The use of cardiac troponin T (cTnT) in the postmortem diagnosis of acute myocardial infarction and sudden cardiac death: A systematic review

Biomarkers of myocardial injury in rats after cantharidin poisoning: Application for postmortem diagnosis and estimation of postmortem interval

“…However, in our present study, the postmortem TN-T expression in cardiac blood both in control group and experimental group were stable and regression analysis results revealed no significant relationship between TN-T and PMI. There are multiple possible reasons for discrepant results between previous study and current study, such as the rate of fragmentation of TN-T in different samples, the cause of death, temperature, and so on 13 – 18 , 29 .…”

“…In our present study, the higher expression of TN-T were found in rats died of cantharidin poisoning and TN-T levels were stable in each time interval after death, which suggested TN-T is a potential postmortem biomarker of mycardial injury induced by cantharidin poisoning. Most previous studies focused on the diagnostic role of postmortem TN-T in patients with acute myocardial infarction or sudden cardiac death and found the elevation of TN-T expression may depend on the severity of ischemic myocardial damage 13,14,25 , which was consisted with the result of the current study. Moreover, our data showed that the TN-T levels in postmortem remained stable for up to 168 h after death, which is over the 48 h reported in previous.…”

“…Troponin T (TN-T) is the major biomarker in the clinical diagnosis of acute myocardial injury 12 , the use of TN-T in the postmortem diagnosis of acute myocardial infarction and sudden cardiac death have been proved by some previous studies 13,14 . Previous findings suggest that cardiac troponins are specific markers of myocardial damage and elevated postmortem blood TN-T levels may be indicative of the severity of myocardial damage from various causes of death at the time of death 15 .…”

“…What is more, many previous studies have evaluated the potential forensic use of TN-T to determine the PMI in deaths of different causes 16 . However, the sensitivity and specialty of TN-T in the postmortem diagnosis of myocardial injury and the relationship between TN-T and PMI estimation are controversial [13][14][15][16][17][18] . So that it is necessary to verify whether the TN-T can be used for the postmortem diagnosis of cantharidin-induced myocardial injury and explore possible serum biomarkers which can be used for postmortem diagnosis and PMI estimation.…”

Biochemical Markers of Sudden Cardiac Death

“…The use of frozen samples for biochemical post-mortem analysis should be avoided because freezing can cause severe hemolysis and can also affect the concentration of biochemical markers in different biological specimens. Barberi and van den Hondel [23] suggested that the bodies should be refrigerated, as this can delay the autolysis of the body and at the same time it can reduce the degree of hemolysis.…”