The Use of Combination Vaccines Has Improved Timeliness of Vaccination in Children

Kalies, Helen; Grote, Veit; Verstraeten, Thomas; Hessel, Luc; Schmitt, Heinz-Josef; Kries, Rüdiger von

doi:10.1097/01.inf.0000222413.47344.23

Cited by 150 publications

(77 citation statements)

References 7 publications

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“…Furthermore, combination vaccines may reduce the logistical costs of vaccine delivery, at the same time increasing compliance with vaccination programs leading to more timely vaccination and greater vaccine coverage. [12][13][14] GlaxoSmithKline (GSK) Biologicals licensed the first diphtheria-tetanus-whole cell pertussis-hepatitis B (DTPw-HBV) combination vaccine (Tritanrix TM -HepB) in 1996. 15 Originally formulated with thiomersal, a mercury-based compound widely used preservative in many vaccines, GSK Biologicals developed a DTPw-HBV formulation with reduced preservative content (DTPw-HBV LT ).…”

Section: Resultsmentioning

confidence: 99%

Immunogenicity, reactogenicity and safety of three-dose primary and booster vaccination with combined diphtheria-tetanus-whole-cell pertussis-hepatitis B-reduced antigen contentHaemophilus influenzaetype b vaccine in Filipino children

Gatchalian¹,

Ramakrishnan²,

Bock³

et al. 2010

Human Vaccines

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Section: Resultsmentioning

confidence: 99%

Immunogenicity, reactogenicity and safety of three-dose primary and booster vaccination with combined diphtheria-tetanus-whole-cell pertussis-hepatitis B-reduced antigen contentHaemophilus influenzaetype b vaccine in Filipino children

Gatchalian¹,

Ramakrishnan²,

Bock³

et al. 2010

Human Vaccines

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“…The use of combined vaccines has potential benefits, including reduced number of patient visits, fewer complications associated with multiple injections, decreased stocking and visit costs, and lowering the risk of delayed or missed vaccinations. 30,31 Although PCVs (regardless serotype number) were included in the NIP in 2006 with a 3 C 1 schedule, vaccination with 3 doses exceeded 95% in the total study population. The time of implementation in the NIP and the fact that full reimbursement was granted in 2008, so not enabling all children to complete 4 doses, makes comparison with 2012 rates impossible.…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional vaccination coverage study in preschool children attending nurseries-kindergartens: Implications on economic crisis effect

Georgakopoulou

Menegas

Katsioulis

et al. 2017

Human Vaccines & Immunotherapeutics

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Vaccination coverage studies are important in determining a population's vaccination status and strategically adjusting national immunization programs. This study assessed full and timely vaccination coverage of preschool children aged 2-3 y attending nurseries-kindergartens (N-K) nationwide at the socioeconomic crisis onset. Geographically stratified cluster sampling was implemented considering prefectures as strata and N-K as clusters. The N-K were selected by simple random sampling from the sampling frame while their number was proportional to the stratum size. In total, 185 N-K (response rate 93.9%) and 2539 children (response rate 81.5%) participated. Coverage with traditional vaccines for diphtheria-tetanus-pertussis, polio and measles-mumps-rubella was very high (>95%), followed by Haemophilus influenzae type b and varicella vaccines. Despite very high final coverage, delayed vaccination was observed for hepatitis B (48.3% completed by 12 months). Significant delay was observed for the booster dose of pneumococcal conjugate vaccines (PCV) and meningococcal C conjugate vaccines (MCC). Of the total population studied, 82.3% received 3 PCV doses by 12 months, while 62.3% received the fourth dose by 24 months and 76.2% by 30 months. However, 89.6% received at least one MCC dose over 12 months. Timely vaccinated for hepatitis A with 2 doses by 24 months were 6.1%. Coverage was significantly low for Rotavirus (<20%) and influenza (23.1% one dose). High vaccination coverage is maintained for most vaccines at the beginning of the crisis in Greece. Coverage and timeliness show an increasing trend compared to previous studies. Sustained efforts are needed to support the preventive medicine system as socioeconomic instability continues.

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“…However, the introduction of IPV into the Korean vaccination schedule increased the number of injections given to children at those vaccination visits when poliomyelitis vaccine was required. Data from the United States and Germany suggest that both the timeliness of vaccination and coverage rates until 24 months of age are improved when children receive combination vaccines compared to separate vaccines that require additional injections 12,13) . .…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity, Reactogenicity and Safety of a Combined DTPa-IPV Vaccine Compared with Separate DTPa and IPV Vaccines in Healthy Korean Infants

Kim

Ho²,

Shin

et al. 2010

Korean J Pediatr Infect Dis

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∫∫ , Wavre, BelgiumPurpose : To compare immunogenicity and reactogenicity of a combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine (DTPa-IPV, Infanrix TM IPV, GlaxoSmithKline Biologicals) with co-administration of commercially available DTPa and IPV vaccines at separate injection sites (DTPa+IPV). Methods : A total of 458 infants aged 8-12 weeks were randomized to receive three-dose primary vaccination at 2, 4 and 6 months with DTPa-IPV or DTPa+IPV. Blood samples were collected pre and post vaccination for measurement of immune responses. Reactogenicity was assessed following each dose using diary cards. Results : One month post-dose 3, seroprotection rates for anti-diphtheria, anti-tetanus and anti-poliovirus types 1, 2 and 3 were 99.5% and vaccine response rates to pertussis antigens were at least 98.6% in both DTPa-IPV and DTPa + IPV ≥ groups. Non-inferiority between the groups was demonstrated based on pre-defined statistical criteria. Incidences of both local and systemic symptoms were within the same range across both groups with grade 3 symptoms reported following no more than 4.3% of DTPa-IPV doses and 4.5% of DTPa + IPV doses. Two serious adverse events (both pyrexia) after DTPa-IPV administration were considered vaccine-related. Both infants recovered fully. Conclusion : Combined DTPa-IPV vaccine was immunogenic and well tolerated when used as a three-dose primary vaccination course in Korean infants. DTPa-IPV could be incorporated into the Korean vaccination schedule, reducing the number of injections required to complete primary immunization. (Korean J Pediatr Infect Dis 2010;17:156-168)

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The Use of Combination Vaccines Has Improved Timeliness of Vaccination in Children

Abstract: Combination vaccines are usually advocated for reducing the number of injections. In Germany, however, the use of combination vaccines has also significantly improved timeliness of immunizations.

Cited by 150 publications

References 7 publications

Immunogenicity, reactogenicity and safety of three-dose primary and booster vaccination with combined diphtheria-tetanus-whole-cell pertussis-hepatitis B-reduced antigen contentHaemophilus influenzaetype b vaccine in Filipino children

Immunogenicity, reactogenicity and safety of three-dose primary and booster vaccination with combined diphtheria-tetanus-whole-cell pertussis-hepatitis B-reduced antigen contentHaemophilus influenzaetype b vaccine in Filipino children

A cross-sectional vaccination coverage study in preschool children attending nurseries-kindergartens: Implications on economic crisis effect

Immunogenicity, Reactogenicity and Safety of a Combined DTPa-IPV Vaccine Compared with Separate DTPa and IPV Vaccines in Healthy Korean Infants

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