The Use of Glucan as Immunostimulant in the Treatment of Paracoccidioidomycosis

Da, Meira; Pc, Pereira; Marcondes-Machado, Jussara; Rp, Mendes; Barraviera, Benedito; J, Pellegrino Júnior; Mt, Rezkallah-Iwasso; Mt, Peracoli; Lm, Castilho; Thomazini, I; Cl, Da Silva; Nt, Foss; Pr, Curi

doi:10.4269/ajtmh.1996.55.496

Cited by 45 publications

(29 citation statements)

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“…O sistema imune do hospedeiro é estimulado pela β-glucana em resposta à formação de tumores (KOGAN et al, 2002;KHALIKOVA et al, 2005) e contra infecções (TZIANABOS, 2000). Existem diversos relatos que comprovam o efeito imunomodulatório em infecções de origem bacteriana CISNEROS, 1996;LIANG et al, 1998), viral (REYNOLDS et al, 1980JUNG et al, 2004), fúngica (MEIRA et al, 1996) e parasitária (HOLBROOK; COOK; PARKER, 1981).…”

Section: Atividade Imunomodulatória Da β-Glucanaunclassified

Beta-glucana de Saccharomyces cerevisiae: constituição, bioatividade e obtenção

Magnani

Castro-Gómez

2008

Sem. Ci. Agr.

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Resumoβ-glucanas são polissacarídeos constituintes estruturais da parede celular de leveduras, fungos e alguns cereais, que se diferenciam pelo tipo de ligação presente entre as unidades de glicose. Uma importante fonte destes polissacarídeos é a parede celular de Saccharomyces cerevisiae, uma levedura amplamente empregada em processos industriais de fermentação. A β-glucana é considerada um modificador da resposta biológica devido ao seu potencial imunomodulador, pois ao ser reconhecida por receptores celulares específicos tem habilidade de realçar a resposta imune do hospedeiro. Outros efeitos benéficos como anticarcinogênico, antimutagênico, hipocolesterolêmico e hipoglicêmico também têm sido relacionados à β-glucana Esta revisão de literatura teve por objetivo agregar conhecimentos científicos sobre a constituição e bioatividade da β-glucana, incluindo seu reconhecimento pelo sistema imune, bem como, a obtenção a partir da parede celular de S. cerevisiae. Palavras-chave: β-glucana, Saccharomyces cerevisiae, bioatividade, imunomodulador, sistema imune Abstract β-glucans are polysaccharides that constitute the structure of the cell wall of yeast, fungi and some cereals, which differs each other by the linkages between glucose units. An important source of these polymers is the Saccharomyces cerevisiae cell wall, which is a yeast widely used in industrial processes of fermentation. The β-glucan is considered to be a modifier of biological response due to its immunomodulator potential. When it is recognized by specific cellular receptors, have the ability to enhance the host's immune response. Other beneficial effects such as anticarcinogenic, antimutagenic, hypocholesterolemic and blood sugar reduction have also been related to the β-glucan. The aim of this literature review was expand scientific knowledge about the constitution and bioactivity of β-glucan, including its recognition by the immune system, as well as its obtaining from S. cerevisiae cell wall.

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Section: Atividade Imunomodulatória Da β-Glucanaunclassified

Beta-glucana de Saccharomyces cerevisiae: constituição, bioatividade e obtenção

Magnani

Castro-Gómez

2008

Sem. Ci. Agr.

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“…[8][9][10][11][12][13][14][15][16][17][18][19][20] Pe li zon et al re por ted that be ta-glu can ad mi nis tra ti on en han ced fun gi ci dal ac ti vity on Para coc ci di o i des bra si li en sis in the mi ce mo del by pri ming sple en cells for high pro duc ti on of IL-12 and TNF-alp ha as well as in cre a sing NK cell ac tivity. 19 In a rat mo del of sep sis, the pro tec ti ve ef fect of be ta-glu can aga inst oxi da ti ve or gan in jury by dep res sing li pid pe ro xi da ti on was de mons tra ted.…”

