Drones have been employed for multiple uses, such as for military, surveillance, recreational, scientific, and research purposes. Their presence inside civil areas has necessitated the need to regulate their use. Towards this direction, many countries worldwide have issued national legislations, which vary on vehicle categorization according to the size, weight, flight altitude, purpose of use, and restrictions. In this study, we pursued the first comparative analysis of the Organization for Economic Co-operation and Development (OECD) countries’ national legislations, in order to explore the similarities and differences in drone use and recommend improvements and homogenization. Some of the examined countries issued legislation during recent years of drone application, while others amended their existing legislative framework in order to catch up with drone technology evolution. Although from the 35 OECD countries 22 belong to the European Union, we observed much diversity among national legal frameworks. The intensive use of drones has led to severe ethical dilemmas that policy makers will need to address in the near future. We conclude with a proposal regarding the basic legislation for different uses according to the criteria that have been developed so far, followed by limitations and restrictions.