The use of elemental fluorine for selective direct fluorinations

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

“…Such mixtures, now commercially available, greatly expanded the scope of fluorination reactions with elemental fluorine. For more comprehensive discussions, the reviews by Purrington et al, Moilet, and Sanford are recommended. Early examples of success include the synthesis of 5-fluorouracil ( 1 ) and related analogues (Scheme ) .…”

Elemental fluorine in organic chemistry (1997–2006)

“…Elemental fluorine has now, it is perhaps fair to say, been accepted by many organofluorine chemists as a viable reagent for synthesis of carbon-fluorine bonds in a range of organic systems. This review will cover published literature concerning the use of elemental fluorine for the synthesis of carbon-fluorine bonds in organic systems over the period 1997-2006, updating our earlier review [8] on this subject in a similar format and complementing other recent discussions in this area [9][10][11]. The fluorination of fullerenes has been reviewed [12,13] and will not be discussed here whilst the chemistry of reagents that are synthesised from fluorine, such as reagents of the N-F class [6,14] and HOF [15], is also beyond the scope of this review.…”

Emerging electrolytes with fluorinated solvents for rechargeable lithium-based batteries

“…Direct fluorination is conducted by attacking the target reactant with electrophilic fluorinating agents. 159,160 The most common fluorination agent for direct fluorination is fluorine gas. 161 Although this reaction is vigorously exothermal, it is easily controlled in a strong acid medium, resulting in an acceptable selectivity and yield (eqn ( 6)).…”