Section: Methodsmentioning

confidence: 99%

“…[15][16][17] Stu di es, ho we ver, abo ut the pos sib le pro tec ti ve ef fect on fun gal in fec ti ons are li mi ted. [18][19][20] We de sig ned this study to in ves ti ga te the possib le pro tec ti ve ef fects of be ta-glu can aga inst Asper gil lus fu mi ga tus in fec ti on using con ven ti o nal and se ro lo gi cal ap pro ac hes in an im mu no sup pressed rat mo del.…”

mentioning

confidence: 99%

Protective Effect of Beta Glucan on Pulmonary Aspergillosis Model in Neutropenic Rats

Hızel¹,

Kalkancı²,

Çağlar³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Pul mo nary as per gil lo sis is a se ri o us op por tu nis tic in fec ti on which might be fa tal in im mu no com pro mi sed pa ti ents. Im mu nity aga inst as per gil lo sis re qu i res the co or di na ted acti on of com po nents of the in na te and adap ti ve im mu ne systems. Be ta-glu can is one of the im muno mo du la tory agents which got much at ten ti on in re cent ye ars. It was used as a pre ven ti ve agent for the de ve lop ment of in fec ti ons. Ho we ver, in for ma ti on abo ut its the pos sib le pro tec ti ve ef fect on fun gal in fec ti ons are li mi ted. The aim of this study aimed to in ves ti ga te the pos sib le pro tec ti ve effects of be ta-glu can aga inst As per gil lus fu mi ga tus in fec ti on. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : We eva lu a ted oral be ta glu can ad mi nis tra ti on for its abi lity to en han ce re sis tan ce of the rats to ex pe ri men tally indu ced pul mo nary as per gil lo sis. Fifty-eight rats we re di vi ded in to thre e gro ups: Thirty fi ve rats were im mu no sup pres sed and in fec ted with As per gil lus fu mi ga tus (in fec ted gro up); 15 we re im mu no sup pres sed, in fec ted and tre a ted with oral be ta-glu can (be ta-glu can gro up); and eight were he althy con trols. Rats we re sac ri fi ced on the tenth day of the ex pe ri ment and tis su e spe ci mens we re cul tu red. Chi tin, ga lac to man nan an ti gen and glu can le vels we re detected. R Re e s su ul lt ts s: : Be ta-glucan en han ced the re sis tan ce aga inst As per gil lus in fec ti on. The sur vi val ra tes we re 62.9 % and 93.4% in the in fec ted and be ta-glu can gro ups, res pec ti vely (p< 0.05). Be ta glu can al so li mi ted the fun gal bur den. C Co on nc c l lu u s si i o on n: : Our re sults sug ges ted that As per gil lus in va si on did not de ve lop in be ta-glu can gro up in spi te of the oc cu ren ce of fun gal co lo ni za ti on in ne ut ro pe nic rats. Be ta-glu can was ab le to im pro ve the re sis tan ce aga inst A. fu mi ga tus in fec ti on. K Ke ey y W Wo or rd ds s: : As per gil lo sis; be ta-glu cans; cytop ro tec ti on; im mu no sup pres si on Ö ÖZ ZE ET T A Am ma aç ç: : Pul mo ner as per gil loz im mün yet mez lik li has ta lar da ölüm cül ola bi len cid di bir fır sat -çı en fek si yon dur. As per jil lo zi se kar şı ba ğı şık lık do ğuş tan ge len ve adap tif im mün sis tem le rin bi leşen le ri nin bir lik te ha re ket et me si ni ge rek ti rir. Be ta-glu kan son yıl lar da çok dik kat çe ken im mü no mo dü la tör ajan lar dan bi ri dir. En fek si yon ge li şi min de ko ru yu cu ajan ola rak kul la nıl mış tır. Fa kat man tar en fek si yon la rın da ki ola sı ko ru yu cu et ki si hak kın da ki bil gi sı nır lı dır. Bu ça lış ma nın ama cı be ta-glu ka nın As per gil lus fu mi ga tus en fek si yo nu na kar şı ola sı ko ru yu cu et ki le ri ni araş tır -mak tı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Oral be ta-glu kan ve ril me si nin fa re le rin de ney sel ola ...

