2015
DOI: 10.1155/2015/684319
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The Use of D‐Optimal Mixture Design in Optimizing Development of Okara Tablet Formulation as a Dietary Supplement

Abstract: The usage of soy is increasing year by year. It increases the problem of financial crisis due to the limited sources of soybeans. Therefore, production of oral tablets containing the nutritious leftover of soymilk production, called okara, as the main ingredient was investigated. The okara tablets were produced using the direct compression method. The percentage of okara, guar gum, microcrystalline cellulose (Avicel PH-101), and maltodextrin influenced tablets' hardness and friability which are analyzed using … Show more

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Cited by 39 publications
(27 citation statements)
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“…There are many types of mixture design of experiments, including simplex-lattice, simplex-centroid, axial design, and D-optimal design (Zen et al, 2015). The D-optimal design was used in this study.…”
Section: Definition Of Mixture Design Of Experimentsmentioning
confidence: 99%
See 1 more Smart Citation
“…There are many types of mixture design of experiments, including simplex-lattice, simplex-centroid, axial design, and D-optimal design (Zen et al, 2015). The D-optimal design was used in this study.…”
Section: Definition Of Mixture Design Of Experimentsmentioning
confidence: 99%
“…The application of mixture design of experiments in the food industry is justified because all foods are mixtures of different ingredients. Mixture design of experiments is an important area of applied statistics and has been used recently in studies on formulation optimization of materials (Javaid et al, 2019), pharmaceuticals (Apeji et al, 2017;Bennani, 2018), and food (Coker et al, 2016;Pattarino, Piepel, & Rinaldi, 2018;Tontul & Topuz, 2017;Tormena, Marcheafave, Rakocevic, Bruns, & Scarminio, 2018;Zen, Gani, Shamsudin, & Masoumi, 2015). In addition to the reduced development time, the experimental mixture design provides reduced product-development costs, reduced raw-material costs, simplified processes, and an increased product shelf life.…”
Section: Introductionmentioning
confidence: 99%
“…In the context of mixture models, that is, when proportions of independent variables add up to unity, optimal designs have become considerably popular, due to the introduction of several new specific algorithms into literature (Zen et al, 2015).…”
Section: Methodsmentioning
confidence: 99%
“…When running a statistical model, it is always advisable to opt for designs with good properties (Zen, Gani, Shamsudin, & Masoumi, 2015). When it comes to problems applied to industry, for instance, rotationality is usually required and, according to Atkinson, Donev and Tobias (2007), that is the main feature of the Central Composite Rotational Design (CCRD).…”
Section: Introductionmentioning
confidence: 99%
“…An insignificant lack of fit is indicated by a low probability value ("Prob > F"), low standard deviation, high adjusted R-squared values, and a low predicted residual sum of squares (PRESS). These explained why these and other statistical parameters used in evaluating and selecting the best-fitted model (Zen et al, 2015;Bakare et al, 2019). From the equation constructed for the best-fitted model, positive coefficient presents a positive contribution toward the response and vice versa.…”
Section: Model Testingmentioning
confidence: 98%