The use of contaminated donor organs in transplantation

Zibari, Gazi B.; Lipka, Joy; Zizzi, H; Abreo, Kenneth; Jacobbi, Louise M.; McDonald, John C.

doi:10.1034/j.1399-0012.2000.14040702.x

Cited by 54 publications

(39 citation statements)

References 6 publications

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“…19 Mattner et al 18 showed that 3.9% (11/282) of the recipients developed postoperative infections with the same bacterial or fungal species that had grown in cultures of donor organs. Of these 11 species, six pairs were available for genotyping studies, and only one pair was proven to have the same genetic identity.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the presence of microorganisms in solid-organ preservation solution

Mattana

Marra

Machado³

et al. 2011

Braz J Infect Dis

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Objective: To assess the presence of microorganism contamination in the preservation solution for transplant organs (kidney/pancreas). Method: Between August 2007 and March 2008, 136 samples of preservation solution were studied prior to graft implantation. Variables related to the donor and to the presence of microorganisms in the preservation solution of organs were evaluated, after which the contamination was evaluated in relation to the "recipient culture" variable. Univariate and multivariate statistical analyses were performed. Results: The contamination rate of the preservation solution was 27.9%. Coagulase-negative Staphylococcus was the most frequently isolated microorganism. However, highly virulent agents, such as fungi and enterobacteria, were also isolated. In univariate analysis, the variable "donor antibiotic use" was significantly associated to the contamination of the preservation solution. On the other hand, multivariate analysis found statistical significance in "donor antibiotic use" and "donor's infectious complications" variables. Conclusions: In this study, 27.9% of the preservation solutions of transplant organs were contaminated. Infectious diseases and non-use of antibiotics by the donor were significantly related to the presence of microorganisms in organ preservation solutions. Contamination in organ preservation solutions was not associated with infection in the recipient.

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Section: Methodsmentioning

confidence: 99%

Evaluation of the presence of microorganisms in solid-organ preservation solution

Mattana

Marra

Machado³

et al. 2011

Braz J Infect Dis

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“…Other larger series of donors with fungal infections have not documented infection or graft sequellae in recipients of these livers. 10,11 Aspergillus transmission from a liver recipient who became a cadaveric kidney and heart donor has been reported. Both renal recipients lost their grafts to infection, and the heart recipient developed fungal endocarditis, opthalmitits, and dermatitis but survived.…”

Section: Donors With Fungal Infectionsmentioning

confidence: 99%

“…Another study of bacteremic donors from the Louisiana Organ Procurement Agency found only 3 (8%) of 36 organ recipients had infections caused by organisms found in contaminated donor organs, and only one of nine liver transplant recipients had the same organism isolated from the blood as that recovered from the donor. 11 Bacterial meningitis does not appear to be a contraindication to organ donation provided that the donor and recipients have been adequately treated with antibiotic therapy. Several studies have addressed the use of livers from donors with bacterial meningitis.…”

Section: Donors With Bacterial Infectionsmentioning

confidence: 99%

Impact of donor infections on outcome of orthotopic liver transplantation

Angelis

Cooper

Freeman

2003

Liver Transplantation

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Infection occurs when microbial agents enter the host, either through airborne transmission or by direct contact of a substance carrying the infectious agent with the host. Human body fluids, solid organs, or other tissues often are ideal vectors to support microbial agents and can transmit infections efficiently from donor to recipient. In the case of blood transfusion and tissue transplantation, the main consequence of such a transmission is infection of the recipient. However, in the case of solid-organ transplantation, and particularly for liver transplantation, donor infections are not only transmitted to the recipient, the donor infection also may affect the donated liver's preservability and subsequent function in the recipient irrespective of the systemic consequences of the infection. In addition, solid organ recipients of infected organs are less able to respond to the infectious agent because of their immunosuppressive treatment. Thus, transmission of infections from organ donor to liver recipient represents serious potential risks that must be weighed against a candidate's mortality risk without the transplant. However, the ever-increasing gap between the number of donors and those waiting for liver grafts makes consideration of every potential donor, regardless of the infection status, essential to minimize waiting list mortality. In this review, we will focus on assessing the risk of transmission of bacterial, fungal, viral, and parasitic infectious agents from cadaveric liver donors to recipients and the effect such a transmission has on liver function, morbidity, and mortality. We will also discuss risk-benefit deliberations for using organs from infected donors for certain types of recipients. These issues are critically important to maximize the use of donated organs but also minimize recipient morbidity and graft dysfunction. (Liver Transpl 2003; 9:451-462.)

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“…12,13 The rate of infection due to a donor organ infection is as low as 0.96% 8 with adequate preoperative antibiotic prophylaxis and aseptic organ retrieval. [14][15][16][17] We believe that adequately treated pretransplant cryptococcosis in a donor will not pose a significant risk of transmission.…”

mentioning

confidence: 99%