The use of GD DTPA as a perfusion agent and marker of blood-brain barrier disruption

Runge, Val M.; Clanton, Jeffrey A.; Price, Angie; Wehr, Chris J.; Herzer, William A.; Partain, C. Leon; James, A. Everette

doi:10.1016/0730-725x(85)90008-6

Cited by 81 publications

(30 citation statements)

References 13 publications

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“…However, contrast enhancement is not always accurate in predicting the grade of a tumor, and all high-grade tumors do not enhance. 27 Moreover, it has been shown previously that metabolic abnormality extends beyond the contrast-enhanced areas in brain tumors. 12 Perfusion-weighted images (ASL, DSC, or dynamic contrast enhanced), reflect true alterations in the physiology of a tumor.…”

Section: Discussionmentioning

confidence: 99%

Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas

Chawla¹,

Wang²,

Wolf³

et al. 2007

American Journal of Neuroradiology

100

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Section: Discussionmentioning

confidence: 99%

Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas

Chawla¹,

Wang²,

Wolf³

et al. 2007

American Journal of Neuroradiology

100

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“…[25][26][27] Conventional MR imaging provides important anatomic information; however, it is insufficient in determining the grade of the tumors preoperatively. 17 Contrast enhancement on MR imaging depicts areas of breakdown of blood-brain barrier, 28 which is often associated with higher tumor grade; however, contrast enhancement is not always accurate in predicting the tumor grade. 8,[29][30][31][32] Even in the high-grade gliomas with pathologic contrast enhancement, the enhancement may not reflect the areas of neovascularity and angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Role of Perfusion CT in Glioma Grading and Comparison with Conventional MR Imaging Features

Ellika

Jain²,

Patel³

et al. 2007

American Journal of Neuroradiology

119

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“…Conventional MRI provides a sensitive measure of tissue structure and water content and, through the use of intravenous contrast agents, can also measure blood-brain barrier (BBB) permeability (Runge et al, 1985) and cerebral perfusion (Rosen et al, 1990). Diffusionweighted MRI (DWI) acutely detects ischemic changes believed to be associated with disrupted cellular homeostasis (Mintorovitch et al, 1991;Minematsu et al, 1992b;van Bruggen et al, 1992).…”

Section: Abstract: Interleukin-1␤; Magnetic Resonance; Diffusion; Cementioning

confidence: 99%

Interleukin-1β-Induced Changes in Blood–Brain Barrier Permeability, Apparent Diffusion Coefficient, and Cerebral Blood Volume in the Rat Brain: A Magnetic Resonance Study

et al. 2000

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The cytokine interleukin-1␤ (IL-1␤) is implicated in a broad spectrum of CNS pathologies, in which it is thought to exacerbate neuronal loss. Here, the effects of injecting recombinant rat IL-1␤ into the striatum of 3-week-old rats were followed noninvasively from 2 to 123 hr using magnetic resonance imaging and spectroscopy. Four hours after injection of IL-1␤ (1 ng in 1 l), cerebral blood volume was significantly increased, the blood-brain barrier (BBB) became permeable to intravenously administered contrast agent between 4.5 and 5 hr, and the apparent diffusion coefficient (ADC) of brain water fell by 6 hr (5.42 Ϯ 0.35 ϫ 10 Ϫ 4 mm 2 /sec treated, 7.35 Ϯ 0.77 ϫ 10 Ϫ 4 mm 2 /sec control; p Ͻ 0.001). At 24 hr the BBB was again intact, but the ADC, although partially recovered, remained depressed at both 24 and 123 hr ( p Ͻ 0.03). Depleting the animals of neutrophils before IL-1␤ injection prevented the BBB permeability at all time points, but the ADC was still depressed at 6 hr (6.64 Ϯ 0.34 ϫ 10 Ϫ 4 mm 2 /sec treated, 7.49 Ϯ 0.38 ϫ 10 Ϫ 4 mm 2 /sec control; p Ͻ 0.005). No changes were seen in brain metabolites using proton spectroscopy at 6 hr after IL-1␤.Intraparenchymal injection of IL-1␤ caused a neutrophildependent transient increase in BBB permeability. The presence of neutrophils within the brain parenchyma significantly contributed to the IL-1␤-induced changes in cerebral blood volume and the ADC of brain water. However, IL-1␤ apparently had a direct effect on the resident cell populations, which persisted well after all recruited leukocytes had disappeared. Thus the action of IL-1␤ alone can give rise to magnetic resonance imaging-visible changes that are normally attributed to alterations to cellular homeostasis.

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The use of GD DTPA as a perfusion agent and marker of blood-brain barrier disruption

Cited by 81 publications

References 13 publications

Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas

Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas

Role of Perfusion CT in Glioma Grading and Comparison with Conventional MR Imaging Features

Interleukin-1β-Induced Changes in Blood–Brain Barrier Permeability, Apparent Diffusion Coefficient, and Cerebral Blood Volume in the Rat Brain: A Magnetic Resonance Study

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