The Use of Diuretics in the Treatment of Early Wet Lung Syndrome

Acute Hypoproteinemic Fluid Overload: Its Determinants, Distribution, and Treatment with Concentrated Albumin and Diuretics

“…Clinical experience now sug gests that the resulting acute hypoprotéin émie fluid overload may not be innocuous, but variable effects have been recorded fol lowing treatment with diuretics alone [5], concentrated albumin only [24], or both agents in combination [7,23,24]. Recent physiological research has, in principle, con firmed Starling's [26] hypothesis with cer tain refinements [3,8,30], but a controlled experimental study simulating clinical infu sion therapy has, to our knowledge, not For almost three quarters of a century, Starling's [26] concept of the serum colloid osmotic or oncotic pressure as the prime de terminant of the plasma volume went un challenged and was the rationale for the therapeutic use of albumin and plasma pro tein solutions.…”

“…About a decade ago, how ever, Moyer and Butcher [18] and Shires et al [22] postulated that the essential factor is not the oncotic pressure, but the total ex tracellular sodium content. As a result, mas sive volumes of crystalloid solutions -nota- 5 animals each. To procure further data on certain points, a small number of additional experiments were carried out.…”