The Use of Extracorporeal Membrane Oxygenation for COVID-19

Parekh, Maansi; Abrams, Darryl; Agerstrand, Cara; Badulak, Jenelle; Dzierba, Amy; Alexander, Peta; Price, Susanna; Fan, Eddy; Mullin, Dana; Díaz, Rodrigo; Hodgson, Carol; Brodie, Daniel

doi:10.1016/j.ccm.2022.11.016

Cited by 5 publications

(3 citation statements)

References 75 publications

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“…Furthermore, evolving clinical guidelines and growing experience among healthcare providers likely contributed to more frequent ECMO deployment as a treatment strategy during this crisis. Recent research has corroborated the increase in ECMO utilization observed in the index study [ 18 , 19 ]. However, there are concerns that centralization of ECMO capacity is lacking in many regions and that the equitable use of ECMO resources remains uneven.…”

Section: Discussionsupporting

confidence: 61%

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Rates, Outcomes, and Resource Burden of Extracorporeal Membrane Oxygenation Use in Hospitalizations in the United States During the Pandemic

Uwumiro,

Otabor,

Okpujie

et al. 2024

Cureus

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Introduction: Extracorporeal membrane oxygenation (ECMO) is a lifesaving medical intervention for patients with severe refractory cardiopulmonary dysfunction. This study aims to characterize hospitalizations and resource use burdens associated with ECMO use during the onset of the pandemic. Methods: We performed a retrospective analysis of ECMO use in United States (US) hospitals between 2019 and 2020, utilizing data from the National Inpatient Sample database. Patient demographics, comorbidities, admission characteristics, inpatient mortality, length of hospital stay (LOS), healthcare costs, and ECMO utilization trends were assessed. Results: Of the 17,520 hospitalizations analyzed, the most common reasons for admission were diseases and disorders of the circulatory system (40.5%) and diseases and disorders of the respiratory system (31.2%). The average patient age was 52.5 years, with a male predominance (64.2%). Hospitalizations were predominantly for White Americans (59.5%), followed by Blacks (16.3%) and Hispanics (14.8%). Nearly 88.2% of cases were at an extremely high risk of mortality without intervention. Inpatient mortality was significantly associated with Hispanic descent, a higher Charlson Comorbidity Index (CCI) score, age >60 years, and a higher All Patients Refined Diagnosis Related Groups (APRDRG) risk of mortality. Hospitalizations involving ECMO had a significantly higher inpatient mortality rate compared to non-ECMO hospitalizations (43.1% vs. 2.1%, p<0.0001). The mean LOS was 26 days for ECMO hospitalizations, with ECMO initiation occurring approximately five days from admission. ECMO-related hospitalizations often involve over 10 unique procedures, resulting in an average healthcare cost of US$967,647 per hospitalization, totaling US$16.7 billion. Comparatively, non-ECMO hospitalizations had shorter LOS and lower mean costs (mean LOS, 4.7 days, and US$52,659, respectively). ECMO utilization increased significantly from 2019 to 2020, reflecting rising demand for this life-saving therapy. Conclusion: Compared to non-ECMO hospitalizations, ECMO patients had higher inpatient mortality, associated with Hispanic descent, higher CCI scores, an age >60 years, and a higher APRDRG risk. ECMO hospitalizations had longer stays (26 days) and higher costs (US$967,647 per case, US$16.7 billion total) compared to pre-pandemic levels. ECMO use increased significantly from 2019 to 2020, reflecting rising demand.

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Section: Discussionsupporting

confidence: 61%

“…Recent research has corroborated the increase in ECMO utilization observed in the index study [18,19]. However, there are concerns that centralization of ECMO capacity is lacking in many regions and that the equitable use of ECMO resources remains uneven.…”

Section: Discussionmentioning

confidence: 70%

Rates, Outcomes, and Resource Burden of Extracorporeal Membrane Oxygenation Use in Hospitalizations in the United States During the Pandemic

Uwumiro,

Otabor,

Okpujie

et al. 2024

Cureus

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“…[1][2][3] Driven in part by the 2009 H1N1 influenza pandemic and the 2019 coronavirus disease (COVID-19) pandemic, ECMO has evolved from a form of resuscitative treatment for patients with a low likelihood of survival to a routine part of high-level critical care, and it has become a life-saving support modality for patients in critical care medicine. [4][5][6][7] According to the Extracorporeal Life Support Organization (ELSO) statistic, 8,9 as of April 18, 2023, a total of 16,803 cases of ECMO were conducted in the year 2022, with a cumulative total of 196,108 cases, and 54% of the patients survived to hospital discharge or transfer. However, ECMO is technically complex, demanding, and challenging to manage during operation; 10,11 Therefore, it often requires specialized teamwork, and ECMO nurses play a significant role during the treatment or management of ECMO patients.…”

Section: Introductionmentioning

confidence: 99%

ICU Nurses’ Perception of Sensitive Indicators of Quality of Care for ECMO Patients in Guizhou Province, China: A Cross-Sectional Study

Cui,

Wang,

et al. 2024

RMHP

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This study aimed to investigate the cognitive evaluation level of ICU nurses in Guizhou Province, China, on the sensitivity indicators of nursing quality for ECMO patients. Patients and Methods: This was a cross-sectional observational study conducted in Guizhou Province, China, from May to July 2023, 259 ICU nurses were surveyed. Objective sampling method was used to select the participants from 10 hospitals in Guizhou Province that carried out ECMO. Data were collected through questionnaire survey. Two researchers checked and recorded Epidata 3.1. SPSS 25.0 was used for statistical analysis of the data, and frequency, mean and component ratio were used for descriptive statistical analysis. The importance rating was used to reflect the degree of nurses' agreement with the indicators. Results:The results of this study showed that 79.1% of the 253 ICU nurses in Guizhou Province, China, had not participated in training and courses related to indicators of quality of care evaluation for ECMO patients. The main way for ICU nurses to acquire knowledge related to indicators of quality of care sensitivity for ECMO patients was departmental training, which accounted for 87.4%. And the other ways, in descending order, were public, the matic lectures or academic conferences, journals and magazines; their evaluation scores of the importance of most of the quality of care sensitivity indicators for ECMO patients was moderate, with the scores ranging from 73 to 150. Among them, the range of importance evaluation scores for each indicator was 4.01 ~ 4.48. Conclusion:The overall cognitive evaluation of ICU nurses in Guizhou Province, China, on most sensitivity indicators of quality of care for ECMO patients was moderate, and there is a general lack of systematic courses and training on the knowledge related to ECMO care quality sensitive indicators.

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