The use of D-Dimer assay by enzyme immunoassay and latex agglutination techniques in the diagnosis of deep vein thrombosis

Chapman, Claire; Akhtar, Naim; Campbell, Stuart; Miles, Kenneth A.; O’Connor, John F.; Mitchell, V. E.

doi:10.1111/j.1365-2257.1990.tb01108.x

Cited by 45 publications

(18 citation statements)

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“…It is rarely elevated in healthy people [22] , and its measurement is inexpensive and can be easily and routinely performed in ordinary laboratories.…”

Section: Discussionmentioning

confidence: 99%

High Plasma D-Dimer Indicates Unfavorable Outcome of Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis

et al. 2016

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Background: D-dimer is a fibrin degradation product and a possible marker of thromboembolic events. The aim of this study was to investigate the relationship between D-dimer levels and outcome in acute ischemic stroke (AIS) patients receiving intravenous thrombolysis. Methods: This retrospective study included AIS patients who received intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) and provided plasma D-dimer level within 24 h after stroke onset during 2009 and 2014 at a single medical center. Unfavorable outcome was defined as modified Rankin scale ≥3 at 3 months after stroke. Symptomatic intracerebral hemorrhage (ICH) was defined as a deterioration of at least 4 points on the National Institutes of Health Stroke Scale within 36 h post thrombolysis. Results: Of 347 patients receiving intravenous rt-PA, 159 (mean age 67.6 ± 13.1 year, 59.7% male) fulfilled the inclusion criteria. In univariate analysis, patients with unfavorable outcome (n = 79) had significantly higher levels of D-dimer than those with favorable outcome (median ln D-dimer = 1.4 vs. 0.7 μg/ml, p < 0.001). After adjustment for clinical variables, a higher level of D-dimer remained significantly associated with an unfavorable outcome (OR 1.90, 95% CI 1.27-2.86, p = 0.002) and the occurrence of symptomatic ICH (OR 2.97, 95% CI 1.15-7.70, p = 0.025). Conclusion: The D-dimer level within 24 h after stroke onset can be an early outcome indicator in AIS patients receiving rt-PA therapy.

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“…It is rarely elevated in healthy people [22] , and its measurement is inexpensive and can be easily and routinely performed in ordinary laboratories.…”

Section: Discussionmentioning

confidence: 99%

High Plasma D-Dimer Indicates Unfavorable Outcome of Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis

et al. 2016

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“…Among patients with confirmed PE, higher D‐dimer levels are observed among patients with larger emboli, such as those involving more than 50% of the lung volume, compared to patients with smaller thromboses . Similarly, among patients with DVT, higher D‐dimer levels are observed among patients who have thrombosis extending above the level of the knee compared to patients who have thrombosis confined to their calf (proximal vs distal DVT) . D‐dimer levels fall with increasing duration of VTE symptoms.…”

Section: Introductionmentioning

confidence: 95%

“…D‐dimer levels fall with increasing duration of VTE symptoms. Patients with confirmed DVT who have had symptoms for more than 7 days have lower D‐dimer concentrations compared to patients with DVT and a shorter duration of symptoms . D‐dimer levels also fall rapidly after initiation of treatment (eg heparin, low‐molecular‐weight heparin, vitamin K antagonists).…”

Section: Introductionmentioning

confidence: 99%

Review of D‐dimer testing: Good, Bad, and Ugly

Linkins

Lapner

2017

Int J Lab Hematology

226

166

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D-dimer assays are commonly used in clinical practice to exclude a diagnosis of deep vein thrombosis or pulmonary embolism. More recently, they have been also been used to guide patients with unprovoked venous thromboembolism (VTE) when faced with the decision to continue or stop anticoagulation after initial treatment is complete. D-dimer assays vary widely with respect to the antibody used, method of capture, instrumentation required, and calibration standard. These differences have an important influence on the operating characteristics of the assays. Consequently, the evidence available in the literature for one assay cannot simply be extrapolated to another. In this review, we will outline the general properties of D-dimer assays, discuss the concept of raising the D-dimer threshold used in diagnosis of VTE according to pretest probability and age, and provide clinical perspective on the role of D-dimer testing in the diagnosis and prognosis of VTE.

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“…14-16 Also, thrombus size and location may also affect the sensitivity of D-dimer testing. [17][18][19] Finally, assay interpretation should be a consideration because some qualitative D-dimer assays are observer dependent and, although a D-dimer level of greater than 500 ng/mL is present in the vast majority of patients with acute VTE, cutoff values in quantitative tests are assay dependent.…”

Section: D-dimer Assay In the Diagnosis Of Venous Thromboembolismmentioning

confidence: 98%

Clinical Probability and D-dimer Testing: How Should We Use Them in Clinical Practice?

Hargett

Tapson

2008

Semin Respir Crit Care Med

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Venous thromboembolism (VTE) is extraordinarily common and is a major cause of morbidity and mortality. However, accurate and timely diagnosis of VTE is confounded by its kaleidoscopic presentation. Clinical prediction rules (CPRs) and D-dimer testing have both been increasingly employed to clarify the complex decision making required in such cases. Formal clinical pretest probability now serves as the root of algorithms for the diagnosis of DVT and PE. A low pretest probability of VTE plus a negative D dimer can be combined in a bayesian fashion to effectively exclude the diagnosis of VTE. The evidence for this strategy is strongest in younger outpatients with no associated comorbidities, no prior history of VTE, and a short duration of symptoms.

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The use of D-Dimer assay by enzyme immunoassay and latex agglutination techniques in the diagnosis of deep vein thrombosis

Cited by 45 publications

References 4 publications

High Plasma D-Dimer Indicates Unfavorable Outcome of Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis

High Plasma D-Dimer Indicates Unfavorable Outcome of Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis

Review of D‐dimer testing: Good, Bad, and Ugly

Clinical Probability and D-dimer Testing: How Should We Use Them in Clinical Practice?

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