The Use of Citrate Solutions in the Prevention of Peritoneal Adhesions

Pope, Saxton T.

doi:10.1097/00000658-191401000-00008

Cited by 8 publications

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“…It was shown in a paper from 1913 that the use of sodium citrate 2% and sodium chloride 4% in water helped prevent adhesions. 52 The question is raised regarding attempts in preventing adhesions with adjuvants and whether they prevent or encourage a natural protective process?…”

Section: Lack Of Haptics Causes Hypoxiamentioning

confidence: 99%

Laparoscopy and Adhesion Formation, Adhesions and Laparoscopy

Ott

2008

Semin Reprod Med

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Laparoscopic peritoneal adhesion formation follows a pathway similar to laparotomy, both of which are only partially understood. Laparoscopic adhesion formation is complicated and influenced by pressure, dry gas desiccation, and hypoxia caused and superimposed by the pneumoperitoneum. It may further be affected by products of tissue combustion and inappropriate irrigation. Adjuvants are a poor substitute for attention to surgical detail and offer little help for the problem. The best defenses to reduce adhesion formation are maintenance of a normal physiologic peritoneal state that is wet and warm, gentle tissue handling, low intra-abdominal pressure, appropriate irrigation, and evacuation of smoke. Continued research into peritoneal cell response to the provocative circumstances of laparoscopic surgery will hopefully offer assistance to diminish the potential for laparoscopic adhesion formation.

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Section: Lack Of Haptics Causes Hypoxiamentioning

confidence: 99%

Laparoscopy and Adhesion Formation, Adhesions and Laparoscopy

Ott

2008

Semin Reprod Med

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“…Other pharmacological agents have drawn less attention and might deserve further study 9 , 10 . Hypertonic glucose has fibrinolytic action in vitro , so it could have value if used intraperitoneally to facilitate abdominal drainage in dialysis patients 10 , 11 . Animal experiments to evaluate the value of hypertonic glucose in the prevention of adhesions have been inconclusive 12 .…”

Section: Introductionmentioning

confidence: 99%

Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats

et al. 2021

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Purpose To evaluate the efficacy of hypertonic glucose (10%), alone or in combination with the corticoid dexamethasone, to prevent peritoneal adhesion following hysterectomy in rats. Methods Forty-two adult rats underwent hysterectomy with peritoneal lavage: G1 – glucose (10%); G2 – glucose (10%) and dexamethasone 3 mg·kg –1 ; and G3 – physiological saline (PS) 0.9%. Results In the macroscopic analysis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001), G3 compared to G1 and G2. There was no difference between groups after 28 days. In the microscopic analysis, the median vascular proliferation after 14 days was 2 for G1, 1 for G2, and 3 for G3 (p = 0.0037, G3 vs. G1 and G2). After 28 days, G1 showed a median vascular proliferation score of 2, G2 of 2.5, and G3 of 3 (p < 0.0001, G3 vs. G1 and G2). Regarding the inflammatory reaction after 14 days, G1 had a median score of 2, G2 of 1, and G3 of 3 (p = 0.7916). After 28 days, G1 had a median score of 0.5 (0–1.75), G2 of 1.5, and G3 of 2.5 (p < 0.0001, G3 vs. the others and G2 vs. G1). In the evaluation of fibrosis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001, G3 vs. G1and G2). After 28 days, G1 had a median fibrosis score of 1, G2: 2, and G3: 2.5 (p < 0.0001), G3 vs. the others andG2 vs. G1). Conclusions The use of hypertonic glucose (10%) solution seems to reduce macroscopic and microscopic pelvic adhesions.

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Systemic Administration of Heparin and Dicumarol® for Postoperative Adhesions

Davidson¹

1949

Arch Surg

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The Use of Citrate Solutions in the Prevention of Peritoneal Adhesions

Cited by 8 publications

References 0 publications

Laparoscopy and Adhesion Formation, Adhesions and Laparoscopy

Laparoscopy and Adhesion Formation, Adhesions and Laparoscopy

Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats

Systemic Administration of Heparin and Dicumarol® for Postoperative Adhesions

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