The Use of Electronic Health Records to Study Drug-Induced Hypersensitivity Reactions from 2000 to 2021

Bassir, Fatima; Varghese, Sheril; Wang, Liqin; Chin, Yen Po Harvey; Zhou, Li

doi:10.1016/j.iac.2022.01.004

Cited by 7 publications

(2 citation statements)

References 140 publications

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“…The highest percentage of deaths was observed in the elderly (46.2% ( n = 30)), while in children, it was 3.6 times lower (12.78% ( n = 17)). National pharmacovigilance databases and EHRs are important tools to assess the structure of drugs involved in various allergic reactions including HSRs and to obtain information on the demographic characteristics of patients [ 86 ], although more objective results may be obtained by taking into account data on the actual consumption of the relevant drugs in real clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Drug-Induced Anaphylaxis: National Database Analysis

Butranova,

Zyryanov,

Gorbacheva

et al. 2024

Pharmaceuticals

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(1) Background: National health system databases represent an important source of information about the epidemiology of adverse drug reactions including drug-induced allergy and anaphylaxis. Analysis of such databases may enhance the knowledge of healthcare professionals regarding the problem of drug-induced anaphylaxis. (2) Methods: A retrospective descriptive analysis was carried out of spontaneous reports (SRs) with data on drug-induced anaphylaxis (SRsAs) extracted from the Russian National Pharmacovigilance database (analyzed period 2 April 2019–21 June 2023). The percentage of SRsAs among SRs of drug-induced allergy (SRsDIAs) was calculated, as well as of pediatric, elderly, and fatal SrsAs. Drugs involved in anaphylaxis were assessed among total SRsAs, pediatric, and elderly SRsAs, and among fatal SRsAs. Demographic parameters of patients were assessed. (3) Results: SRsAs were reported in 8.3% of SRsDIAs (2304/27,727), the mean age of patients was 48.2 ± 15.8 years, and females accounted for 53.2% of cases. The main causative groups of drugs were antibacterials (ABs) for systemic use (44.6%), local anesthetics (20.0%), and cyclooxygenase (COX) inhibitors (10.1%). Fatal SRsAs were reported in 9.5% (218/2304) of cases, the mean age of patients was 48.0 ± 16.7 years, and females accounted for 56.4% of cases. Pediatric SRsAs accounted for 3.9% of pediatric SRsDIAs and 5.8% of all SRsAs, with a mean age of 11.8 ± 4.5 years, and females acccounted for 51.9% of cases. Elderly SRsAs accounted for 2% of elderly SRsDIAs and 2.8% of all SRsAs, and the mean age was 73.0 ± 5.3 years, and females accounted for 43.5% of cases. ABs caused 40% of SRsAs in the elderly, 42.9% in children, and 50% of fatal SRsAs. (4) Conclusions: Our study revealed a relatively high proportion of anaphylaxis among SRs of drug-induced allergy. ABs were the most prevalent causative agents, especially in fatal SRsAs.

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Section: Discussionmentioning

confidence: 99%

Drug-Induced Anaphylaxis: National Database Analysis

Butranova,

Zyryanov,

Gorbacheva

et al. 2024

Pharmaceuticals

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“…The highest percentage of deaths was observed in the elderly (46.2% (n -30)), while in children it was 3.6 times less (12.78% (n -17)). National pharmacovigilance databases and EHRs are important tools to assess the structure of drugs involved in various ARs including HSRs and to get information on demographic characteristics of patients [84], though a higher objectivity level of results may be obtained taking into account data on the actual drug consumption in real clinical practice. Conflicts of Interest: "The authors declare no conflict of interest.…”

Section: Discussionmentioning

confidence: 99%

Drug-induced Anaphylaxis: National Database Analysis

Butranova,

Zyryanov,

Gorbacheva

et al. 2023

Preprint

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(1) Background: National health system databases represent one of the most obvious sources of information about epidemiology of adverse drug reactions including drug-induced allergy and anaphylaxis. (2) Methods: Retrospective analysis of data from national database of pharmacovigilance in the Russian Federation (analyzed period 02.04.2019 - 21.06.2023) was performed. The prevalence of anaphylactic reactions (ARs) was determined, the structure of drugs involved was estimated together with patients’ characteristics. (3) Results: ARs were reported in 8.3% of drug-induced allergic reactions (2304/27,727), mean age of patients was 48.2 ± 15.8 years, 53.2% were females. Main causative groups of drugs were antibiotics, ABs (44.62%), local anesthetics, (19.97%), and cyclooxygenase (COX)-inhibitors (10.07%). Fatal ARs was reported in 9.5% (218/2304), mean age 48.0 ± 16.7 years, 56.2% females. Pediatric population accounted for 5.8% (133/2304), mean age 11.8± 4.5 years, 51.9% females. Elderly population accounted for 2.8% (65/2304), mean age 73.0±5.3 years, 43.5% (27/65) females. ABs were the leading causative groups of ARs in the elderly (40%), children (42.86%), and among fatal cases (50%). (4) Conclusions: ARs accounted for 8.3% of all drug-induced allergic reactions, and ABs were the most common causative agents. Females predominated in all groups except elderly patients.

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