancer pain. We used Cytoscape software to construct a protein interaction network of common differentially expressed genes and obtained three clusters with high scores. Our literature review found that several genes, including PTGS2, VCAN, and CCL2, were directly related to cancer pain occurrence.Conclusions: By data mining the PDAC tumor expression, dozens of differentially expressed genes were identified in this study, several of which have been associated with the frequency and severity of cancer pain.This study provides an important foundation for the pain treatment of PDAC tumor patients.

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Section: Protein Interaction Network Construction and Module Analysis...mentioning

confidence: 99%

Screening of potential pain genes in pancreatic ductal adenocarcinoma (PDAC) based on bioinformatics methods

Xu¹,

Wang²,

Hu³

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

show abstract

“…The new study has shown that chronic intake of marijuana can protect critical immune tissue from the damaging effects of HIV infection [30]. At present, AIDS and cancer patients utilize various drugs containing synthetic THC such as Dronabinolor Nabilone [31][32][33]. The drugs are used to decrease marijuana withdrawal symptoms as well as to increase appetite and prevent chemotherapy related nausea and vomiting [28,34,35].…”

Section: Therapeutic Uses Of Marijuanamentioning

confidence: 99%