The use of fractional exhaled nitric oxide in investigation of work‐related cough in a hairdresser

Pala, Gianni; Pignatti, Patrizia; Moscato, Gianna

doi:10.1002/ajim.20948

Cited by 21 publications

(18 citation statements)

References 12 publications

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“…FeNO is an indirect marker of eosinophilic airway inflammation that may be increased in asthma [Pala et al, 2011; Quirce et al, 2012]. In patients with refractory asthma, low FeNO levels have been found to be associated with the presence of neutrophils in the sputum [Tseliou et al, 2010].…”

Section: Discussionmentioning

confidence: 99%

Styrene‐associated health outcomes at a windblade manufacturing plant

McCague

Cox‐Ganser

Harney

et al. 2015

American J Industrial Med

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Background Health risks of using styrene to manufacture windblades for the green energy sector are unknown. Methods Using data collected from 355 (73%) current windblade workers and regression analysis, we investigated associations between health outcomes and styrene exposure estimates derived from urinary styrene metabolites. Results The median current styrene exposure was 53.6 mg/g creatinine (interquartile range: 19.5–94.4). Color blindness in men and women (standardized morbidity ratios 2.3 and 16.6, respectively) was not associated with exposure estimates, but was the type previously reported with styrene. Visual contrast sensitivity decreased and chest tightness increased (odds ratio 2.9) with increasing current exposure. Decreases in spirometric parameters and FeNO, and increases in the odds of wheeze and asthma-like symptoms (odds ratios 1.3 and 1.2, respectively) occurred with increasing cumulative exposure. Conclusions Despite styrene exposures below the recommended 400 mg/g creatinine, visual and respiratory effects indicate the need for additional preventative measures in this industry.

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Section: Discussionmentioning

confidence: 99%

Styrene‐associated health outcomes at a windblade manufacturing plant

McCague

Cox‐Ganser

Harney

et al. 2015

American J Industrial Med

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“…Assessment of changes in exhaled nitric oxide fraction (FeNO) level during SIC may be useful in subjects who fail to provide suitable sputum samples [85,86]. There have been conflicting data on the changes in FeNO after SIC with occupational agents [87][88][89][90][91][92][93][94][95].…”

Section: Exhaled Nitric Oxidementioning

confidence: 99%

Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement

et al. 2014

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This consensus statement provides practical recommendations for specific inhalation challenge (SIC) in the diagnosis of occupational asthma. They are derived from a systematic literature search, a census of active European centres, a Delphi conference and expert consensus. This article details each step of a SIC, including safety requirements, techniques for delivering agents, and methods for assessing and interpreting bronchial responses. The limitations of the procedure are also discussed.Testing should only be carried out in hospitals where physicians and healthcare professionals have appropriate expertise. Tests should always include a control challenge, a gradual increase of exposure to the suspected agent, and close monitoring of the patient during the challenge and for at least 6 h afterwards. In expert centres, excessive reactions provoked by SIC are rare.A positive response is defined by a fall in forced expiratory volume in 1 s o15% from baseline. Equivocal reactions can sometimes be clarified by finding changes in nonspecific bronchial responsiveness, sputum eosinophils or exhaled nitric oxide. The sensitivity and specificity of SIC are high but not easily quantified, as the method is usually used as the reference standard for the diagnosis of occupational asthma. @ERSpublications ERS Task Force: a statement on specific inhalation challenges in the diagnosis of occupational asthma

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“…FeNO evaluations in subjects with work related cough could be useful for both the occupational diagnosis (26) and management of the disease in the workplace. More data are needed on the utility of FeNO evaluation as a marker of corticosteroid responsiveness also in occupational cough.…”

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confidence: 99%