The Use of Essential Oils - Alpha and Β-Pinene in the Treatment of Covid-19

Adamski, Andrzej; Adamska, J

doi:10.47829/acmcr.2021.7903

Cited by 3 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reactive exo methylene group in β-pinene makes it able to undergo carbocationic, and to a certain extent radical and coordinative polymerizations. It has to be noted that in addition to poly(β-pinene), this compound is used not only in a range of products, but as a starting material [ 15 , 27 , 28 , 29 , 30 , 31 , 32 ] or therapeutic agent [ 33 , 34 ], and it even has potential in COVID-19 treatment [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Cationic Polymerization of β-Pinene, a Bio-Based, Renewable Olefin, with TiCl4 Catalyst from Cryogenic to Energy-Saving Room Temperature Conditions

Verebélyi

Szabó

Réti

et al. 2023

IJMS

View full text Add to dashboard Cite

Polymers based on renewable monomers are projected to have a significant role in the sustainable economy, even in the near future. Undoubtedly, the cationically polymerizable β-pinene, available in considerable quantities, is one of the most promising bio-based monomers for such purposes. In the course of our systematic investigations related to the catalytic activity of TiCl4 on the cationic polymerization of this natural olefin, it was found that the 2-chloro-2,4,4-trimethylpentane (TMPCl)/TiCl4/N,N,N′,N′-tetramethylethylenediamine (TMEDA) initiating system induced efficient polymerization in dichloromethane (DCM)/hexane (Hx) mixture at both −78 °C and room temperature. At −78 °C, 100% monomer conversion was observed within 40 min, resulting in poly(β-pinene) with relatively high Mn (5500 g/mol). The molecular weight distributions (MWD) were uniformly shifted towards higher molecular weights (MW) in these polymerizations as long as monomer was present in the reaction mixture. However, chain–chain coupling took place after reaching 100% conversion, i.e., under monomer-starved conditions, resulting in considerable molecular weight increase and MWD broadening at −78 °C. At room temperature, the polymerization rate was lower, but chain coupling did not occur. The addition of a second feed of monomer in the polymerization system led to increasing conversion and polymers with higher MWs at both temperatures. 1H NMR spectra of the formed polymers indicated high in-chain double-bond contents. To overcome the polarity decrease by raising the temperature, polymerizations were also carried out in pure DCM at room temperature and at −20 °C. In both cases, rapid polymerization occurred with nearly quantitative yields, leading to poly(β-pinene)s with Mns in the range of 2000 g/mol. Strikingly, polymerization by TiCl4 alone, i.e., without any additive, also occurred with near complete conversion at room temperature within a few minutes, attributed to initiation by adventitious protic impurities. These results convincingly prove that highly efficient carbocationic polymerization of the renewable β-pinene can be accomplished with TiCl4 as catalyst under both cryogenic conditions, applied widely for carbocationic polymerizations, and the environmentally benign, energy-saving room temperature, i.e., without any additive and cooling or heating. These findings enable TiCl4-catalyzed eco-friendly manufacturing of poly(β-pinene)s, which can be utilized in various applications, and in addition, subsequent derivatizations could result in a range of high-added-value products.

show abstract

Section: Introductionmentioning

confidence: 99%

Highly Efficient Cationic Polymerization of β-Pinene, a Bio-Based, Renewable Olefin, with TiCl4 Catalyst from Cryogenic to Energy-Saving Room Temperature Conditions

Verebélyi

Szabó

Réti

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Based on their antimicrobial (Combrinck et al, 2011;Tabassum & Vidyasagar, 2013) and insecticidal (Reyes-Guzman et al, 2012) activities, essential oils have attracted much attention to be used in natural pest and disease control strategies in agricultural and food production (Combrinck et al, 2011). Specifically, there is interest in the development of agents with insect repellent properties (Islam et al, 2017), for the control of disease transmission vectors such as chikungunya and zika (Carpio-Orantes, 2016), insect control in greenhouses (da Camara et al, 2015) and grain stores (Reyes-Guzman et al, 2012), pest control in tree species (Flores-Villegas et al, 2019), control of fungi, bacteria and yeasts causing fruit diseases at postharvest (Rico et al, 2012;Valle-Ortiz et al, 2019) and even for the reduction of viral diseases (Adamski & Adamska, 2021;da Silva et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Debido a su actividad antimicrobiana (Combrinck et al, 2011;Tabassum & Vidyasagar, 2013) e insecticida (Reyes-Guzmán et al, 2012), los aceites esenciales han atraído mucha atención para ser usados en estrategias naturales de control de plagas y enfermedades en la producción agrícola y de alimentos (Combrinck et al, 2011). De forma específica, existe interés por el desarrollo de agentes con propiedades de repelencia a insectos (Islam et al, 2017), para el control de vectores de transmisión de enfermedades como chikunguña y zika (Carpio-Orantes, 2016), control de insectos en invernaderos (da Camara et al, 2015) y almacenes de granos (Reyes-Guzmán et al, 2012), control de plagas en especies arbóreas (Flores-Villegas et al, 2019), control de hongos, bacterias y levaduras causantes de enfermedades en frutos en postcosecha (Rico et al, 2012;Valle-Ortiz et al, 2019) e incluso para la reducción de enfermedades virales (Adamski & Adamska, 2021;da Silva et al, 2020).…”

