A fiber optic thermometer based on the lifetime of Cr:LiSAF fluorescence, induced by visible light, is reported, for applications in the monitoring of temperature during clinical heat treatment on Benign Prostatic Hyperplasia. As the heat source for such treatment stems from an externally applied Radio Frequency (RF) field (434MHz), unlike the current technology which uses thermocouples as the temperature sensing element, the use of such a fiber optic thermometer, which is immune to RF interference, allows for the continuous monitoring of temperature and hence further enhances patient safety. In addition, the application of an un-pulsed external RF field as the heat source (necessary with the use ofthermocouple-based monitoring), also simplifies the operating of the treatment. A newly developed effective technique for the detection of the fluorescence lifetime for temperature measurement is used, together with the application of a red (670nm) diode laser as the excitation source, to produce a compact and inexpensive device for this lifetime-based instrument. The temperature dependence of Cr:LiSAF fluorescence lifetime is discussed, with an empirical formula, which can be used for the calibration ofthe thermometer being presented to describe such dependence. The thermometer covers the temperature region 10-100°C, with response time less than one second and a satisfactory accuracy under laboratory test conditions is achieved.