The Use of Celecoxib and Dexamethasone for the Prevention and Control of Postoperative Pain After Periodontal Surgery

Abstract

The findings of this study suggest that the preemptive and postoperative use of celecoxib or dexamethasone were effective in the management of postoperative pain following open-flap debridement.

Effect of Pretreatment Prednisolone on Postendodontic Pain: A Double-blind Parallel-randomized Clinical Trial

“…Traditionally, impacted third molar extractions and periodontal surgery have served as excellent models for testing analgesic and anti-inflammatory drugs (19,20,22). The dental literature presents few studies evaluating oral administration of glucocorticoids for the prevention and control of postendodontic pain (1,14,(24)(25)(26) and no evaluations with oral prednisolone.…”

“…This is the first study to use a preoperative, single oral dose of prednisolone for the control and prevention of postendodontic pain. Oral administration was preferred because this technique is clinically effective and convenient; the use of intramuscular or intravenous injection might lead to discomfort and fear and is not well-accepted by some patients (1,14,19,24). Most patients and dentists would prefer to provide an anti-inflammatory agent immediately before or selfadministered as needed by the patient after anesthesia has worn off.…”

“…The maximum benefit of the anti-inflammatory is obtained when therapeutic levels are reached before tissue manipulation (1,4,10,11,16,(18)(19)(20).…”

Preemptive and Postoperative Medication Protocols for Root Coverage Combined with Connective Tissue Graft

“…Thus, preemptive antiinflammatory drugs may prevent hyperalgesia, reducing postoperative pain and discomfort and the consumption of analgesics. In mucoperiosteal flap surgery for scaling and root planing (17) and in crown lengthening (18), no significant differences for the intensity of pain were demonstrated when both anti-inflammatories (SAID and NSAID) were compared as preemptive and postoperative medications. Steffens et al (25) also showed no significant difference for pain between the SAID (8 mg dexamethasone) and NSAID (120 mg etoricoxib) Groups; this was also true for mucoperiosteal flap surgery for scaling and root planing, but the medications were administered only in the preemptive period.…”

“…For all of these evaluated aspects, no differences were observed between the SAID and NSAID groups, confirming the homogeneity of experimental groups and supporting the outcomes obtained in the study. These assessments were not carried out in other studies (16,17,(25)(26)(27)30), which could affect the interpretation of individual morbidity data.…”