The Use of Ceramics as Bone Substitutes in Revision Hip Arthroplasty

Whitehouse, Michael R; Blom, Ashley W

doi:10.3390/ma2041895

Cited by 12 publications

(6 citation statements)

References 81 publications

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“…Nevertheless, to overcome the limitations of these treatments, especially those related to the lack of availability of patient/donor tissue, synthetic or semi-synthetic materials have been demonstrated to be valid alternatives for the replacement of natural bone stock [ 16 , 17 , 18 , 19 , 20 , 21 ]. Among these, absorbable ceramics such as hydroxyapatite (HA), calcium sulphate, and tricalcium sulphate (TCP), or their combination, are commonly used as bone grafts [ 22 ]. Notably, HA is a major component of natural bone and can favour new bone formation while acting as a scaffold in the implanted site.…”

Section: Introductionmentioning

confidence: 99%

An Observational Prospective Clinical Study for the Evaluation of a Collagen-Hydroxyapatite Composite Scaffold in Hip Revision Surgery

Cimatti

Andreoli

Busacca³

et al. 2022

JCM

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One of the greatest challenges of hip revision surgery is the need to restore extensive bone loss by creating a stable reconstruction with long-term durability. The present observational, investigator-initiated prospective study was carried out to evaluate the clinical and radiological results of the use of a commercial biomimetic collagen–hydroxyapatite composite biomaterial (RegenOss) applied in hip revision surgery. Thirty-three patients who underwent hip revision were included in this study, and 29 received up to 2 years of follow-up. The acetabulum was reconstructed using an uncemented hemispherical shell both with or without an iliac fixation stem. Functional recovery was assessed according to the Harris Hip Score (HHS) at the pre-hospitalisation check-up, and at 6-, 12-, and 24-month follow-ups. Radiological evaluation consisting of X-ray analyses (6, 12, and 24 month follow-ups) and CT scan exams (within 10 weeks post-surgery and at 12-month follow-up) were performed to evaluate the reduction in bone defect and new bone regeneration. All the patients reported a complete recovery and a considerable improvement in functional outcome assessed by the HHS, which was significantly higher at all the follow-ups than at pre-hospitalisation. Moreover, radiological assessments revealed good scaffold integration. Overall, collected data suggest that RegenOss is a valid and safe alternative to restoring acetabular bone loss in revision hip arthroplasty.

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Section: Introductionmentioning

confidence: 99%

An Observational Prospective Clinical Study for the Evaluation of a Collagen-Hydroxyapatite Composite Scaffold in Hip Revision Surgery

Cimatti

Andreoli

Busacca³

et al. 2022

JCM

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“…32,33 It seems that the inorganic phosphate was not removed during purification. As a result, there was an increase in the similarity to the mineral components of natural bones, 34 which will be advantageous for its use as a bone graft material.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…It has been reported that calcium ions are concentrated in coccolithophore cells and that coccolith production is regulated by phosphate availability. , It seems that the inorganic phosphate was not removed during purification. As a result, there was an increase in the similarity to the mineral components of natural bones, which will be advantageous for its use as a bone graft material.…”

Section: Resultsmentioning

confidence: 99%

Bone Graft Biomineral Complex Coderived from Marine Biocalcification and Biosilicification

Yun

Jeong

Nam

et al. 2021

ACS Appl. Bio Mater.

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Bone graft materials have been mainly developed based on inorganic materials, including calcium phosphate. However, these graft materials usually act as osteoconductive rather than osteoinductive scaffolds. To improve bone reconstruction, a combination of several materials has been proposed. However, there are still no alternatives that can completely replace the existing animal-derived bone graft materials. In this work, a marine-inspired biomineral complex was suggested as a potential bone graft material. The proposed biosilicified coccolithophorederived coccoliths using bioengineered mussel adhesive proteins show osteopromotive ability through the synergistic effects of osteoconductivity from calcium carbonate and osteoinductivity from silica. Its possibility of use as a bone substitute was determined by evaluating the in vitro osteogenic behaviors of multipotent mesenchymal stem cells and in vivo bone regeneration in a rat calvarial defect model. Therefore, the marine-inspired biomineral complex developed in this study could be successfully used for bone tissue engineering.

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“…No risk of transmitting disease plus immunogenicity after implantation are the major advantages of the ceramics [31]. Other remarkable advantages are higher resistance to compressive force, low toxicity, good corrosion resistance, and promotion of the formation of new hard tissues.…”

Section: Ceramicsmentioning

confidence: 99%

Recent Advancements in Materials and Coatings for Biomedical Implants

Kirubaharan

Chandrasekar

Dasan

et al. 2022

Gels

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Metallic materials such as stainless steel (SS), titanium (Ti), magnesium (Mg) alloys, and cobalt-chromium (Co-Cr) alloys are widely used as biomaterials for implant applications. Metallic implants sometimes fail in surgeries due to inadequate biocompatibility, faster degradation rate (Mg-based alloys), inflammatory response, infections, inertness (SS, Ti, and Co-Cr alloys), lower corrosion resistance, elastic modulus mismatch, excessive wear, and shielding stress. Therefore, to address this problem, it is necessary to develop a method to improve the biofunctionalization of metallic implant surfaces by changing the materials’ surface and morphology without altering the mechanical properties of metallic implants. Among various methods, surface modification on metallic surfaces by applying coatings is an effective way to improve implant material performance. In this review, we discuss the recent developments in ceramics, polymers, and metallic materials used for implant applications. Their biocompatibility is also discussed. The recent trends in coatings for biomedical implants, applications, and their future directions were also discussed in detail.

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The Use of Ceramics as Bone Substitutes in Revision Hip Arthroplasty

Cited by 12 publications

References 81 publications

An Observational Prospective Clinical Study for the Evaluation of a Collagen-Hydroxyapatite Composite Scaffold in Hip Revision Surgery

An Observational Prospective Clinical Study for the Evaluation of a Collagen-Hydroxyapatite Composite Scaffold in Hip Revision Surgery

Bone Graft Biomineral Complex Coderived from Marine Biocalcification and Biosilicification

Recent Advancements in Materials and Coatings for Biomedical Implants

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