The use of epinephrine infusion for the prevention of spinal hypotension during Caesarean delivery: A randomized controlled dose-finding trial

Hasanin, Ahmed; Amer, Aya Abou; Hassabelnaby, Yasmin; Mostafa, Maha; Abdelnasser, Amr; Amin, Sarah; Elsherbiny, Mona H; Refaat, Sherin

doi:10.1016/j.accpm.2023.101204

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…Norepinephrine is commonly indicated for use in cases of shock and hypotension [16]. Hasanin et al compared norepinephrine to phenylephrine in a double-blinded controlled trial and showed that norepinephrine effectively maintained maternal systolic blood pressure [20]. While the study did show favorable outcomes for reduced post-spinal epidural hypotension, there were adverse effects such as nausea, vomiting, bradycardia, and dry gangrene.…”

Section: Norepinephrinementioning

confidence: 99%

Benefits and Risks of Medications Used in the Management of Hypotension: A Review

Skylynn,

Abel,

Christopher

et al. 2024

Cureus

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This comprehensive literature review addresses the scarcity and limited study of hypotension treatments compared to abundant antihypertensive drugs. Hypotension, categorized as absolute, relative, or orthostatic, has diverse causes. This review explores various treatments, including drugs affecting the sympathetic nervous system, such as midodrine, dihydroergotamine, and ergotamine, which have shown efficacy in managing hypotension. Dopamine agonists/antagonists and other drugs such as ephedrine, norepinephrine, and fludrocortisone are also discussed, each with distinct mechanisms and applications. Additionally, adjunctive agents such as non-steroidal anti-inflammatory agents, caffeine, and monoamine oxidase inhibitors are reviewed for their effects on blood pressure. This review underscores the importance of understanding the efficacy and safety profiles of hypotension treatments to guide healthcare professionals in optimal drug selection and management, emphasizing the need for further research and comparative studies for evidence-based guidelines.

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Section: Norepinephrinementioning

confidence: 99%