The Use of Glycolic Acid as a Peeling Agent

Murad, Howard; Shamban, Ava; Premo, Paul Scott

doi:10.1016/s0733-8635(18)30082-2

Cited by 71 publications

(60 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mechanism of action of cr acids on epidermal and dermal compartments needs clarification. Alpha-glycolic acid has been demonstrated effective as a chemical peeling agent (16,17), induces turnover of the stratum corneum (18) and causes a significant increase in glucosaminoglycan and collagen content of epidermis (19). Antioxidant activity ofc~-glycolic acid was also put forward (20).…”

Section: Mal96@mboxunipaitmentioning

confidence: 99%

Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

Morreale

Livrea

1997

IUBMB Life

View full text Add to dashboard Cite

Summary. Considerable interest has been raised concerning the use of natural compounds in preventing skin aging and photoaging In the idea that the combined action of agents increasing epiderlnal turnover with antioxidants could be ach,antageous in cosmetic and therapeuthic treatments, we first investigated if ~z-glycolic acid affected or prevented the antioxidant activity of vitanffn E and of melatonin, two compounds found beneficial as topical photoprotectant. Assays were carried out m vitro either in a biomimetic liposomal system, or in human skin homogenates. Lipid peroxidation was monitored spectrophotometrically by the time course of lipid hydroperoxide production in liposomes and by formation of TBA reactive substances (TBARS) in skin homogenates. Glycolic acid. at 25 ~tM to 1 raM, showed a mild, concentration-dependent antioxidant effect in liposomes, as evalnated by a slight decrease of the peroxidation rate, while, at I mM, reduced TBARS production in skin homogenates by 14 %. Combinations of either vitamin E or melatonin with giycolic acid, in a 1:5 to 1:200 molar ratio, resulted in a clear synergistic protection of liposomes, more evident for the combination of glycolic acid with vitamin E An amount of ~'nergism up to 250% and up to 80% was evahmted with vitamin E and melatonin, respectively. Consumption rate ofvitanffn E during peroxidation of liposomes, in the absence or in the presence of glycolic acid, suggests that regeneration of vitamin E 1nay in part explain the observed synergism. Synergistic antioxidant activity between vitamin E and giycolic acid was also observed in skin homogenates, whereas the effect of glycolic acid on the antioxidunt activity of melatonin appeared additive. However, the combination of these three compounds inhibited TBARS production almost completely.Our data provide evidence that glycolic acid can strongly potentiate the antioxidant action of melatonin and vitamin E. Tiffs may suggest the advantage of combining ~-glycolic acid with these antioxidants in skin designed preparations, both to improve penetration and availability of antioxidants to epidermal layers and to enhance their protective potential.

show abstract

Section: Mal96@mboxunipaitmentioning

confidence: 99%

Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

Morreale

Livrea

1997

IUBMB Life

View full text Add to dashboard Cite

show abstract

“…It is an alphahydroxy acid (AHA) naturally occurring in sugarcane [300,301]. The exact mechanism of glycolic acid is unknown, but it has been suggested that it decreases corneocyte cohesion at the lower levels of the stratum corneum, perhaps by interfering with the formation of ionic bonds [301]. It is usually used as a 50 or 70 % solution and, unlike some other chemical peeling agents, is often used as a series of peels separated by 1-4 weeks [301].…”

Section: Glycolic Acidmentioning

confidence: 99%

“…The exact mechanism of glycolic acid is unknown, but it has been suggested that it decreases corneocyte cohesion at the lower levels of the stratum corneum, perhaps by interfering with the formation of ionic bonds [301]. It is usually used as a 50 or 70 % solution and, unlike some other chemical peeling agents, is often used as a series of peels separated by 1-4 weeks [301]. Glycolic acid can be used to treat ichthyosis, actinic and seborrheic keratoses, lentigines, melasma, postinflammatory hyperpigmentation, superficial rhytides, acne, warts, and for overall cutaneous improvement [301].…”

Section: Glycolic Acidmentioning

confidence: 99%

Damaged Skin

Burgher¹,

Mathieu²,

Blomet

et al. 2014

Chemical Skin Injury

View full text Add to dashboard Cite

“…Among the AHAs, glycolic acid (GA) was the most promising, and several studies have demonstrated an improvement of hyperpigmented lesions due to photodamage and photo-ageing [23,[33][34][35][36][37][38]. Although GA and HQ, alone or combined to other drugs, have been used in the treatment of wrinkles, photo-ageing and melasma [39][40][41][42], recently a cream combining GA 10% and HQ 2% has proved its efficacy [43].…”

Section: ·-Hydroxy Acidsmentioning

confidence: 99%

RALGA (Diacnéal<sup>®</sup>), a Retinaldehyde and Glycolic Acid Association and Postinflammatory Hyperpigmentation in Acne – A Review

Katsambas¹

2005

Dermatology

View full text Add to dashboard Cite

Acne vulgaris affects 3 out of 4 adolescents and usually vanishes at the end of puberty with either no sequelae or mild to moderate sequelae, such as postinflammatory hyperpigmenation (PIH), which may result in psychological and emotional damages. The poor tolerability of the actual treatments (secondary inflammation) is a hindrance to therapy. Retinaldehyde (RAL), a precursor of retinoic acid, has shown depigmenting activity. Glycolic acid (GA) decreases the excess of pigment by a wounding and re-epithelization process. Thus, a synergistic effect was expected from the combination of RAL 0.1% and GA 6% RALGA (Diacnéal^®) in the treatment of acne vulgaris and PIH. Efficacy results of preclinical and clinical trials tend to confirm the expectations for both acne and PIH treatment. A good tolerability was observed. In conclusion, the cosmetic cream Diacnéal is a well-tolerated treatment for the prevention and healing of PIH in acne patients.

show abstract

The Use of Glycolic Acid as a Peeling Agent

Cited by 71 publications

References 18 publications

Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

Damaged Skin

RALGA (Diacnéal<sup>®</sup>), a Retinaldehyde and Glycolic Acid Association and Postinflammatory Hyperpigmentation in Acne – A Review

Contact Info

Product

Resources

About