The use of complementary and alternative medicine in patients with multiple sclerosis: A longitudinal study

Kochs, Luise; Wegener, Sophia; Sühnel, Annett; Voigt, Katharina; Zettl, Uwe K.

doi:10.1016/j.ctim.2013.11.006

Cited by 24 publications

(17 citation statements)

References 18 publications

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“…The majority of the participants in the studies which reported higher complementary and alternative therapies usage had relapsing remitting multiple sclerosis and were mildly or moderately affected. In addition, a study in Germany found that the majority of complementary and alternative therapies use by people with multiple sclerosis happens in the early stages of the disease as initially they explore all avenues (Kochs et al, 2014). As the participants in this sample had a mean time since diagnosis of 16 years this may explain why complementary and alternative therapies use was lower that most of previous research where, when reported, time since diagnosis was from seven to nine years (Apel et al, 2006;Gedizlioglu et al, 2015).…”

Section: Discussionmentioning

confidence: 69%

Access, delivery and perceived efficacy of physiotherapy and use of complementary and alternative therapies by people with progressive multiple sclerosis in the United Kingdom: An online survey

Campbell

Coulter

Mattison

et al. 2017

Multiple Sclerosis and Related Disorders

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Section: Discussionmentioning

confidence: 69%

Access, delivery and perceived efficacy of physiotherapy and use of complementary and alternative therapies by people with progressive multiple sclerosis in the United Kingdom: An online survey

Campbell

Coulter

Mattison

et al. 2017

Multiple Sclerosis and Related Disorders

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“…Traditional Chinese medicine (TCM) in treatment for MS gives promising results [17, 18]. In addition to the previous studies, we found that BSYSC had a good effect in the treatment of MS [19, 20].…”

Section: Introductionmentioning

confidence: 71%

Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis

Fang

Wang

Zheng

et al. 2017

BMC Complement Altern Med

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BackgroundAxon growth inhibitory factors NogoA/Nogo receptor (NgR) and its signaling pathways RhoA/Rho kinase (ROCK) play a critical role in the repair of nerve damage in multiple sclerosis (MS). Bu Shen Yi Sui Capsule (BSYSC) is an effective Chinese formula utilized to treat MS in clinical setting and noted for its potent neuroprotective effects. In this study, we focus on the effects of BSYSC on promoting nerve repair and the underlying mechanisms in mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS.MethodsThe EAE mouse model was induced by injecting subcutaneously with myelin oligodendrocyte glycoprotein (MOG) 35–55 supplemented with pertussis toxin. BSYSC was orally administrated at dose of 3.0 g/kg once a day for 40 days. The levels of protein gene product (PGP) 9.5, p-Tau, growth associated protein (GAP) -43, KI67 and Nestin in the brain or spinal cord on 20 and 40 day post-induction (dpi) were detected via immunofluorescence and Western blot analysis. Furthermore, NogoA/NgR and RhoA/ROCK signaling molecules were studied by qRT-PCR and Western blot analysis.ResultsTwenty or 40 days of treatment with BSYSC increased markedly PGP9.5 and GAP-43 levels, reduced p-Tau in the brain or spinal cord of mice with EAE. In addition, BSYSC elevated significantly the expression of KI67 and Nestin in the spinal cord 40 dpi. Further study showed that the activation of NogoA/NgR and RhoA/ROCK were suppressed by the presence of BSYSC.ConclusionsBSYSC could attenuate axonal injury and promote repair of axonal damage in EAE mice in part through the down-regulation of NogoA/NgR and RhoA/ROCK signaling pathways.

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“…CAM use is wide spread among patients with MS; 57% to 81 % of patients use CAM at some point during the course of their disease [3,5,7,[17][18][19]. An internet search for information using the search words "CAM and MS" rendered 689 000 hits, indicating a vast interest.…”

Section: Multiple Sclerosis and Cammentioning

confidence: 99%

Complementary and Alternative Treatment of Multiple Sclerosis - A Study of Three Cases

Mark¹,

Arman²

2018

obm icm

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Background: People suffering from multiple sclerosis (MS) commonly use complementary and alternative medicine due to the partial efficacy of conventional treatments, the chronic aspect of MS, the impact of pain and the side-effects of medication. An exploratory descriptive study of three cases was performed to document and analyse the experience patients treated for MS with applied kinesiology. Methods: Qualitative interviews were conducted with three patients who had been diagnosed with MS at the Neurology Department and who had sought concurrent applied kinesiological treatment from a kinesiologist. The interviews were open-ended and semistructured. A second interview was conducted for validation. The interviews produced texts that were subjected to phenomenological-hermeneutic text analysis. The three case studies were synthesized for a cross-case analysis. Results: The following themes emerged from the interviews: "having hope", "trusting the kinesiologist", "diet changes essential", "losing trust in the healthcare system", "feeling confused" and "getting better". Patients who underwent applied kinesiology treatment reported a sense of hope, trust and increased health. Comprehensive analysis of the survey results revealed that the patients felt able to "make changes for life", "get past their kinesiology treatment. Conclusion: The interviews provide phenomenological-hermeneutic narratives of health well-being among patients treated with applied kinesiology for MS. The treatment assisted the patients in achieving a sense of well-being and health rather than invalidity. In parallel, the patients exhibited stabilization of their magnetic resonance imaging results during the applied kinesiology treatment period. The patients also reported a feeling that they could transcend their diagnosis of MS.

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The use of complementary and alternative medicine in patients with multiple sclerosis: A longitudinal study

Cited by 24 publications

References 18 publications

Access, delivery and perceived efficacy of physiotherapy and use of complementary and alternative therapies by people with progressive multiple sclerosis in the United Kingdom: An online survey

Access, delivery and perceived efficacy of physiotherapy and use of complementary and alternative therapies by people with progressive multiple sclerosis in the United Kingdom: An online survey

Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis

Complementary and Alternative Treatment of Multiple Sclerosis - A Study of Three Cases

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