Section: Introductionunclassified

Composición de aceite esencial de hojas de Schinus molle L. afectada por el tiempo de extracción y escalamiento del proceso

Murrieta-Dionicio,

Medrano-Hernández,

Guerra-Ramírez

et al. 2023

Rev Cha Se Cie For y del Amb

View full text Add to dashboard Cite

Introducción: Schinus molle L. (Anacardiaceae), conocido como pirul en México, es una especie rica en aceite esencial en hojas y frutos.Objetivo: Caracterizar el perfil fitoquímico de aceite esencial obtenido de hojas de S. molle mediante dos sistemas de destilación y distintos tiempos de extracción.Materiales y métodos: Se utilizó un destilador discontinuo Rayleigh de escala intermedia para extraer aceite esencial de hojas de S. molle colectadas en la región central de México. El producto obtenido a distintos tiempos se caracterizó mediante cromatografía de gases y espectrometría de masas (GC-MS). El perfil fitoquímico se comparó con extracto obtenido en aparato Clevenger.Resultados y discusión: El destilador Rayleigh tuvo mayor capacidad de extracción, pero el rendimiento fue 0.6 % menor (P = 0.05) que con el aparato Clevenger a los 120 min. En total se encontraron 37 compuestos, de los cuales 31 estuvieron presentes en el extracto obtenido con destilador Rayleigh, cinco fueron compuestos de baja concentración y uno, catalogado como sesquiterpeno oxigenado, tuvo alta concentración (10.25 %) en el aceite esencial. Con mayor tiempo de extracción, los sesquiterpenos incrementaron y los sesquiterpenos oxigenados disminuyeron. El aceite esencial tuvo presencia mayoritaria de monoterpenos hidrogenados, principalmente de α-felandreno (21.20-28.57 %), limoneno + β-felandreno (19.07-27.78 %), canfeno (3.32-9.93 %), α-pineno (5.74-8.56 %), β-mirceno (2.95-6.91 %) y β-pineno (1.31-3.55 %).Conclusiones: La caracterización del procedimiento de extracción y del perfil químico del aceite esencial de S. molle puede favorecer el aprovechamiento de esta especie.

show abstract

“…The drupe has been used over time as medicine and in foods seasoning as spices. Medicinal effects have been reported due to the presence of terpenes as antiviral (da Silva et al, 2020;Adamski & Adamska, 2021), diuretic, antiseptic, analgesic, antioxidant and anti-inflammatory (Guala et al, 2009;Bigliani et al, 2012;Alonso, 2015;Kim et al, 2015;Gushiken et al, 2022). S molle essential oil is recognized as a substance generally recognized as safe by the Food and Drugs Administration (Schinus molle -ESO, GRAS -182.20).…”

mentioning

confidence: 99%

Characterization of drupe essential oil of Schinus molle L. from Córdoba: Potential uses

Maldonado,

Gusmerini,

Labuckas

et al. 2024

BLACPMA

View full text Add to dashboard Cite

The main components of the essential oil (EO) of Schihus molleL were characterized by Gas Chromatography with Mass Spectrometry (GC-MS). The following components found were: α-pinene (22%), limonene (19%), caryophyllene (11%), β-pinene (8%), γ-gurjunene (6%), 7-Tetracyclo [6.2.1.0(3.8)0(3.9)] undecanol, 4,4,11,11-tetramethyl (5%), β-cadinene (4.11%), ledene oxide (4%), isoledene and β -elemene (3%), and finally δ-cadinene with 2% and others. They are terpene-type compounds in different concentrations. Their potential use in medicine stands out for being anti-inflammatory, anxiolytic, antidepressant, memory loss recovery, kidney and liver problem preventions, antioxidant, immunoprotective and it is also used as anticancer, antimetastatic, among other uses. It also has a potential use as an antifungal, antimicrobial and insecticidal effect. They made it suitable for medical therapies as well as controlling of pests and microorganisms and other applications.

show abstract

The Use of Essential Oils - Alpha and Β-Pinene in the Treatment of Covid-19

Cited by 3 publications

References 22 publications

Highly Efficient Cationic Polymerization of β-Pinene, a Bio-Based, Renewable Olefin, with TiCl4 Catalyst from Cryogenic to Energy-Saving Room Temperature Conditions

Highly Efficient Cationic Polymerization of β-Pinene, a Bio-Based, Renewable Olefin, with TiCl4 Catalyst from Cryogenic to Energy-Saving Room Temperature Conditions

Composición de aceite esencial de hojas de Schinus molle L. afectada por el tiempo de extracción y escalamiento del proceso

Characterization of drupe essential oil of Schinus molle L. from Córdoba: Potential uses

Contact Info

Product

Resources

About