The Use of CT Findings to Predict Extent of Tumor at Primary Surgery for Ovarian Cancer

Glaser, Gretchen; Torres, Michelle; Kim, Bohyun; Aletti, Giovanni; Weaver, Amy L.; Mariani, Andrea; Hartmann, Lynn K.; Cliby, William A.

doi:10.1097/ogx.0b013e3182a4a246

Cited by 3 publications

(14 citation statements)

References 21 publications

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“…Similar results were found in studies done by Glaser G et al, Nelson et al and Meyer et al 17 with a sensitivity and specificity of 72%/65%, 83.3%/83.3% and 80%/100% respectively. 18,33 Enlarged retroperitoneal lymph nodes was detected with an accuracy , sensitivity and specificity of 69.5%,85.7% and 54.8%, respectively in our study which corresponded to results of studies done by G Ferrandina et al where accuracy was 81.9% and specificity was 91.8% and Meyer et al where sensitivity was 60% and specificity100%. 17,30 Diaphragm and base of lung are difficult to differentiate so they were taken together.…”

Section: Discussionsupporting

confidence: 79%

“…It was found that CT scan could detect metastasis to this region with accuracy, sensitivity and specificity of 74.5%, 16.6% and 100% respectively. This is similar to studies done by Glaser G et al, Nelson et al, Bristow et al and Meyer et al 14,17,18,33 The sensitivity and specificity in their studies were 48%/100%, 79.2%/90%, 42%/75% and 54%/87%, respectively. Sensitivity of CT scan to detect sub diaphragm, lung bases and peritoneal deposits was low.…”

Section: Discussionsupporting

confidence: 77%

“…Glaser G et al recently reported on CT and surgical findings correlation in 46 patients. 33 Nelson et al, Bristow et al and Meyer et al conducted studies on 41, 28 and 42 patients respectively.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative study of pre-operative CT scan and per-operative findings in carcinoma ovary

Suchitra¹,

P.²,

Kalla³

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 77%

See 1 more Smart Citation

Comparative study of pre-operative CT scan and per-operative findings in carcinoma ovary

Suchitra¹,

P.²,

Kalla³

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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“…Due to reasonable costs and wide availability, CT is a commonly used imaging method in the preoperative evaluation, staging, and treatment planning of OC. However, it is insufficient to predict the correct stage as accuracy rates are reported between 50% to 92% in some series [8,11,13]. This may be due to the fact that CT evaluative capabilities for each anatomic region are different.…”

Section: Discussionmentioning

confidence: 99%

“…However, none of the methods proved to have sufficient predictive value [5][6][7]. Due to reasonable costs and wide availability, Computed Tomography (CT) is one of the most commonly used imaging methods and CA-125 is the most studied serological marker in OC for this purpose [8][9][10]. Preoperative CT scans can identify the presence of the disease in anatomic regions which are difficult to resect, i.e.…”

Section: Introductionmentioning

confidence: 99%

Computed tomography as a predictor of the extent of the disease and surgical outcomes in ovarian cancer

Cerci

Sakarya²,

Yetimalar³

et al. 2016

Ginekol Pol

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Objectives: The aim of the present study is to determine the predictive value of Computed Tomography (CT), alone or in combination with serum CA-125 levels, for preoperative staging, detection of the extent of the disease, and surgical complications in patients with ovarian carcinoma. Material and methods:One hundred and fourteen patients diagnosed with ovarian carcinoma following an exploratory laparotomy with a preoperative CT scan, performed between January 2007 and June 2013, were enrolled in the study. Preoperative CT and intraoperative surgical findings were compared using 14 parameters and predictions of CT for gastrointestinal, genitourinary, and cardiovascular complications. All radiological features and clinical characteristics were analyzed statistically.Results: CT and surgical findings correlated (sensitivity/ specificity) as follows: uterine and tubal spread (66%/89%), cervical involvement (100%/80%), peritoneal nodulesincreased density-carcinomatosis (57%/93%), omental involvement (68%/95%), retroperitoneal involvement (25%/84%), ascites (85%/87%), perirectal and perivesical fat plan obliteration (43%/94%), liver metastasis (50%/91%), small and large bowel involvement (47%/95%), adnexal mass (94%/70%), and other metastases (47%/86%). Also, CT findings were found to be statistically insignificant for prediction of mesenteric involvement, bladder metastasis, and diaphragmatic involvement. The overall CT sensitivity and specificity at detecting intraoperative findings was 91% and 71%, respectively. We found a statistically significant correlation between intestinal involvement on CT and the necessity of additional surgical procedures. Conclusions:CT is a widely used imaging method in the preoperative evaluation of ovarian cancer. However, its predictive value, sensitivity and specificity differ, depending on the anatomical region.

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Correlation of diaphragm surgical findings with preoperative CT scans in ovarian cancer

Pereira

Magrina²,

Magtibay

et al. 2020

EJGO

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Objective: Correlation of diaphragm surgical findings in ovarian cancer patients with and without diaphragm metastases with pre-operative CT diaphragm findings to assess sensitivity and specificity for diaphragm disease. Material and Methods: A retrospective study of 120 ovarian cancer patients (60 with and 60 without diaphragm metastases at surgery), FIGO Stage IIIC or IV, undergoing cytoreductive surgery at Mayo Clinic, Arizona, between January 2000 and October 2014. All patients had preoperative imaging with CT scan of abdomen and pelvis including the lower lung fields. CTs were not reviewed retrospectively. Results: Among 60 patients with diaphragm metastases, preoperative CTs were positive for diaphragm disease in 17 patients, with a sensitivity rate of 28% (CI 95%: 0.17-0.41). All 60 patients with no diaphragm metastases had negative CTs, with a specificity of 100% (CI 95%: 94.0%-100%). When analyzed by lesion size, CTs were negative in 66.7-80% of patients with diaphragm lesions ranging from 1-15 mm. There was a trend towards increased detection rate with increasing size of lesions, but it did not reach significance (p = 0.529). CT detection rate for single metastatic lesion was 18.2% (6/33) and for multiple lesions it was 25.9% (7/27). There was no difference for CT identification of right, left, or bilateral metastases (p = 0.399). The sensitivity and specificity of CT for pleural effusion was 100% (CI 95%: 72.2%-100%) and 88% (CI 95%: 76.2%-94.4%), respectively. The area under the receiver operating characteristic (ROC) curve was 0.680 (CI 95%: 55.3%-72.2%) for CT detection of diaphragm metastases and 0.957 (CI 95%: 79.9%-95.3%) for pleural effusions. Conclusion: CT has a low sensitivity and a high specificity for the prediction of diaphragm metastases in ovarian cancer. The size, location, and number of diaphragm lesions do not significantly improve CT detection rate.

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The Use of CT Findings to Predict Extent of Tumor at Primary Surgery for Ovarian Cancer

Cited by 3 publications

References 21 publications

Comparative study of pre-operative CT scan and per-operative findings in carcinoma ovary

Comparative study of pre-operative CT scan and per-operative findings in carcinoma ovary

Computed tomography as a predictor of the extent of the disease and surgical outcomes in ovarian cancer

Correlation of diaphragm surgical findings with preoperative CT scans in ovarian cancer

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