The use of corticosteroids to treat ocular inflammation

Visual outcome in a group of dogs with ocular blastomycosis treated with systemic antifungals and systemic corticosteroids

“…anterior uveitis, secondary glaucoma) typically occur as an extension of posterior segment inflammatory processes, and organisms are often not identified in the anterior segment of affected eyes 8 . Because topically applied corticosteroids will not effectively penetrate the posterior segment of the eye, the presence of choroiditis, chorioretinitis or endophthalmitis necessitates systemic medication 14,18 …”

“…In addition to antifungal medication, the use of both topical and systemic corticosteroids has been recommended to treat intraocular inflammation associated with blastomycosis 9,10,13 . This inflammatory response is initiated in the choroid in most cases, 8 and topically administered corticosteroids do not achieve therapeutic concentrations in the posterior segment of the eye 14 . The use of systemic corticosteroids has, however, been considered controversial because of their immune‐suppressive effects and potential exacerbation of systemic disease 15–18 .…”

A clinical comparison of two different prednisolone acetate formulations in patients undergoing cataract surgery

“…These inhibitory effects act on deposition of collagen, edema, capillary dilatation and proliferation, fibrin deposition, leukocyte migration, fibroblast proliferation, and scar formation associated with inflammation [6][7][8][9][10][11] .…”

Plasma and Ocular Prednisolone Disposition after Oral Treatment in Cats

“…Currently, the treatment of feline uveitis of any etiology is based on topical and/or systemic corticosteroid or anti-inflammatory nonsteroidal agents [1, 2]. Despite the fact that the use of potent anti-inflammatory drugs carries the risk of side effects, corticosteroids remain the mainstay of the prevention and treatment of many painful and potentially blinding ocular diseases in different species [3]. Prednisolone is a synthetic adrenocortical steroid used primarily due to its anti-inflammatory activity in several diseases [4].…”