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“…Since then, several more cases were diagnosed, but only three of them, fatal cases, have been published [1,3,7]. Until December 2004 a total of 79 cases have been diagnosed in patients coming from the states of Piauí (66), Ceará (6), Maranhão (5) and Bahia (2).…”

Section: Serviço De Micologia Instituto De Pesquisas Clínicas Evandrmentioning

confidence: 99%

“…In this study we compared JF (n=10) and AF (n=15) patients with PI individuals (n=15) in relation to the kinetics of mRNA expression of Th1 and Th2 cytokines, IFN-γ-induced chemokines CXCL9 (Mig) and CXCL10 (IP-10) and determined the cells responsible for their production. The time kinetics (0,3,6, 12, 24 and 48 hours after PHA stimulus) of IFN-γ, TNF-α, IL-4, IL-10, CXCL9 and CXCL10 mRNA expression was analyzed by a semi-quantitative RT-PCR (normalized by b-actin mRNA). Protein expression was assessed by flow-cytometry.…”

Section: Departamento De Patologia Clínica -Faculdade De Ciências Médmentioning

confidence: 99%

Clinical immunology

2005

Rev. Inst. Med. trop. S. Paulo

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Paracoccidioides brasiliensis, a thermo-dimorphic fungus, is the etiologic agent of paracoccidioidomycosis (PCM). The recidive is the greatest obstacle of this disease, because the yeast usually returns after the long treatment period. In the present work, we have investigated the cellular immune response of cells from peripheral blood drawn from patients with different duration of PCM. The classification of patients ranged from no treated to those with longstanding disease over 5 years. No stimulated as well as cells stimulated with phytohemaglutinin or two different antigen preparations, secreted (MEXO) or somatic (PbAg) of P. brasiliensis, were characterized. We found that cells from patients with disease proliferate considerably upon stimulation with the antigen preparations and that cells from patients with disease of long duration does not proliferate that vigorously as from patients with more recent diagnosis. Both interferon (IFN)-γ and interleukin (IL)-4 appear to be increased in patients, but IFN-γ tended to increase upon treatment while IL-4-secretion decreased. With respect to CD28 and CD86, we found that the subset of CD28 positive CD8 cells is decreased in all stages of the disease as compared to control individuals. A subset of CD86 positive CD19 cells appeared to be considerably increased compared to the controls. Indeed, our results demonstrated that the treatment of PCM patients promoted a regulation of IFN-γ, IL-4 levels and CD28, CD86 expression bringing new insight to the cellular immune response in PCM. In order to balance the host-parasite interaction in its favor, P. brasiliensis must take advantage of a number of mechanisms to dampen hosts´ immune responses at several checkpoints, either to allow its dissemination from the initial site of infection or to allow its safe persistence within the host for years or decades. In our pursue to dissect such mechanisms we have shown, on one hand, that stimulation with the main P. brasiliensis antigen (gp43) of PBMC from patients with active PCM lead to decreased IL-12, IL-2 and IFN-g secretion but high IL-10 levels. In parallel, gp43 induced low (or not at all) IL-12R β2 expression in patients' T-cells, but high expression in controls; C. albicans antigen (CMA) did it quite comparably in both groups. MODULATION OF THE ANTIGEN-SPECIFIC RESPONSES IN PARACOCCIDIOIDOMYCOSIS PATIENTS: THE ROLE OF CYTOKINES AND COSTIMULATORY MOLECULESGilThese findings suggest a specific imbalance in the IL-12/INF-γ/IL-10 regulation. In this regard, it has recently been shown that cytokines modulate the expression and activity of the family of "signal transducers and activators of transcription" (STATs): e.g., IFN-γ enhances its functionality. We will show that this also holds true in PCM patients. We will show that there is a severe impairment of STAT1 expression in T cells from patients as compared to controls. This likely may impact the anti-P. brasiliensis macrophage activities and the host´s ability in mounting Th-1 type responses.On the other hand, we have shown tha...

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The Use of Glucan as Immunostimulant in the Treatment of Paracoccidioidomycosis

Cited by 45 publications

References 0 publications

Beta-glucana de Saccharomyces cerevisiae: constituição, bioatividade e obtenção

Beta-glucana de Saccharomyces cerevisiae: constituição, bioatividade e obtenção

Protective Effect of Beta Glucan on Pulmonary Aspergillosis Model in Neutropenic Rats

Clinical immunology

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