Without monitoring anthropogenic pressures on the water environment, it is difficult to set realistic river restoration targets in relation to water quality. Therefore a more holistic approach is needed to systematically explore the links between socio-economic drivers and observed water quality-related impacts on river ecosystems. Using the DPSIR (Drivers-Pressures-State of the Environment-Impacts-Responses) framework, this study linked ecological river restoration with the socio-economic sector, with the focus on promoting a pressure-oriented water quality monitoring system. Based on the European Water Framework Directive (WFD) and relevant literature, it was found that most water quality-related indicators employed today are state/impacts-oriented, while very few are pressure-oriented. As a response, we call for more attention to a DPR (Drivers-Pressures-Responses) framework in developing an industrial ecology-based pressure-oriented water quality monitoring system for aiding ecological river restoration planning. This approach is characterized in general by accounting for material-related flows throughout the socio-economic sector in relation to river ecosystem degradation. Then the obtained information would help decision makers take appropriate measures to alleviate various significant human-induced wastes and emissions at their sources. We believe that such a pressure-oriented monitoring system will substantially complement traditional state/impacts-oriented environmental and ecological monitoring and help develop more proactive planning and decision-making processes for specific river restoration projects and general water quality management.