The use of chitosan-6-mercaptonicotinic acid nanoparticles for oral peptide drug delivery

Millotti, Gioconda; Perera, Glen; Vigl, Claudia; Pickl, Karin E.; Sinner, Frank; Bernkop‐Schnürch, Andreas

doi:10.3109/10717544.2010.522611

Cited by 34 publications

(17 citation statements)

References 31 publications

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“…Anitha et al (2012) used the curcumin-loaded N,O-carboxymethyl chitosan nanoparticles to deliver cancer drug. Millotti et al (2011) used chitosan-6-mercaptonicotinic acid nanoparticles to deliver oral peptide. Xing (2013) prepared the folate modified-chitosan nanoparticles for new tumor-targeting drug delivery.…”

Section: Chitosans and Its Derivatives As Vehicles To Deliver Chemicamentioning

confidence: 99%

Chitosan and its derivatives as vehicles for drug delivery

2017

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Chitosan and its derivatives as vehicles for drug delivery can achieve the purpose of sustained release and controlled release for drugs, improve the stability of drugs, and reduce adverse drug reactions. So, the bioavailability of drugs can be enhanced. Therefore, chitosan and its derivatives have become a hotspot in the field of drug delivery. Their characteristics as drug delivery vectors were introduced, the types and applications were summarized. The development direction of chitosan and its derivatives in this field was also forecasted.

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Section: Chitosans and Its Derivatives As Vehicles To Deliver Chemicamentioning

confidence: 99%

Chitosan and its derivatives as vehicles for drug delivery

2017

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“…In fact, mucoadhesive systems for oral drug administration have raised widespread interest, thanks to their recognized potential to improve the oral bioavailability of drugs having a poor mucosal permeability. [3][4][5][6] Indeed, mucoadhesion may slow down the transit of the therapeutic system down the gastrointestinal (GI) tract, thus prolonging drug contact with the absorption site and favoring the formation of high concentration gradients. 7 In addition, the use of mucoadhesive nanoparticle (NP) drug systems would allow the chemical stability of active principles in the GI environment to be improved.…”

Section: Introductionmentioning

confidence: 99%

Methyl-β-cyclodextrin quaternary ammonium chitosan conjugate: nanoparticles vs macromolecular soluble complex

Piras

Fabiano

Chiellini

et al. 2018

IJN

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PurposeThe present study aimed to compare a novel cyclodextrin–polymer–drug complex in solution with a dispersed supramolecular nanosize system, made of the same complex, for ability to carry dexamethasone (DEX) across excised rat intestine.ResultsMethyl-β-cyclodextrin-quaternary ammonium chitosan conjugate (QA-Ch-MCD) was obtained by covalent grafting through a 10-atom spacer. The conjugate was characterized by 1H-NMR, resulting in 24.4% w/w of MCD content. Phase solubility profile analysis of the QA-Ch-MCD/DEX complex yielded an association constant of 14037 M−1, vs 4428 M−1 for the plain MCD/DEX complex. Nanoparticle (NP) dispersions resulted from ionotropic gelation of the QA-Ch-MCD/DEX complex by sodium tripolyphosphate, leading to 9.9%±1.4% drug loading efficiency. The mean diameter and zeta potential for NP were 299±32 nm (polydispersity index [PI] 0.049) and 11.5±1.1 mV, respectively. Those for QA-Ch-MCD/DEX were 2.7±0.4 nm (PI 0.048) and 6.7±0.6 mV. QA-Ch-MCD/DEX solutions and corresponding NP dispersions were compared in vitro for water-assisted transport through mucus, DEX permeation through excised rat intestine, and ex vivo mucoadhesivity. The complex showed higher mucoadhesion and lower transport rate through mucus; also, it provided faster drug permeation across excised rat intestine.ConclusionCarrier adhesion to mucus surface has played a most important role in favoring transepithelial permeation. Then, within the concerns of the present study, the use of NP seems not to provide any determinant advantage over using the simpler macromolecular complex.

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“…It is used to coat surface of liposomes for improving bioavailability of poorly absorbed oral drugs thus increasing their mucoadhesiveness and enhancing their contact time with intestinal mucosa [43]. Thiolated derivatives of chitosan have been used for oral peptide delivery thus providing more conformational stability to these peptides [44]. Chitosan has been used to formulate microparticles for pulmonary delivery of active medicaments.…”

Section: Applications Of Chitosan In Drug Deliverymentioning

confidence: 99%

Surface-Modified Solid Lipid Nanoparticulate Formulation for Ifosfamide: Development and Characterization

Pandit

Dash²

2011

Nanomedicine

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The use of chitosan-6-mercaptonicotinic acid nanoparticles for oral peptide drug delivery

Cited by 34 publications

References 31 publications

Chitosan and its derivatives as vehicles for drug delivery

Chitosan and its derivatives as vehicles for drug delivery

Methyl-β-cyclodextrin quaternary ammonium chitosan conjugate: nanoparticles vs macromolecular soluble complex

Surface-Modified Solid Lipid Nanoparticulate Formulation for Ifosfamide: Development and Characterization

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The use of chitosan-6-mercaptonicotinic acid nanoparticles for oral peptide drug delivery

Cited by 34 publications

References 31 publications

Chitosan and its derivatives as vehicles for drug delivery

Chitosan and its derivatives as vehicles for drug delivery

Methyl-&beta;-cyclodextrin quaternary ammonium chitosan conjugate: nanoparticles vs macromolecular soluble complex

Surface-Modified Solid Lipid Nanoparticulate Formulation for Ifosfamide: Development and Characterization

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Methyl-β-cyclodextrin quaternary ammonium chitosan conjugate: nanoparticles vs macromolecular soluble complex