The Use of Dehydrated Human Amniotic Membrane Versus Amniotic/Chorionic Membrane Allografts to Treat Partial Thickness Facial Burns

Abstract

Background: Facial burns have significant physical and psychologic effects on patients. Human dehydrated amniotic membrane represents novel technology, yet its outcome has not been sufficiently studied to guide practice. The objective of our study is to compare the benefits of amniotic membrane (DHAM) to amniotic/chorionic membrane (DHACM) skin substitutes to treat partial thickness facial burns. Methods: Retrospective review of data collected from our institutional burn registry from 2012 to 2016. Demographic characteristics including age, total body surface area (TBSA) burn and injury severity scores were collected and outcome measures were compared between the 2 groups. Paired sample t-test and Chi-squared were used with significance defined as P < 0.05. Results: A total of 77 adult patients with partial thickness facial burns who received DHAM and DHACM skin substitutes were included in the analysis. The mean age for the DHAM group was 39.8 compared to 41.4 for the DHACM. Mean TBSA was similar, with 10.9% in the DHAM group compared to 8.3% in the DHACM. Patients receiving DHAM had higher requirement for skin substitute surgical reapplications as compared to the DHACM group (23.7% versus 5.1%, P ≤ 0.05). Remaining morbidities remained low and not significantly different between patients receiving DHAM and DHACM substitutes (P > 0.05). Conclusion: The DHAM and DHACM skin substitutes are valid and safe alternatives in the treatment of adult partial thickness facial burns.

Comparative evaluation of the efficacy of wound healing with and without dehydrated human amniotic/chorionic membrane in alveoloplasty: a pilot study

“…According to Zhou et al 20 , the amniotic membrane also possesses osteoblastic properties that encourage new bone formation. Similar effects were observed in our previous study when dHACM was used as a graft material for soft tissue healing, and it also contributed to uneventful healing of the alveolar bone underneath [21][22][23] . In this study, a comparison of wound healing efficacy with and without dHACM was performed in alveoloplasty patients.…”

“…They found that the SNOSE strategy was both powerful and affordable. This technique was used in this study to reduce bias 21 .…”

“…This can be attributed to the low level immune response of the amniotic membrane [15][16][17]19 . According to a 2020 study by Puyana et al 21 , amniotic tissue cells expressed microbial peptides like IL-10, tumor necrosis factor (TNF)-α, and interferons, which are known to inhibit inflammation. In this study, a similar effect was seen because dHACM is anti-inflammatory by nature.…”