2007
DOI: 10.1002/chir.20459
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The use of circular dichroism spectroscopy for studying the chiral molecular self‐assembly: An overview

Abstract: Self-assembly plays an important role in the formation of many chiral biological structures and in the preparation of chiral functional materials. Therefore the control of chirality in synthetic or biological self-assembled systems is important either for the comprehension of recognition phenomena or to obtain materials with predictable and controllable properties. Circular dichroism was developed to study molecular chirality, however, because of its outstanding sensitivity to chiral perturbations of the syste… Show more

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Cited by 207 publications
(169 citation statements)
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“…[30][31][32][33][34] Moreover, ECCD is broadly appreciated as invaluable, highly sensitive and selective method to study conformational changes, self-assembly and ligand binding of proteins, DNA, RNA and complex synthetic architectures. [30][31][32][33][34] In contrast to this frequent use in structural studies, ECCD is rarely used to study functions. This is surprising because advantages known from structural studies, such as high sensitivity without interference from achiral components of complex systems or the ratiometric detection of the bisignate ECCD Cotton effect to exclude artifacts, apply for functional studies in complex systems as well.…”
Section: Introductionmentioning
confidence: 99%
“…[30][31][32][33][34] Moreover, ECCD is broadly appreciated as invaluable, highly sensitive and selective method to study conformational changes, self-assembly and ligand binding of proteins, DNA, RNA and complex synthetic architectures. [30][31][32][33][34] In contrast to this frequent use in structural studies, ECCD is rarely used to study functions. This is surprising because advantages known from structural studies, such as high sensitivity without interference from achiral components of complex systems or the ratiometric detection of the bisignate ECCD Cotton effect to exclude artifacts, apply for functional studies in complex systems as well.…”
Section: Introductionmentioning
confidence: 99%
“…8,9 Because of its high sensitivity, this spectroscopic technique has been widely practiced to monitor the formation of helical superstructures and the formation of gels through self-assembly processes. 10 A number of useful correlations, rules, or procedures for relating the signs of the measured optical activity and absolute configuration have been established for a variety of structural motifs. Meanwhile, all such empirical methods suffer from exceptions that in some cases were preceded by incorrect assignments.…”
Section: Introductionmentioning
confidence: 99%
“…Other classical topics that are routinely addressed by CD spectroscopy include conformational changes, self-assembly, and ligand binding of proteins, DNA, RNA, and complex synthetic architectures. [1][2][3] In sharp contrast to this popular use to study structures, CD spectroscopy is rarely used to study functions. There are no obvious reasons for this neglect.…”
Section: Introductionmentioning
confidence: 98%